Translation and cross-cultural adaptation into Portuguese-Brazil of NuHISS, Enlight, and uMARS.

BACKGROUND: Easy access to the Internet enables the creation of many online applications. In this sense, questionnaires were developed to evaluate the usability of health area online applications: the National Usability-Focused Health Information System Scale (NuHISS), the Enlight, and the User Version of the Mobile Application Rating Scale (uMARS). Those scales do not have a Portuguese (Brazil) version which is adequate to Brazil's culture. As a consequence, they can not be properly used in Brazil. OBJECTIVE: To translate and cross-cultural adapt the NuHISS, Enlight, and uMARS to Portuguese (Brazil). METHODS: A methodological study involving the translation and cross-cultural adaptation of the questionnaires NuHISS, Enlight, and uMARS was conducted following international guidelines recommendations. The questionnaires pass trough an initial translation, translation synthesis, back translation, expert committee, and a pre-final version test. RESULTS: Thirdy-two health professionals analyzed NuHiss, Enlight, and uMARS translated and cross-cultural adapted Portuguese (Brazil) version. There was conceptual equivalence between the translated and original versions, and no significant adaptations were needed during the translation process. 93.8% of professionals assume that the language is cohesive and 96.9% of them consider that the content is cohesive. CONCLUSION: The NuHISS, Enlight, and uMARS were successfully translated and cross-culturally adapted to Portuguese (Brazil) and can be properly applied in Brazil. Brazilian health professionals should use the questionnaires NuHISS, Enlight, and uMARS to evaluate health area applications usability.

Helper T cell immunity in humans with inherited CD4 deficiency.

CD4+ T cells are vital for host defense and immune regulation. However, the fundamental role of CD4 itself remains enigmatic. We report seven patients aged 5-61 years from five families of four ancestries with autosomal recessive CD4 deficiency and a range of infections, including recalcitrant warts and Whipple's disease. All patients are homozygous for rare deleterious CD4 variants impacting expression of the canonical CD4 isoform. A shorter expressed isoform that interacts with LCK, but not HLA class II, is affected by only one variant. All patients lack CD4+ T cells and have increased numbers of TCRαß+CD4-CD8- T cells, which phenotypically and transcriptionally resemble conventional Th cells. Finally, patient CD4-CD8- αß T cells exhibit intact responses to HLA class II-restricted antigens and promote B cell differentiation in vitro. Thus, compensatory development of Th cells enables patients with inherited CD4 deficiency to acquire effective cellular and humoral immunity against an unexpectedly large range of pathogens. Nevertheless, CD4 is indispensable for protective immunity against at least human papillomaviruses and Trophyrema whipplei.

Adenoid cystic carcinoma in atypical site: case report

Adenoid cystic carcinoma (ACC) is a rare form of malignant neoplasm of the salivary glands, with slow growth and late symptoms. One of the challenges presented by this tumor is its high rate of metastasis, with tropism to the nervous system, liver and bones. Treatment is based on surgical resection of the tumor, radiotherapy, and chemotherapy ­ it varies depending on the condition of each patient. In view of the low frequency of ACC, this study aims to report a case of ACC in a female patient, with anatomopathological diagnosis of basaloid cell neoplasm

The relationship between risk factors for metabolic syndrome in the physically active elderly / A relação entre os fatores de risco para a síndrome metabólica em idosos fisicamente ativos

Aging has a significant impact on the decrease of lean body mass and physical activity level, being related to the reduction in basal metabolic rate and the increase of overweight and obesity in the elderly. The aim of this study is to identify correlations among the risk factors of metabolic syndrome (MS) from the measurement of abdominal perimeter (AP) and body mass index (BMI) with blood parameters for fasting blood glucose (FBG), total cholesterol (TC) and triglycerides (TG) in active elderly people. Measurements of weight and height were adopted to classify criteria by the World Health Organization (WHO) and to calculate BMI. The measurement of AP was done in centimeters. Blood parameters for FBG, TC, and TG were assessed by collecting blood from the fingertip and analyzing it using the Accutrend Plus (Roche) equipment. For data analysis, the Pearson correlation coefficient between anthropometric measures (independent variables) and blood parameters (dependent variables) was calculated. Simple linear regression was applied to the significant variables (0.05%). The BMI assessment shows 71% of the elderly were overweight and 34% were obese. Over the cut-off point recommended, 57% of the sample was indicated by AP. The correlation test shows evidence regarding the existence of a significant association between FBG and AP and also between AP and TG as compared to the use of BMI. The AP measurement seems to be an efficient indication of the relationship between risk factors for MS and should be incorporated into routines to assess the elderly as an indicator of abdominal obesity.

