Detalhe da pesquisa
1.
Clinical targeting of HIV capsid protein with a long-acting small molecule.
Nature
; 584(7822): 614-618, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32612233
2.
Protein Footprinting and X-ray Crystallography Reveal the Interaction of PD-L1 and a Macrocyclic Peptide.
Biochemistry
; 59(4): 541-551, 2020 02 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31841311
3.
Evaluation of Free Energy Calculations for the Prioritization of Macrocycle Synthesis.
J Chem Inf Model
; 60(7): 3489-3498, 2020 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32539379
4.
Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi®.
Bioorg Med Chem Lett
; 29(16): 2428-2436, 2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31133531
5.
Biochemical characterization and structure determination of a potent, selective antibody inhibitor of human MMP9.
J Biol Chem
; 292(16): 6810-6820, 2017 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28235803
6.
Discovery of potent and selective inhibitors of calmodulin-dependent kinase II (CaMKII).
Bioorg Med Chem Lett
; 28(3): 541-546, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29254643
7.
Structural, biochemical, and biophysical characterization of idelalisib binding to phosphoinositide 3-kinase δ.
J Biol Chem
; 290(13): 8439-46, 2015 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-25631052
8.
Nanolitre-scale crystallization using acoustic liquid-transfer technology.
Acta Crystallogr D Biol Crystallogr
; 68(Pt 8): 893-900, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22868754
9.
Acoustic matrix microseeding: improving protein crystal growth with minimal chemical bias.
Acta Crystallogr D Biol Crystallogr
; 66(Pt 5): 568-76, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20445232
10.
X-ray crystal structure of JNK2 complexed with the p38alpha inhibitor BIRB796: insights into the rational design of DFG-out binding MAP kinase inhibitors.
Bioorg Med Chem Lett
; 20(17): 5217-20, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20655210
11.
Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-benzyl derivatives with broad potency against resistant mutant viruses.
Bioorg Med Chem Lett
; 20(14): 4215-8, 2010 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20538456
12.
Exploration of piperidine-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-Phenyl derivatives with broad potency against resistant mutant viruses.
Bioorg Med Chem Lett
; 20(20): 6020-3, 2010 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20829038
13.
Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B.
J Med Chem
; 63(18): 10188-10203, 2020 09 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32407112
14.
Atropisomerism by Design: Discovery of a Selective and Stable Phosphoinositide 3-Kinase (PI3K) ß Inhibitor.
J Med Chem
; 61(15): 6858-6868, 2018 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30015489
15.
Discovery of Orally Efficacious Phosphoinositide 3-Kinase δ Inhibitors with Improved Metabolic Stability.
J Med Chem
; 59(19): 9228-9242, 2016 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27660855
16.
2,4,6-Triaminopyrimidine as a Novel Hinge Binder in a Series of PI3Kδ Selective Inhibitors.
J Med Chem
; 59(7): 3532-48, 2016 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26980109
17.
Discovery of N-[4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a potent inhibitor of the hepatitis C virus NS5B polymerase.
J Med Chem
; 57(5): 1914-31, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24195700
18.
Pyrrolopyrazines as selective spleen tyrosine kinase inhibitors.
J Med Chem
; 56(4): 1677-92, 2013 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23350847
19.
Rational design of highly selective spleen tyrosine kinase inhibitors.
J Med Chem
; 55(23): 10414-23, 2012 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23151054
20.
Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures.
Protein Sci
; 20(2): 428-36, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21280133