Detalhe da pesquisa
1.
Pharmacological disruption of the Notch transcription factor complex.
Proc Natl Acad Sci U S A
; 117(28): 16292-16301, 2020 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32601208
2.
Prenatal Correction of X-Linked Hypohidrotic Ectodermal Dysplasia.
N Engl J Med
; 378(17): 1604-1610, 2018 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29694819
3.
A mouse model of systemic lupus erythematosus responds better to soluble TACI than to soluble BAFFR, correlating with depletion of plasma cells.
Eur J Immunol
; 47(6): 1075-1085, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28383107
4.
Antibodies That Block or Activate Mouse B Cell Activating Factor of the Tumor Necrosis Factor (TNF) Family (BAFF), Respectively, Induce B Cell Depletion or B Cell Hyperplasia.
J Biol Chem
; 291(38): 19826-34, 2016 09 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-27451394
5.
Stoichiometry of Heteromeric BAFF and APRIL Cytokines Dictates Their Receptor Binding and Signaling Properties.
J Biol Chem
; 290(26): 16330-42, 2015 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25953898
6.
The Efficacy of CB-103, a First-in-Class Transcriptional Notch Inhibitor, in Preclinical Models of Breast Cancer.
Cancers (Basel)
; 15(15)2023 Aug 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37568775
7.
A Phase I Study of the Pan-Notch Inhibitor CB-103 for Patients with Advanced Adenoid Cystic Carcinoma and Other Tumors.
Cancer Res Commun
; 3(9): 1853-1861, 2023 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37712875
8.
CB-103: A novel CSL-NICD inhibitor for the treatment of NOTCH-driven T-cell acute lymphoblastic leukemia: A case report of complete clinical response in a patient with relapsed and refractory T-ALL.
EJHaem
; 3(3): 1009-1012, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-36051082
9.
Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells.
Cell Rep
; 38(13): 110583, 2022 03 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-35354034
10.
Methods for the Administration of EDAR Pathway Modulators in Mice.
Methods Mol Biol
; 2248: 167-183, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33185875
11.
Targeting Notch Inhibitors to the Myeloma Bone Marrow Niche Decreases Tumor Growth and Bone Destruction without Gut Toxicity.
Cancer Res
; 81(19): 5102-5114, 2021 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34348968
12.
No interactions between heparin and atacicept, an antagonist of B cell survival cytokines.
Br J Pharmacol
; 176(20): 4019-4033, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31355456
13.
Inhibition of Membrane-Bound BAFF by the Anti-BAFF Antibody Belimumab.
Front Immunol
; 9: 2698, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30524439
14.
A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors.
Nat Commun
; 9(1): 1199, 2018 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-29572442