RESUMO
Five unusual cases of retinal detachment were caused by giant (more than 90 degrees) posterior breaks in the outer layer of degenerative retinoschisis. All retinas were successfully reattached by a variety of surgical techniques. The two cases managed with scleral buckling required subsequent buckle removal because of macular distortion. Treatment with cryotherapy or laser, together with intraocular air and postoperative positioning, gave better anatomic results.
Assuntos
Degeneração Retiniana/patologia , Descolamento Retiniano/patologia , Perfurações Retinianas/patologia , Feminino , Angiofluoresceinografia , Humanos , Masculino , Pessoa de Meia-Idade , Retina/patologia , Descolamento Retiniano/cirurgia , Recurvamento da Esclera , Acuidade VisualAssuntos
Ácido Hialurônico/uso terapêutico , Hifema/tratamento farmacológico , Retina/cirurgia , Corpo Vítreo/cirurgia , Adulto , Corpos Estranhos no Olho/cirurgia , Traumatismos Oculares/cirurgia , Humanos , Cuidados Intraoperatórios , Masculino , Pessoa de Meia-Idade , Descolamento Retiniano/cirurgiaRESUMO
Vitreous amyloid may be the presenting clinical manifestation of types 1 and 2 familial amyloidotic polyneuropathy or complicate the course of these syndromes. Recent studies have shown that the major subunit protein composing amyloid fibrils in these conditions is a variant or abnormal prealbumin molecule and that affected individuals have low levels of this protein in their blood. The authors studied material obtained at vitrectomy from two cases of vitreous amyloid. One of these was nonfamilial and the other familial. Two-dimensional gels of solubilized protein from pelleted and washed vitreous amyloid in both cases were found to consist of material with the molecular weight and isofocusing coordinates of prealbumin monomer. Reactivity of fibrils with a monospecific antiserum to prealbumin was confirmed by colloidal gold immunoelectron microscopy. Non-familial as well as familial vitreous amyloid may in fact be systemic forms of amyloidosis due to deposition of prealbumin which can be characterized by biochemical or immunohistologic studies of material obtained at vitrectomy.