Detalhe da pesquisa
1.
Investigation of the activity of a novel tropolone in osteosarcoma.
Drug Dev Res
; 85(1): e22129, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-37961833
2.
Evaluation of geranylgeranyl diphosphate synthase inhibition as a novel strategy for the treatment of osteosarcoma and Ewing sarcoma.
Drug Dev Res
; 84(1): 62-74, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36433690
3.
IL-17-CXC Chemokine Receptor 2 Axis Facilitates Breast Cancer Progression by Up-Regulating Neutrophil Recruitment.
Am J Pathol
; 190(1): 222-233, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31654638
4.
CXCR2 signaling promotes secretory cancer-associated fibroblasts in pancreatic ductal adenocarcinoma.
FASEB J
; 34(7): 9405-9418, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32453916
5.
In vivo evaluation of combination therapy targeting the isoprenoid biosynthetic pathway.
Pharmacol Res
; 167: 105528, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33667685
6.
Impact of α-modifications on the activity of triazole bisphosphonates as geranylgeranyl diphosphate synthase inhibitors.
Bioorg Med Chem
; 44: 116307, 2021 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34298413
7.
Amides as bioisosteres of triazole-based geranylgeranyl diphosphate synthase inhibitors.
Bioorg Med Chem
; 28(16): 115604, 2020 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32690260
8.
In Vivo Evaluation of Isoprenoid Triazole Bisphosphonate Inhibitors of Geranylgeranyl Diphosphate Synthase: Impact of Olefin Stereochemistry on Toxicity and Biodistribution.
J Pharmacol Exp Ther
; 371(2): 327-338, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31420526
9.
Novel benzimidazole phosphonates as potential inhibitors of protein prenylation.
Bioorg Med Chem Lett
; 29(24): 126757, 2019 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31699606
10.
ω-Hydroxy isoprenoid bisphosphonates as linkable GGDPS inhibitors.
Bioorg Med Chem Lett
; 29(19): 126633, 2019 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31474482
11.
CXCR2: A Novel Mediator of Mammary Tumor Bone Metastasis.
Int J Mol Sci
; 20(5)2019 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30871004
12.
Preclinical investigation of a potent geranylgeranyl diphosphate synthase inhibitor.
Invest New Drugs
; 36(5): 810-818, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29497895
13.
Semaphorin-5A maintains epithelial phenotype of malignant pancreatic cancer cells.
BMC Cancer
; 18(1): 1283, 2018 Dec 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30577767
14.
α-Methylation enhances the potency of isoprenoid triazole bisphosphonates as geranylgeranyl diphosphate synthase inhibitors.
Bioorg Med Chem
; 26(2): 376-385, 2018 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29248353
15.
Bishomoisoprenoid triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase.
Bioorg Med Chem
; 25(8): 2437-2444, 2017 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28302510
16.
Functional proteomic analysis reveals the involvement of KIAA1199 in breast cancer growth, motility and invasiveness.
BMC Cancer
; 14: 194, 2014 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24628760
17.
Geranylgeranyl diphosphate synthase inhibitor and proteasome inhibitor combination therapy in multiple myeloma.
Exp Hematol Oncol
; 11(1): 5, 2022 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35139925
18.
The Peptide-Drug Conjugate Melflufen Modulates the Unfolded Protein Response of Multiple Myeloma and Amyloidogenic Plasma Cells and Induces Cell Death.
Hemasphere
; 6(3): e687, 2022 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-35243210
19.
Role of chemokine receptor CXCR2 expression in mammary tumor growth, angiogenesis and metastasis.
J Carcinog
; 10: 40, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-22368515
20.
Small interfering RNA-mediated CXCR1 or CXCR2 knock-down inhibits melanoma tumor growth and invasion.
Int J Cancer
; 126(2): 328-36, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19585580