AYURAKSHA, a prophylactic Ayurvedic immunity boosting kit reducing positivity percentage of IgG COVID-19 among frontline Indian Delhi police personnel: A non-randomized controlled intervention trial.

Objective: The world continues to face the COVID-19 crisis, and efforts are underway to integrate traditional medicine interventions for its effective management. The study aimed to determine the efficacy of the "AYURAKSHA" kit in terms of post-interventional percentage of COVID-19 IgG positivity, immunity levels, and quality of life (QoL) against COVID-19. Method: This was a non-randomized controlled, prospective intervention trial, done after the distribution of 80,000 AYURAKSHA kits (constituent of Sanshamani Vati, AYUSH Kadha, and Anu Taila) among Delhi police participants in India. Among 47,827 participants, the trial group (n = 101) was evaluated with the positivity percentage of IgG COVID-19 and Immune Status Questionnaire (ISQ) scores as a primary outcome and the WHO Quality of Life Brief Version (QOL BREF) scores along with hematological parameters as a secondary outcome in comparison to the control group (n = 71). Results: The data showed that the percentage of COVID-19 IgG positivity was significantly lower in the trial group (17.5 %) as compared to the control group (39.4 %, p = 0.003), indicating the lower risk (55.6%) of COVID-19 infection in the trial group. The decreased incidence (5.05%) and reduced mortality percentage (0.44%) of COVID-19 among Delhi police officers during peak times of the pandemic also corroborate our findings. The ISQ score and WHO-QOL BREF tool analysis showed the improved scores in the trial group when compared with the controls. Furthermore, no dysregulated blood profile and no increase in inflammation markers like C-reactive protein, erythrocyte sedimentation rate, Interleukin-6 (IL-6) were observed in the trial group. However, significantly enhanced (p = 0.027) IL-6 levels and random blood sugar levels were found in the control group (p = 0.032), compared to a trial group (p = 0.165) post-intervention. Importantly, the control group showed more significant (p = 0.0001) decline in lymphocyte subsets CD3+ (% change = 21.04), CD4+ (% change = 20.34) and CD8+ (% change = 21.54) levels than in trial group, confirming more severity of COVID-19 infection in the control group. Conclusion: The AYURAKSHA kit is associated with reduced COVID-19 positivity and with a better quality of life among the trial group. Hence, the study encourages in-depth research and future integration of traditional medicines for the prevention of the COVID-19 pandemic. Clinical trial registration: http://ctri.nic.in/, identifier: CTRI/2020/05/025171.

An experimental study to evaluate the effect of Nitya Sevaniya (daily consumable) and Nitya Asevaniya (daily non-consumable) food items on albino rats.

BACKGROUND: As per Ayurveda, Nitya Sevaniya (NS) food items are recommended for daily intake while Nitya Asevaniya (NAS) food items should be avoided for daily intake due to their systemic wholesome and unwholesome effects after consumption, respectively. AIM AND OBJECTIVES: The present study was conducted to perform in vivo safety evaluation of selected Nitya Sevaniya and Nitya Asevaniya food items. MATERIALS AND METHODS: Thirty rats were randomly divided into five groups-each containing six Charle's Foster strain albino rats. Group 1 served as standard diet group, groups 2 and 3 served as test drug received groups namely NS50 and NS100, in which 50% and 100% mixture of Nitya Sevaniya food was administered, respectively. Group 4 and 5 as test drug received groups Nitya Asevaniya 50 (NAS50) and Nitya Asevaniya 100 (NAS100), in which 50% and 100% Nitya Asevaniya food mixtures was administered, respectively. The test diet was administered orally in the form of freshly prepared pellet twice a day ad libitum for 90 days. Parameters studied were gross behavior, body and organ weight, food and water intake, fecal and urine output, hematological and biochemical parameters, electrocardiogram and histology of various organs. RESULTS: In the NAS100 group, a significant change was observed in 20 of 47 parameters in view of pathological aspect. Among them, three parameters, i.e., platelet count, serum glutamic-oxaloacetic transaminase (SGOT) and indirect bilirubin were above normal limits, while other parameters were within the normal limits. No significant change was observed in any of the parameters in the NS50 and NS100 group after 90 days of administration as compared with the control group. CONCLUSION: Considering findings of this study, it is concluded that selected NS food items are safe while consumption of only selected Nitya Asevaniya food items (when administered in 100% dose) for 90 days have the potential of inflammatory changes in the liver, spleen; fat deposition in kidney and impairment of cardiac and renal functions.

Efficacy of Sattvavajaya Chikitsa in the form of relaxation techniques and Guda Pippalimula Churna in the management of Anidra (insomnia) - An open labelled, randomized comparative clinical trial.

