Detalhe da pesquisa
1.
Disease-associated mutations impacting BC-loop flexibility trigger long-range transthyretin tetramer destabilization and aggregation.
J Biol Chem
; 297(3): 101039, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34343569
2.
DNA activates the Nse2/Mms21 SUMO E3 ligase in the Smc5/6 complex.
EMBO J
; 37(12)2018 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29769404
3.
Molecular mechanisms in SUMO conjugation.
Biochem Soc Trans
; 48(1): 123-135, 2020 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31872228
4.
Combining Structural Aggregation Propensity and Stability Predictions To Redesign Protein Solubility.
Mol Pharm
; 15(9): 3846-3859, 2018 09 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30036481
5.
The importance of a gatekeeper residue on the aggregation of transthyretin: implications for transthyretin-related amyloidoses.
J Biol Chem
; 289(41): 28324-37, 2014 Oct 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-25086037
6.
Broad-spectrum ubiquitin/ubiquitin-like deconjugation activity of the rhizobial effector NopD from Bradyrhizobium (sp. XS1150).
Commun Biol
; 7(1): 644, 2024 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38802699
7.
Using Intrinsic Fluorescence to Measure Protein Stability Upon Thermal and Chemical Denaturation.
Methods Mol Biol
; 2581: 229-241, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36413321
8.
PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties.
Eur J Med Chem
; 261: 115837, 2023 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37837673
9.
Structural basis for the SUMO protease activity of the atypical ubiquitin-specific protease USPL1.
Nat Commun
; 13(1): 1819, 2022 04 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35383180
10.
Development of a Highly Potent Transthyretin Amyloidogenesis Inhibitor: Design, Synthesis, and Evaluation.
J Med Chem
; 65(21): 14673-14691, 2022 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36306808
11.
Characterization of the unfolding process of the tetrameric and dimeric forms of Cratylia mollis seed lectin (CRAMOLL 1): effects of natural fragmentation on protein stability.
Biochemistry
; 50(34): 7330-40, 2011 Aug 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-21790141
12.
Heterologous expression and purification of a biologically active legume lectin from Cratylia mollis seeds (CRAMOLL 1).
Biochim Biophys Acta
; 1804(9): 1917-24, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20538076
13.
Structural basis for the E3 ligase activity enhancement of yeast Nse2 by SUMO-interacting motifs.
Nat Commun
; 12(1): 7013, 2021 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34853311
14.
Tolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis.
FEBS J
; 288(1): 310-324, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32324953
15.
Structural Mechanism for the Temperature-Dependent Activation of the Hyperthermophilic Pf2001 Esterase.
Structure
; 26(2): 199-208.e3, 2018 02 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29307486
16.
Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation.
Sci Rep
; 7: 44709, 2017 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28338000
17.
pCramoll and rCramoll lectins induce cell death in human prostate adenocarcinoma (PC-3) cells by impairment of mitochondrial homeostasis.
Toxicol In Vitro
; 43: 40-46, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28552641
18.
Encapsulation into Stealth Liposomes Enhances the Antitumor Action of Recombinant Cratylia mollis Lectin Expressed in Escherichia coli.
Front Microbiol
; 7: 1355, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27695439
19.
Structure-based analysis of A19D, a variant of transthyretin involved in familial amyloid cardiomyopathy.
PLoS One
; 8(12): e82484, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24358189