Detalhe da pesquisa
1.
Therapeutic implications of tumor interstitial acidification.
Semin Cancer Biol
; 43: 119-133, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28188829
2.
Potency prediction of ß-secretase (BACE-1) inhibitors using density functional methods.
J Chem Inf Model
; 54(3): 818-25, 2014 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24456077
3.
Ligand-based design of [18F]OXD-2314 for PET imaging in non-Alzheimer's disease tauopathies.
Nat Commun
; 15(1): 5109, 2024 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38877019
4.
Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy.
Mol Oncol
; 2024 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38506049
5.
Synthesis and structure-activity relationship of 4-(1,3-benzothiazol-2-yl)-thiophene-2-sulfonamides as cyclin-dependent kinase 5 (cdk5)/p25 inhibitors.
Bioorg Med Chem Lett
; 22(18): 5919-23, 2012 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22889803
6.
Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti-PD-1/PD-L1 immunotherapy.
Sci Adv
; 6(18): eaax7881, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32494661
7.
Liver X receptor agonists with selectivity for LXRbeta; N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides.
Bioorg Med Chem Lett
; 19(7): 2009-12, 2009 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19264481
8.
Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib.
Cancer Lett
; 435: 32-43, 2018 10 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30055290
9.
Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design.
J Med Chem
; 61(6): 2533-2551, 2018 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29485874
10.
Pathobiology and Therapeutic Implications of Tumor Acidosis.
Curr Med Chem
; 24(26): 2827-2845, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28031009
11.
Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target.
ACS Chem Biol
; 12(8): 1986-1992, 2017 08 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28679043
12.
Creation of Novel Cores for ß-Secretase (BACE-1) Inhibitors: A Multiparameter Lead Generation Strategy.
ACS Med Chem Lett
; 5(4): 440-5, 2014 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900855
13.
Core refinement toward permeable ß-secretase (BACE-1) inhibitors with low hERG activity.
J Med Chem
; 56(11): 4181-205, 2013 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23126626
14.
New aminoimidazoles as ß-secretase (BACE-1) inhibitors showing amyloid-ß (Aß) lowering in brain.
J Med Chem
; 55(21): 9297-311, 2012 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23017051
15.
Design and synthesis of 2'-anilino-4,4'-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3.
Bioorg Med Chem Lett
; 16(5): 1397-401, 2006 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16337120
16.
Design and synthesis of 6-anilinoindazoles as selective inhibitors of c-Jun N-terminal kinase-3.
Bioorg Med Chem Lett
; 15(22): 5095-9, 2005 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16140012