O envelhecimento tem um impacto significativo na diminuição de massa magra e do nível de atividade física, estando relacionado à redução na taxa metabólica basal e ao aumento de sobrepeso e obesidade em idosos. O objetivo deste estudo foi identificar correlações entre os fatores de risco da síndrome metabólica (SM) e a medição do perímetro abdominal (PA) e do índice de massa corporal (IMC) com os parâmetros sanguíneos de glicemia de jejum (GJ), colesterol total (CT) e triglicerídeos (TG) em idosos ativos. Para cálculo do IMC, foram coletadas medidas de peso e altura e adotados os critérios de classificação da Organização Mundial da Saúde (OMS). A medida do PA foi efetuada em centímetros. Os parâmetros sanguíneos de GJ, CT e TGL foram avaliados pelo método de coleta de sangue na ponta de dedo com leitura em equipamento Accutrend Plus (Roche). Para análise dos resultados, foi realizado o cálculo do coeficiente de correlação de Pearson entre as medidas antropométricas (variáveis independentes) e parâmetros sanguíneos (variáveis dependentes). A regressão linear simples foi aplicada sobre as variáveis significativas (0.05%). A avaliação do IMC mostrou que 71% dos idosos estavam acima do peso e 34% eram obesos. No ponto de corte recomendado, 57% da amostra foram indicados por PA. O teste de correlação mostrou evidências sobre a existência de uma associação significativa entre GJ e PA e também entre PA e TG em comparação ao uso do IMC. A medição de PA parece seruma indicação eficaz da relação entre os fatores de risco para a SM e deve ser incorporada nas rotinas para avaliar idosos como um indicador de obesidade abdominal.

The relationship between physical aspects of quality of life and extreme levels of regular physical activity in adults / Relação entre os aspectos físicos da qualidade de vida e níveis extremos de atividade física regular em adultos / Relación entre la calidad de vida y niveles extremos de actividad física regular en adultos

This study aimed to check for any significant differences in perceived quality of life, specifically aspects of a physical nature, among volunteers who are more physically active and those less physically active in a university community. The sample consisted of 1,966 volunteers in a university community in Brazil. To assess physical activity levels, volunteers responded to the International Physical Activity Questionnaire (IPAQ), and to analyse the perception of quality of life they responded to WHOQOL-bref, which is classified into three groups according to level of physical activity, taking into account the metabolic equivalent index (MET) over a full week. For comparison, consideration was given to the first and third tertiles, respectively, namely groups of more and less active students. The results indicated that individuals who engaged in more physical activity had a more positive perception of quality of life compared to those who were less active in physical aspects related to the ability to work, energy for day-to-day activities and locomotion.

O objetivo desse estudo foi avaliar a percepção da qualidade de vida, entre os voluntários mais fisicamente ativos e os menos fisicamente ativos de uma comunidade universitária. A amostra foi formada por 1.966 voluntários entre estudantes e servidores de uma comunidade universitária do Brasil. Para a avaliação do nível de atividade física foi utilizado o Questionário Internacional de Atividade Física (IPAQ) e para análise da percepção da qualidade de vida o WHOQOL-bref. Os participantes foram classificados em três grupos considerando o índice de equivalente metabólico (MET) ao longo de uma semana completa. A análise do nível de atividade física indicou, dentre os 1.966 avaliados, 51,5% ativos, 14% muito ativos, 21,3% insuficientemente ativo B; 4,7% insuficientemente ativo A e 5,8% sedentários. Os dados sugerem associação entre a prática da atividade física e percepção positiva da qualidade de vida nos aspectos do domínio físico que estão relacionados com a capacidade para o trabalho, energia para as atividades do dia a dia e locomoção.

El objetivo de este estudio fue comprobar la calidad de vida percibida por los voluntarios que son físicamente más activos y los menos activos en una comunidad universitaria. La muestra, constituida por 1.966 voluntarios, estaba formada por estudiantes y personal docente en una comunidad universitaria en Brasil. Para evaluar el nivel de actividad física, se utilizó Cuestionario Internacional de Actividad Física (IPAQ), y para la percepción de la calidad de vida: WHOQOL-bref. Los participantes se clasificaron en tres grupos, según el nivel de actividad física, teniendo en cuenta índice equivalente metabólico (MET) durante una semana completa. El nivel de actividad física mostró que la muestra se clasificó como un 51,5% activo; un 14% muy activo; B un 21,3% insuficientemente activo; un 4,7% insuficientemente activo A y un 5,8% eran sedentarios. Las personas que participan en más actividades físicas tenían una percepción más positiva de la calidad de vida, en los aspectos físicos relacionados con la capacidad de trabajo, energía para las actividades del día a día y la locomoción, en comparación con aquellos que eran menos activos.