BACKGROUND: Condition of insomnia may not be a life-threatening illness, but it has tendency to damage the person's daily life. In the current era of modernization, most of the person are is suffering from stress either it is personal or professional. Stress may cause sleeping problems or make existing problems worse. Sattvavajaya Chikitsa is a specialized type of treatment influencing the psychological aspect of body. It can be applied in the form of Yogic practices and other mind control techniques. With this research interest, the present study has been undertaken to assess the efficacy of the Sattvavajaya Chikitsa in the form of relaxation techniques (RT) and Guda Pippalimula Churna in Anidra (insomnia). OBJECTIVES: The objective of the study was to evaluate the efficacy of Sattvavajaya Chikitsa in the form of RT and Guda Pippalimula Churna in Anidra. MATERIALS AND METHODS: The study was an open-labeled randomized clinical trial in which sixty patients having symptoms of Anidra belonging to the age group of 20-60 years were enrolled and received Sattvavajaya Chikitsa (RT) and Guda Pippalimula Churna orally in 2gm dosage with jaggery for 28 days. The assessment of symptoms was done on the basis of relief in the scores given to signs and symptoms according to their severity. RESULTS: Both the groups showed significant results in chief as well as associated symptoms of disease. Regarding overall effect of therapy in both the groups, marked improvement is high followed by moderate improvement. No adverse reactions were documented. CONCLUSION: Sattvavajaya Chikitsa and Guda Pippalimula Churna are effective on Anidra, but Sattvavajaya Chikitsa was found more effective in reducing Manasa symptoms such as Chinta (tension), Bhaya (fear) and Krodha (anger).

Diet and lifestyle-related factors associated with Apathyanimittaja Prameha (type 2 diabetes): A cross-sectional survey study.

BACKGROUND: Lifestyle disorders are the leading cause of death and disability worldwide. Type 2 diabetes is one such disease with high incidence in low- and middle-income countries such as India. Changed lifestyle, lack of exercise, increased consumption of fatty, fast-food items, improper dietary habits and sedentary life are the main contributory factors for this, which are showing upward trend in India. AIMS AND OBJECTIVES: The aim of the study is to identify the lifestyle factors, physical activities and psychological factors associated with type 2 diabetes among the patient aged between 20-60 years. MATERIALS AND METHODS: A cross-sectional survey study was conducted on selected 150 patients of type 2 diabetes within 1 year of diagnosis. A survey questionnaire was used to collect the data for fulfilling the aims and objectives of the study. RESULTS AND OBSERVATIONS: 150 patients of type 2 diabetes were observed on various dietary factors, physical activities and life style factors. CONCLUSION: On the basis of survey psychological factor association with type 2 diabetes and dietary factors, physical activities and psychological factors observed in survey study. The obtained data exposed that intake of heavy, high fatty food, physical inactivity, day sleep and psychological distress as the main lifestyle factors associated with type 2 diabetes.

Hypolipidemic effect of Rukshana Upakrama in the management of dyslipidemia - A case study.

An elevated total or low-density lipoprotein (LDL) cholesterol levels or low levels of high-density lipoprotein (HDL) cholesterol is defined as dyslipidemia which is an important risk factor for coronary artery diseases (CADs) and strokes. It is estimated that abnormal cholesterol levels in the blood lead to cause about 18% of cardio vascular diseases (CVDs) and 56% of the ischemic heart diseases at global level. In comparison with others, South Asians have the highest incidence rate of CADs. Acharya Charaka has mentioned Rukshana Upakrama (a type of management which induces dryness) as one amongst the Shad-Upakrama (six principles of management) and can be considered as the best for the reduction of increased Kapha Dosha, Meda Dhatu (adipose tissue) and their related morbid factors. A 42-year-old female patient visited the OPD of the department of Basic Principles, IPGT and RA, Jamnagar, Gujarat, with the complaints of weight gain, heaviness in the body and lethargy. After investigation, she was diagnosed as a case of dyslipidemia due to abnormality in cholesterol levels. She was treated with Takra-Siddha Yavagu (gruel prepared with buttermilk) and Udvartana (dry powder massage) for 30 days. After completion of treatment, hematological investigations revealed that her serum cholesterol level was decreased to 147 mg/dl from 223 mg/dl and serum LDL was reduced to 91 mg/dl from 153 mg/dl. Her weight also reduced to 82 kgs from 88 kgs. Hence, it can be concluded that Rukshana Upakrama in the form of Takra-Siddha Yavagu and Udvartana is effective in the management of dyslipidemia for normalization of lipid in the blood as it possesses Shoshana (absorption) and Kapha-Medohara (alleviation of vitiated Kapha and Meda) properties.

