Detalhe da pesquisa
1.
Bicyclic ß-Sheet Mimetics that Target the Transcriptional Coactivator ß-Catenin and Inhibit Wnt Signaling.
Angew Chem Int Ed Engl
; 60(25): 13937-13944, 2021 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33783110
2.
Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119.
Chembiochem
; 20(24): 2987-2990, 2019 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31680402
3.
Rfx2 is required for spermatogenesis in the mouse.
Genesis
; 53(9): 604-611, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26248850
4.
Solute carrier family 2 member 1 is involved in the development of nonalcoholic fatty liver disease.
Hepatology
; 57(2): 505-14, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22961556
5.
Development of a Series of Pyrrolopyridone MAT2A Inhibitors.
J Med Chem
; 67(6): 4541-4559, 2024 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38466661
6.
Sirtuin 1 regulation of developmental genes during differentiation of stem cells.
Proc Natl Acad Sci U S A
; 107(31): 13736-41, 2010 Aug 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-20631301
7.
Impaired Function of Solute Carrier Family 19 Leads to Low Folate Levels and Lipid Droplet Accumulation in Hepatocytes.
Biomedicines
; 11(2)2023 Jan 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-36830876
8.
Targeting DNA damage response components induces enhanced STING-dependent type-I IFN response in ATM deficient cancer cells and drives dendritic cell activation.
Oncoimmunology
; 11(1): 2117321, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36117525
9.
Optimization of hERG and Pharmacokinetic Properties for Basic Dihydro-8H-purin-8-one Inhibitors of DNA-PK.
ACS Med Chem Lett
; 13(8): 1295-1301, 2022 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35978693
10.
HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis.
Gastroenterology
; 138(5): 1943-53, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20102719
11.
Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis.
Hepatology
; 52(5): 1621-31, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20815019
12.
Fragment-Based Design of a Potent MAT2a Inhibitor and in Vivo Evaluation in an MTAP Null Xenograft Model.
J Med Chem
; 64(10): 6814-6826, 2021 05 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-33900758
13.
Liquid chromatography-mass spectrometry-based parallel metabolic profiling of human and mouse model serum reveals putative biomarkers associated with the progression of nonalcoholic fatty liver disease.
J Proteome Res
; 9(9): 4501-12, 2010 Sep 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-20684516
14.
Evidence for LKB1/AMP-activated protein kinase/ endothelial nitric oxide synthase cascade regulated by hepatocyte growth factor, S-adenosylmethionine, and nitric oxide in hepatocyte proliferation.
Hepatology
; 49(2): 608-17, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19177591
15.
Impaired liver regeneration in mice lacking glycine N-methyltransferase.
Hepatology
; 50(2): 443-52, 2009 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19582817
16.
A protein tertiary structure mimetic modulator of the Hippo signalling pathway.
Nat Commun
; 11(1): 5425, 2020 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-33110077
17.
The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor.
J Med Chem
; 63(7): 3461-3471, 2020 04 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31851518
18.
Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice.
Hepatology
; 47(4): 1191-9, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18318442
19.
AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity.
Nat Commun
; 10(1): 5065, 2019 11 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31699977
20.
Combining mouse embryonic stem cells and zebrafish embryos to evaluate developmental toxicity of chemical exposure.
Reprod Toxicol
; 81: 220-228, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30103011