Surface tension anomaly observed for chemically-modified Janus particles at the air/water interface.

The behavior of Janus particles fabricated from core silica particles decorated with gold nanoparticles on one hemisphere is studied at the air/water interface. An unexpected reduction in the effective surface tension is observed in the presence of these chemically-modified Janus particles. Experiments on the interfacial behavior of a variety of control particles, including the physically-modified Janus particles made from the same core silica particles coated with a thin gold layer, do not exhibit significant surface tension effects. We hypothesize that the chemical modification of particles in form of a Janus structure is needed to alter the surface tension and attribute the surfactant-like behavior of these particles to the presence of immersion forces.

Efficacy and Molecular Effects of a Reduced Graphene Oxide/Fe3O4 Nanocomposite in Photothermal Therapy Against Cancer.

PURPOSE: Expanded research on the biomedical applications of graphene has shown promising results, although interactions between cells and graphene are still unclear. The current study aims to dissect the cellular and molecular effects of graphene nanocomposite in photothermal therapy against cancer, and to evaluate its efficacy. METHODS: In this study, a reduced graphene oxide and iron oxide (rGO-Fe3O4) nanocomposite was obtained by chemical synthesis. The nanocomposite was fully characterized by Raman spectroscopy, TEM, VSM and thermal profiling. Cell-nanocomposite interaction was evaluated by confocal microscopy and viability assays on cancer cell line HeLa. The efficacy of the thermal therapy and changes in gene expression of Bcl-2 and Hsp70 was assessed. RESULTS: The resulting rGO-Fe3O4 nanocomposite exhibited superparamagnetic properties and the capacity to increase the surrounding temperature by 18-20°C with respect to the initial temperature. The studies of cell-nanocomposite interaction showed that rGO-Fe3O4 attaches to cell membrane but there is a range of concentration at which the nanomaterial preserves cell viability. Photothermal therapy reduced cell viability to 32.6% and 23.7% with 50 and 100 µg/mL of nanomaterial, respectively. The effect of treatment on the molecular mechanism of cell death demonstrated an overexpression of anti-apoptotic proteins Hsp70 and Bcl-2 as an initial response to the therapy and depending on the aggressiveness of the treatment. CONCLUSION: The results of this study contribute to understanding the interactions between cell and graphene and support its application in photothermal therapy against cancer due to its promising results.

Thermal expansion effects and heat conduction in granular materials.

In this paper, we report results and analysis on a simulation study of the effects of thermal expansion in granular systems. We show that these effects impact the force distribution inside a two-dimensional system of disks that are subject to thermal heating under two different boundary conditions. A significant increase in the average force is observed for steel particles confined within a box with fixed walls at temperature rises of 50 degrees C and 100 degrees C, respectively. As previously noted in the literature, thermal expansion also induces compaction. The results show that a systematic and controllable increase in granular packing can be induced by simply raising and then lowering the temperature, without the input of mechanical energy in agreement with previous experimental observations. We find that the evolution of the packing fraction is well described by a fractional relaxation model, which follows the Mittag-Leffler law.

Eliminating segregation in free-surface flows of particles.

By introducing periodic flow inversions, we show both experimentally and computationally that forcing with a value above a critical frequency can effectively eliminate both density and size segregation. The critical frequency is related to the inverse of the characteristic time of segregation and is shown to scale with the shear rate of the particle flow. This observation could lead to new designs for a vast array of particle processing applications and suggests a new way for researchers to think about segregation problems.