[Tables of composition of prepared foods for patients on hemodialysis]. / Tablice sastava pripremljene hrane za bolesnike na hemodijalizi.

Numerous mutually contradictory conditions in diets for haemodialysis patients require knowledge about the composition of prepared food for each individual patient. The aim of this study was to make appropriate tables of prepared food on the basis of the analysis of patients nutrition. A list of the food way of its preparation was formed after dietary interviews. The most frequent food was prepared in the usual way and its composition was computed with food tables. The tables of prepared food composition facilitate the prescription of dietary daily meals, and make the therapy easier.

[Plasma glucose, serum insulin and C-peptide in patients with various stages of chronic renal failure]. / Glikemija, insulinemija i ce-peptidemija kod bolesnika s razlicitim stepenom bubrezne insuficijencije.

Plasma glucose, serum insulin and C-peptide were measured in patients with various stages of chronic renal failure (CRF). In this study we observed 50 patients: 26 women and 24 men, between the ages of 17 and 73. Following various stages of CRF our patients were devided into IV groups, with 10 patients in each. V-th group was control group with 10 healthy persons. Plasma glucose, serum insulin and C-peptide were measured in the fasting state and following the 2 hours oral glucose tolerance test (OGTT). In the fasting state, plasma glucose and serum insulin levels were normal in all groups. With deterioration of the renal function plasma glucose and serum insulin increased slower during OGTT but their levels also decreased slower. Fasting levels of C-peptide increased continually with deterioration of renal function in all patients and values were significantly higher than in control group.

[Characteristics of renal failure in chronic liver disease]. / Karakteristike bubrezne insuficijencije u hronicnih oboljenjima jetra.

The aim of this study was to establish the characteristics of renal failure in patients with cirrhosis and compare their laboratory data on blood and urine with those of patients with chronic renal failure without liver disease; and then to correlate the data of patients with cirrhosis and renal failure with that of patients with cirrhosis without renal failure in relation to liver function There were three groups of patients: group A - patients with cirrhosis and renal failure; group K1-patients with cirrhosis without renal failure; and group K2-patients with chronic renal failure. The parameters of renal and liver function were also compared. The laboratory data on blood and urine in patients with cirrhosis and renal failure revealed characteristics of prerenal failure in a higher degree (functional renal failure). When liver failure was concerned there was no difference between patients with cirrhosis and renal failure and subjects with cirrhosis and no renal failure. The degree of renal failure was not always the same regarding the degree of liver failure although they can sometimes paralell.

Spontaneous blastogenesis profiles and IL-2 receptor expression on kidney allograft.

To examine immune activation rate of interstitial and glomeruli infiltrating MNC in different conditions of human renal allograft function deterioration, 33 renal transplant biopsies were performed 1-30 months after transplantations. Forty-one patients observed were on immunosuppressives: Pr, Aza, CsA following renal transplantation from a living-related donor parent. The patients were divided according to their histologic diagnosis into the following groups: 1, 15 pts in acute rejection attack (AR); 2, 10 pts with cyclosporine nephrotoxicity (CsN); 3, 10 pts with chronic vascular rejecting kidney (ChR). A conventional histologic investigation and immunohistochemical analyses of CD3 and CD25 molecules were performed in groups 1-3. Spontaneous blastogenesis (SB) of peripheral lymphocytes was simultaneously determined and compared with the controls (C)-30 healthy people, and with patients with stable renal allograft function (S)-8 pts. The highest IL-2R expression on diffuse or focal dense MNC infiltrates in interstitium was observed during AR, without IL-2R+ MNC in glomeruli. Low to moderate focal interstitial infiltrates in damaged areas of renal parenchyma due to CsN, were IL-2R negative. In ChR, moderate IL-2R expression was observed on interstitial spare mild or focal dense MNC infiltrates with IL-2R expression present on glomeruli infiltrating MNC. Significant increases of SB values were recorded during the first week after transplantation and AR in comparison to C. The highest SB values were in ChR group. Values of SB in CsN and S were on the C and before transplantation levels.(ABSTRACT TRUNCATED AT 250 WORDS)

Laminin, fibronectin, and Goodpasture antigen detection in patients with Alport's syndrome.

Indirect immunofluorescence study with laminin and fibronectin monoclonal antibodies on paraffin sections, as well as with serum from a patient with Goodpasture's syndrome with high titer of autoantibodies that recognize the antigenic determinants in human glomerular and tubular basement membrane, was performed on 14 patients with Alport's syndrome and 5 specimens of normal renal tissue obtained from donors in cases of renal transplantation (control group). We found no binding of Goodpasture antigen to glomerular and distal tubular basement membranes in renal biopsy tissue from all 14 patients with Alport's syndrome. In contrast, there was bright linear fluorescence of Goodpasture antigen on glomerular and tubular basement membranes of normal renal material. There was no difference in laminin and fibronectin binding in patients with Alport's syndrome and controls. In all the cases binding was strongly positive. These results suggest an abnormality or absence of immunoreactive autoantigen in the glomerular and distal tubular basement membrane in patients with Alport's syndrome. Therefore, Goodpasture antigen detection could be an important diagnostic method in early stages of Alport's syndrome when characteristic morphological changes are not yet developed.