RESUMO
BACKGROUND: Chromoblastomycosis is a chronic fungal infection of the skin and subcutaneous tissues caused by different melanized fungi. The disease occurs worldwide, particularly in tropical and subtropical regions but not reported in Vietnam. A 47-year-old women was admitted to hospital 103, Hanoi, Vietnam, with a 10-year lasting lesion on backside of her right shank. Diagnosis of chromoblastomycosis was made after discovery of a muriform cell in histopathological examination. A black, slow-growth fungus was isolated and identified as Fonsecaea pedrosoi after molecular analysis. After 1-month treatment with itraconazole, the lesion has significant improvement. CONCLUSION: This is the first case of chromoblastomycosis caused by Fonsecaea pedrosoi reported in Vietnam.
Assuntos
Ascomicetos/isolamento & purificação , Cromoblastomicose/diagnóstico , Cromoblastomicose/patologia , Perna (Membro)/patologia , Antifúngicos/administração & dosagem , Ascomicetos/crescimento & desenvolvimento , Cromoblastomicose/tratamento farmacológico , Cromoblastomicose/microbiologia , Feminino , Histocitoquímica , Humanos , Itraconazol/administração & dosagem , Técnicas Microbiológicas , Microscopia , Pessoa de Meia-Idade , Técnicas de Diagnóstico Molecular , Resultado do Tratamento , VietnãRESUMO
The emergence of Dirofilarial infections in Asia including Vietnam is a clinically significant threat to the community. We here report a rare case of subcutaneous Dirofilaria repens infection on the posterior thoracic wall in a young woman presenting a painful, itchy, and palpable nodule. The adult worm was identified by mitochondrial cox1 and nuclear ITS-2 sequence determination. The diagnosis was additionally confirmed by 16S rRNA sequencing of the endosymbiont Wolbachia pipientis commonly co-existing with D. repens. This is a rare case of subcutaneous human infection on the posterior thoracic region caused by D. repens.