[The hemostatic system and correction of its impairments, by using the disaggregatory agent ticlopidine and low-molecular-weight heparin in patients with idiopathic fibrosing alveolitis].

The study was undertaken to examine the mechanisms of changes in the plasma and platelet links of hemostasis in patients with idiopathic fibrosing alveolitis in relation to the course of the disease and the possibilities of correcting the detected disorders with antiaggregatory and anticoagulative agents. Sixty-five patients were examined. All the patients were found to have the signs of hypercoagulation and a drastic change in the functional status of platelets. There was a relationship of the severity of impairments of hemocoagulation and platelet aggregation to the nature of a course of the disease. Addition of the antiaggregatory agent ticlopidine to the standard therapy exerted a normalizing impact on the functional status of platelets, which was more pronounced in the progressive course of the disease. The use of the low molecular-weight heparin fraxiparine had a beneficial effect on both components of the hemostatic system, which was more marked in the progressive course of idiopathic fibrosing alveolitis.

[Cerebral sarcoidosis: clinical aspects and course]. / Tserebral'nyi sarkoidoz, klinika i techenie.

Central nervous system sarcoidosis lesion is rare among patients with extrapulmonary tuberculosis. The lesion was encountered in 3 of the examined 120 patients with this condition. These 3 patients with cerebral sarcoidosis are used as an example to describe the clinical manifestations, diagnosis, and treatment of the disease. Its diagnosis is difficult. When such symptoms as fever, headache, thirst, etc., much alert is required in order to recognize CNS lesion as soon as possible. Its treatment has its own features.

[Long-term results of prolonged treatment in patients with fibrosing alveolitis (prophylactic medical examination)]. / Otdalennye ruzul'taty dlitel'nogo lecheniia bol'nykh fibroziruiushchimi al'veolitami (dispanserizatsiia).

The results of a long-term (5-10 year) follow-up were studied in 109 patients with alveolitis, including 89 with EAA and 20 with IFA. A variety of treatments were applied. The predominant treatments were hormonal therapy supplemented by plasmapheresis, physiotherapy, oxygen therapy, etc. A follow-up of patients with alveolitis was made by 3 groups. Group 1 was compensated--Stage 0; Group 2, subcompensated--Stage II; Group 3, decompensated--Stage III. The control periods and scope of examinations were defined for each group. The Regulations governing the prophylactic medical examination of patients with alveolitis were worked out. Among patients with EAA, good results, such as improvement and stabilization of the process, were observed in 34.8% of cases, poor results, such as recurrences were in 53.6%, death rates were 3%. Among patients with IFA, good results were achieved in 15% of cases, recurrences and progression were in 10 and 30.7%, respectively, death rates were 40%.

[Atypical and unfavorable variants in the course of sarcoidosis]. / Atipichnye i neblagopriiatnye varianty techeniia sarkoidoza.

Sarcoidosis with atypical clinical manifestations and a poor course accounts for 5.6% (78 individuals per 1400 patients). The paper describes the atypical manifestations of sarcoidosis (fever, hypereosinophilia, lymphocytosis, etc.) and its poor course, which are similar to those of lymphoproliferative diseases, fibrosing alveolitis-type sarcoidosis, infiltrative pneumonic forms). Each of the above manifestations has complex differentially diagnostic aspects.