Self-controlled clinical trial to evaluate the efficacy of Mukhakantivardhaka Lepa and Patoladi Ghanavati in Twakvaivarnya (hypermelanosis).

BACKGROUND: Beauty is not only a source of joy but also gives confidence to some extent. Ayurvedic cosmetology starts from mother's womb and continues with Dinacharya (daily routines), Ratricharya (diet and regimen for night), Ritucharya (seasonal diet and regimen), etc. The symbiosis between cosmetology and Ayurveda is the most ancient one. With this research interest, the present study has been undertaken to assess the efficacy of Mukhakantivardhaka Lepa and Patoladi Ghanavati in Tvakvaivarnya (hypermelanosis). OBJECTIVES: To evaluate the efficacy of Mukhakantivardhaka Lepa and Patoladi Ghanavati in Tvakvaivarnya (hypermelanosis). MATERIALS AND METHODS: This study was a double-armed clinical trial in which 62 patients having signs and symptoms of Tvakvaivarnya were selected belonging to the age group of 16-40 years and received Mukhakantivardhaka Lepa and Patoladi Ghanavati for 60 days with follow-up after every week. For the purpose of perfect diagnosis and assessment of all aspects of the disease, a special research proforma was prepared. RESULTS: Both the groups showed 100% improvment in associated symptoms. Regarding the overall effect of therapy in both the groups, moderate improvement was high following marked improvement. No adverse reactions were documented. CONCLUSION: Mukhakantivardhaka Lepa and Patoladi Ghanavati work excellently on Tvakvaivarnya (hypermelanosis) and improve skin complexion.

Lifestyle related factors associated with Sthaulya (obesity) - A cross-sectional survey study.

INTRODUCTION: The burden of lifestyle disorders is rapidly increasing worldwide. Modernization, affluence, science and technological development lead to still more sedentary life styles. By exposing oneself to all these factors human being unknowingly invited a number of diseases, out of which Sthaulya (obesity) is one which disturbs physical, mental and social health of an individual. AIMS AND OBJECTIVES: To identify the main lifestyle related Aharatmaka (dietary factors), Viharatmaka (physical activities) and Manasika (psychological) factors associated with Sthaulya (obesity) among the patient aged in between 20-60 years. MATERIAL AND METHODS: Cross-sectional survey study was done among 250 patients of Sthaulya (obesity) visiting outpatient department of the Institute from the period May 2013 to June 2014. The patients were selected using simple random sampling method. Ethical clearance was obtained from the Institute and Lifestyle related questionnaire was used for survey study which was based on the etiological factors mentioned in the Ayurvedic classics. OBSERVATIONS AND CONCLUSIONS: The survey study revealed that intake of Guru and Snigdha Ahara (heavy fatty food), Avyayama (lack of involvement in physical activities), Divasvapna (day sleep) and psychological distress are the main lifestyle related factors strongly associated with the Sthaulya (Obesity).

Rasayana effect of Guduchi Churna on the life span of Drosophila melanogaster.

INTRODUCTION: The Drosophila melanogaster is one of the most extensively studied animal models for understanding the process of aging and longevity. This fly is being used for genetic studies since almost a century. Guduchi (Tinospora cordifolia [Wild.] Miers.) is an Ayurvedic drug used as Rasayana (rejuvenation) due to its antiaging effect. AIM: To explore the potential of Guduchi Churna (powder of T. cordifolia) on the life span of D. melanogaster using adult feeding method. MATERIALS AND METHODS: For experimental setups, the regular food media were mixed with Guduchi Churna in different concentrations (0.25 g/100 ml, 0.50 g/100 ml, and 0.70 g/100 ml). Flies were exposed to these concentrations for 30 days. RESULTS: Increase in the lifespan was observed in both parent and F-1 generation. Applying of ANOVA revealed significant difference between control and drug groups. The longevity effect, in the drug group was seen even on F-1 generation. CONCLUSION: Guduchi Churna enhances the life span of D. melanogaster in both parent and F-1 generation.

Effect of Ekakala Bhojana in patients of Agnimandya.

