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J Biomol Struct Dyn ; 38(1): 114-123, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-30688163

RESUMO

Deinococcus RecA (DrRecA) protein is a key repair enzyme and contributes to efficient DNA repair of Deinococcus radiodurans. Phosphorylation of DrRecA at Y77 (tyrosine 77) and T318 (threonine 318) residues modifies the structural and conformational switching that impart the efficiency and activity of DrRecA. Dynamics comparisons of DrRecA with its phosphorylated analogues support the idea that phosphorylation of Y77 and T318 sites could change the dynamics and conformation plasticity of DrRecA. Furthermore, docking studies showed that phosphorylation increases the binding preference of DrRecA towards dATP versus ATP and for double-strand DNA versus single-strand DNA. This work supporting the idea that phosphorylation can modulate the crucial functions of this protein and having good concordance with the experimental data. AbbreviationsDrRecADeinococcus RecADSBDNA double-strand breakshDNAheteroduplex DNASTYPKserine/threonine/tyrosine protein kinaseT318threonine 318Y77tyrosine 77Communicated by Ramaswamy H. Sarma.


Assuntos
Deinococcus/enzimologia , Deinococcus/efeitos da radiação , Tolerância a Radiação , Recombinases Rec A/química , Recombinases Rec A/metabolismo , Aminoácidos/química , Aminoácidos/metabolismo , Dano ao DNA , Reparo do DNA , DNA de Cadeia Simples , Modelos Moleculares , Fosforilação , Relação Estrutura-Atividade
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