Detalhe da pesquisa
1.
Synthesis of 4-O-(4-Amino-4-deoxy-ß-D-xylopyranosyl)paromomycin and 4-S-(ß-D-Xylopyranosyl)-4-deoxy-4'-thio-paromomycin and Evaluation of their Antiribosomal and Antibacterial Activity.
Tetrahedron
; 1352023 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37035443
2.
Apralogs: Apramycin 5-O-Glycosides and Ethers with Improved Antibacterial Activity and Ribosomal Selectivity and Reduced Susceptibility to the Aminoacyltranserferase (3)-IV Resistance Determinant.
J Am Chem Soc
; 142(1): 530-544, 2020 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31790244
3.
Synthesis of a Pseudodisaccharide Suitable for Synthesis of Ring I Modified 4,5-2-Deoxystreptamine Type Aminoglycoside Antibiotics.
J Org Chem
; 85(11): 7583-7587, 2020 06 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32336094
4.
Predictive Analysis of the Side Chain Conformation of the Higher Carbon Sugars: Application to the Preorganization of the Aminoglycoside Ring 1 Side Chain for Binding to the Bacterial Ribosomal Decoding A Site.
J Org Chem
; 85(24): 16043-16059, 2020 12 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32902280
5.
Design, Multigram Synthesis, and in Vitro and in Vivo Evaluation of Propylamycin: A Semisynthetic 4,5-Deoxystreptamine Class Aminoglycoside for the Treatment of Drug-Resistant Enterobacteriaceae and Other Gram-Negative Pathogens.
J Am Chem Soc
; 141(12): 5051-5061, 2019 03 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30793894
6.
Structure-Based Design and Synthesis of Apramycin-Paromomycin Analogues: Importance of the Configuration at the 6'-Position and Differences between the 6'-Amino and Hydroxy Series.
J Am Chem Soc
; 139(41): 14611-14619, 2017 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28892368
7.
Influence of 4'-O-Glycoside Constitution and Configuration on Ribosomal Selectivity of Paromomycin.
J Am Chem Soc
; 137(24): 7706-17, 2015 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26024064
8.
Fluorine-decoupled carbon spectroscopy for the determination of configuration at fully substituted, trifluoromethyl- and perfluoroalkyl-bearing carbons: comparison with 19F-1H heteronuclear Overhauser effect spectroscopy.
J Org Chem
; 80(3): 1754-63, 2015 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-25561269
9.
Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin.
Proc Natl Acad Sci U S A
; 109(27): 10984-9, 2012 Jul 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22699498
10.
Synthesis of a pseudodisaccharide α-C-glycosidically linked to an 8-alkylated guanine.
Molecules
; 18(4): 3906-16, 2013 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-23549297
11.
Synthesis of Gentamicins C1, C2, and C2a and Antiribosomal and Antibacterial Activity of Gentamicins B1, C1, C1a, C2, C2a, C2b, and X2.
ACS Infect Dis
; 9(8): 1622-1633, 2023 08 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37481733
12.
Importance of Co-operative Hydrogen Bonding in the Apramycin-Ribosomal Decoding A-Site Interaction.
ChemMedChem
; 18(1): e202200486, 2023 01 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36198651
13.
Structure-activity relationships among the kanamycin aminoglycosides: role of ring I hydroxyl and amino groups.
Antimicrob Agents Chemother
; 56(12): 6104-8, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22948879
14.
Synthesis, Antibacterial and Antiribosomal Activity of the 3C-Aminoalkyl Modification in the Ribofuranosyl Ring of Apralogs (5-O-Ribofuranosyl Apramycins).
Antibiotics (Basel)
; 12(1)2022 Dec 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36671225
15.
Structure-Activity Relationships for 5'' Modifications of 4,5-Aminoglycoside Antibiotics.
ChemMedChem
; 17(13): e202200120, 2022 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35385605
16.
Autonomously pairing cysteinyl-linked nucleotide analogues with a unique architecture.
J Am Chem Soc
; 133(12): 4264-7, 2011 Mar 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-21384899
17.
Influence of ring size in conformationally restricted ring I analogs of paromomycin on antiribosomal and antibacterial activity.
RSC Med Chem
; 12(9): 1585-1591, 2021 Sep 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34671740
18.
Synthesis and Antibacterial Activity of Propylamycin Derivatives Functionalized at the 5''- and Other Positions with a View to Overcoming Resistance Due to Aminoglycoside Modifying Enzymes.
ACS Infect Dis
; 7(8): 2413-2424, 2021 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34114793
19.
An Advanced Apralog with Increased inâ vitro and inâ vivo Activity toward Gram-negative Pathogens and Reduced ex vivo Cochleotoxicity.
ChemMedChem
; 16(2): 335-339, 2021 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33007139
20.
Structural and biochemical evidence for a boat-like transition state in beta-mannosidases.
Nat Chem Biol
; 4(5): 306-12, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18408714