BACKGROUND: Though Sushruta Samhita is considered as the chief surgical treatise, Maharshi Sushruta has also emphasized on the preventive and curative aspects of diet. Dwadasha Ashana Pravichara is one of the unique concepts of Sushruta Samhita which can be considered as the root of diet therapy. In Dwadasha Ashana Pravichara, diet pattern is described for both healthy and diseased people. AIM: This study aimed to assess the effect of Ekakala Bhojana in Agnimandya patients. MATERIALS AND METHODS: Patients fulfilling the criteria of selection were selected for the present study and were divided into two groups using simple random sampling method. Patients were treated for 10 days. The patients in Group A were treated with Trikatu tablet and those in Group B were given Ekakala Bhojana and placebo tablet. Effect of therapy was assessed on the basis of Abhyavaharana and Jarana Shakti. RESULTS: Group B (Ekakala Bhojana) shows better results than Group A in the parameters of Abhyavaharana and Jarana Shakti except in Udgarashuddhi. Group B (65.19%) shows better result in Ahara shakti than that of Group A (55.76%). CONCLUSION: Agnimadya may be treated at primary level without the use of any medicine and only by reducing frequency of meal to Ekakala Bhojana.

A randomized open-label comparative clinical study of effect of lifestyle modification and Shatapushpadya Churna on Agnimandya.

BACKGROUND: Non-communicable diseases are expected to kill more people in the 21st century which are the resultant of deranged lifestyle such as unhealthy dietary habits and wrong behavioral pattern. In Ayurveda, Ahara Vidhi (dietary rules) and Vihara (conducts) are described in detail which can be included under the heading of lifestyle. Agnimandya (indigestion) is considered as the root cause of all diseases like diabetes mellitus, obesity etc., which are few among the top ten lifestyle disorders. AIM: The present study is aimed at establishment of relationship between disturbances in lifestyle and Agnimandya and role of lifestyle modification in correcting the state of Agnimandya. MATERIALS AND METHODS: The present study was carried out on 33 patients diagnosed with Agnimandya having disturbed lifestyle. Patients were divided into two groups with simple random sampling method. In Group A, lifestyle modification was advised with placebo capsules of wheat flour, while in Group B, patients were treated with 2 g of Shatapushpadya Churna for 2 weeks. RESULTS: Both the groups showed statistically highly significant results on majority of the symptoms of Agnimandya, however, Group A provided better effect than Group B. CONCLUSION: Lifestyle has definite role in the manifestation and treatment of Agnimandya.

Adverse reaction of Parasika Yavani (Hyoscyamus niger Linn): Two case study reports.

Adverse drug reaction (ADR) is an unpleasant reaction related to the use of medicine at its therapeutic dose. Ayurveda is well aware of such adverse reactions. Parasika Yavani (Hyoscyamus niger Linn.) is an Ayurvedic drug effectively used in many psychological disorders, if not used judiciously it causes adverse reactions. In present study two cases of ADR on the usage of Parasika Yavani are reported. Churna in capsule form given in different dosage forms (500 mg once a day, 250 mg twice a day, 250 mg once a day) in Chittodwega (generalised anxiety disorder). 500mg capsule was given to many patients in the study, but no adverse reactions were noticed except in above given two cases. So, in these two cases, the dose was tapered down to 250 mg twice a day, and then to 250 mg once a day to avert the adverse reactions and to fix the therapeutic dose in such individuals (250 mg once a day). On analysis, these two individuals were found to be of Pitta Prakriti. Parasika Yavani is found to increase Pitta and triggers the establishment of ADRs. So, while administering therapeutic dosage, a physician should be vigilant. In the current study, it is observed that 500 mg of Parasika Yavani powder in Pitta Prakriti individuals triggered ADRs while 250 mg once a day was safe. It was also observed that Kapha and Vata Prakriti, patients did not develop any adverse reactions.

A placebo-controlled clinical evaluation of Kharjurapaka in Mamsakshaya.

INTRODUCTION: The world is facing most of the health problems due to nutritional imbalance, and Mamsakshaya (wasting) is one of them. Mamsakshaya explained in Kiyantahshirasiya Adhyaya can be considered as a separate entity, and it can be correlated with Karshya vyadhi. Mamsakshaya occurs due to diminished Prithvi and Jala Mahabhuta in the body and also due to improper diet and environmental factors. Kharjurapaka (KP) is having Prithvi and Jala Mahabhuta dominance and Guru (heavy), Shita (cold), Snigdha (unctuous) Guna (property) which are similar to conjugation of Mamsa Dhatu. AIM: The aim of this study is to evaluate Brimhana (nourishment) effect of KP on having signs and symptoms of Mamsakshaya patients. MATERIALS AND METHODS: The study was therapeutic, interventional, randomized placebo controlled clinical trial carried out on 34 patients of Mamsakshaya. Patients were divided into two Groups. In Group A (trial group), KP (20 g) once in a day with normal water was administered for 30 days, and in Group B (control group), placebo tablet (500 mg) of roasted wheat flour for 30 days duration was administered. Effect of therapy was assessed on subjective and objective parameters, anthropometrical parameters such as body mass index (BMI), weight, and chest circumference. RESULTS: It was found that Group A showed significant results in BMI and sign and symptom of Mamsakshaya in comparison to Group B. CONCLUSION: KP showed better efficacy in comparison with placebo group.