Consumo alimentar, estado nutricional e nível de atividade física em comunidade universitária brasileira / Food intake, nutritional status and level of physical activity in a Brazilian university community

OBJETIVO: Este estudo teve como objetivo avaliar a variabilidade e a frequência do consumo alimentar, o estado nutricional e o nível de atividade física em uma comunidade universitária brasileira. MÉTODOS: A amostra constitui-se de 303 voluntários (130 homens e 173 mulheres) pertencentes à comunidade universitária do interior de São Paulo e avaliada por meio da disponibilização pela Internet do Questionário de Frequência Alimentar do International Physical Activity Questionaire e por meio da coleta da descrição autorreferida do peso e da altura. Foi realizada análise descritiva dos dados, análise de frequência alimentar e teste do coeficiente de correlação de Spearman. RESULTADOS: Foram observados inadequação dos hábitos alimentares, sobrepeso e obesidade na amostra estudada. As correlações entre os grupos alimentares apresentaram valores de magnitude maiores no grupo de mulheres que se alimentam de forma mais adequada do que os homens, mas não foram observadas diferenças entre os sexos no nível de atividade física. Não houve correlação significativa entre grupos de alimentos consumidos, índice de massa corporal e nível de atividade física em ambos os sexos. CONCLUSÃO: A comunidade universitária estudada apresentou baixo consumo de frutas, legumes e verduras, bem como consumo insuficiente de alimentos do grupo de cereais e leguminosas.

OBJECTIVE: This study assessed the food intake variability and frequency, nutritional status and level of physical activity of a university community in Brazil. METHODS: The sample comprised 303 volunteers (130 men and 173 women) from a university community in São Paulo state. They answered the International Physical Activity Questionnaire online and reported their weight and height. Statistical treatment included descriptive analysis, analysis of food intake frequency (Dietsys) and Spearman's rank correlation coefficient. RESULTS: Eating habits were inappropriate and many individuals were overweight or obese. There were more correlations among food groups for women who had better diets than men but the level of physical activity did not differ between the genders. There was no significant correlation between food groups and body mass index or level of physical activity for men or women. CONCLUSION: The study university community consumes little fruit, non-starchy vegetables, grains and legumes.

LABEL DESIGNING FOR MINIMALLY PROCESSED TILAPIA AIMING THE TRACEABILITY OF THE PRODUCTIVE CHAIN

The aim of this study was to develop label for Nile tilapia minimally processed. Analyses were performed to quantify the nutritional components of the fillets; and information about freshness, date of processing and batch specification was collected. Such data were essential for designing labels providing information about the traceability system and presenting codes for quality identification such as the Quick Response Code (QR Code), which allows the electronic encoding of the product on a database. Mandatory food labeling associated with the use of QR Code are tools that convey information to consumers about food quality and the entire production chain. One hundred sixty-two potential consumers were surveyed about the general characteristics of the product packaged in poly nylon film type, vacuum-packed, used for the packaging of traced fresh-cut fillets of tilapia minimally processed and kept under refrigeration (0±1oC). According to the Spearman correlation the variables packaging, general appearance and willingness to purchase the product presented a correlation, with coefficients estimated at 0.437, 0.466 and 0.497 respectively.

Fatores relacionados ao óbito de pacientes sépticos na Unidade de Terapia Intensiva

Introdução: A sepse é uma problemática constante nas Unidades de Terapia Intensiva (UTI) e importante causa de óbitos, com letalidade alta e crescente, configurando um desafio para profissionais em todo o globo. bjetivo: Identificar os fatores de risco relacionados ao óbito de pacientes com sepse sob cuidados intensivos. Materiais e métodos: Estudo retrospectivo, do tipo caso-controle, realizado na Fundação Pública Estadual Hospital das Clínicas Gaspar Vianna (FHCGV), Belém, Pará, por meio da coleta de dados em prontuários de pacientes sépticos internados na UTI adulto do FHCGV no período de 01 de janeiro a 31 de dezembro de 2016, considerando dois grandes grupos: caso, pacientes sépticos ou em choque séptico que evoluíram a óbito e controle, pacientes sépticos que receberam alta deste serviço. Utilizou-se o programas Microsoft Excel 2013 para a compilação dos dados e Minitab 18 para o tratamento estatístico. Foram definidos como estatisticamente significativos os valores de p 18mg/DL (p< 0,000) e média de hemoglobina 9,95±1,98 foram altamente preditivos para o óbito. Conclusão: Pacientes sépticos idosos apresentam quase 140 vezes mais chances de óbito que indivíduos mais jovens. Lactatemia, baixos valores de hemoglobina no diagnóstico e a evolução para o choque séptico representam importantes fatores de risco para o óbito

Introduction: Sepsis is a constant problem in Intensive Care Units (ICUs) and an important cause of death, with high and increasing lethality, posing a challenge for professionals across the globe. Objective: To identify the risk factors related to the death of patients with sepsis under intensive care. Materials and methods: A cross-sectional, retrospective, case-control study was performed at the Gaspar Vianna Hospital Public Clinics Foundation (FHCGV), Belém, Pará, Brazil, through the collection of data in medical records of septic patients admitted to the FHCGV adult ICU in the period from January 1 to December 31, 2016, considering two large groups: case, septic or septic shock patients who evolved to death and control, septic patients who were discharged from this service. We used the Microsoft Excel 2013 programs for data compilation and Minitab18 for statistical treatment. Values of p 18mg / DL (p <0.000) were highly predictive of death. Conclusion: Elderly septic patients present almost 140 times more chances of death than younger individuals, lactatemia in the diagnosis and the evolution to septic shock represent important risk factors for death