Practical applicability of Nyayas - (Maxims) mentioned in Chakrapani Tika.

The Nyayas - (Maxims) are of two types: (1) Loukika Nyaya and (2) Shastriya Nyaya. Loukika Nyayas are the one which are used by the common public in day today life whereas Shastriya Nyayas are the one which are used by the authors of the treatise to explore their concepts. Most commonly by using the meaning and gist of Loukika Nyaya, the Shastriya Nyayas were put forth by the Granthakaras. Moreover, notion of Nyaya depends upon the situation, place, and topic of explanation mainly. To explain the meaning of the topic, these Nyayas helped since Vaidika Kala. They teach hidden meaning correctly. As like Vedas, these Nyayas are also a part of other Shastras and so as in Ayurveda Shastra too. While explaining the Nidana, Chikitsa, etc., these Nyayas were utilized by the Acharyas of Ayurveda. To discern these Nyayas in their entirety at one place with examples is necessary for easy understanding of the Shastra. Here is an attempt to explore such Nyayas mentioned in Ayurveda for the benefit of easy understanding of the subject.

An observational pilot study on the effect of Gomutra Haritaki, diet control and exercise in the management of Sthaulya (obesity).

BACKGROUND: India is currently witnessing rising numbers of people in the middle-class who are obese. A lot of the Indian population has started relying on processed foods that contain a huge percentage of trans-fat, sugars, and other unhealthy and artificial ingredients. Obesity is considered the core of many diseases. Increased weight carries significant health risks for some cancers, diabetes, heart diseases and strokes. Junk food, alcohol and sedentary lifestyle are leading us to silent self destruction, making one in every five Indian men and women either obese or overweight. AIM: To determine the effect of Gomutra Haritaki on Sthaulya. MATERIALS AND METHODS: An observational pilot study on the effect of Gomutra Haritaki, diet control and exercise in the management of Sthaulya (obesity) was conducted on 21 patients. Enrolled patients were screened on the basis of clinical findings and allocated into two groups. Trial group received Gomutra Haritaki (6 g/day in three divided doses) while control group received placebo capsules in the same dose for 8 weeks. RESULT: Statistically highly significant relief was found in weight reduction (P < 0.001), and body mass index (BMI) (P < 0.01) in both groups. Control group has shown better results against trial group. CONCLUSION: These results prove the impact of diet and exercise in the management of Sthaulya.

Importance of Manas Tattva: A searchlight in Yoga Darshana.

Since time immemorial 'Manas' has been the subject of curiosity for scholars, scientists and philosophers. The reason behind this curiosity is its importance in the development of mankind. Human being is superior to other creatures in the series of development. This supremacy of man remains in his quality to work after thinking, which is the function of 'Manas'. No other animal is capable to think logically. This is the only reason which leads the mankind to the crest of development in every aspect. To highlight the concept of Manas in Yoga Darshana, information extracted from Yoga literatures and Ayurvedic Samhitas. In Indian culture mind has been described from various angles. Vedic, Philosophical and Ayurvedic literatures have a vast and exclusive description of Manas. Philosophers either Astika or Nastika have described Manas Siddhanta vividly. Though many kinds of difference of opinions are there, Yoga Darshana accept the importance of mind in the process of perception and even for the birth of any individual.

Nootropic (medhya) effect of Bhavita Sankhapuspi tablets: A clinical appraisal.

BACKGROUND: Nootropic (medhya) potential of sankhapuspi (Convolvulus pluricaulis Choisy.) is reported in Ayurvedic literature and modern studies are now validating the same. In spite of plentiful preclinical researches already carried out during the past decades, only meager clinical efforts exploring its nootropic activity have been reported. Present clinical study is an attempt to evaluate the nootropic effect of Sankhapuspi tablets. AIMS AND OBJECTIVE: To evaluate the nootropic effect of sankhapuspi tablets prepared by three Bhavana (levigation) of its curna (powder) with its own Svarasa (fresh juice). MATERIALS AND METHODS: Thirty volunteers between the age 16 and 25 years participated in this single group pre-post study. Weschler's memory scale was adopted to collect data before (pre) and after (post) intervention period (2 months). Paired t-test was used for analyzing the data. RESULTS: In auditory immediate test and delayed test, 41.03% and 48% improvement was found which statistically highly significant (<0.001). In visual immediate and delayed test 32.5% and 44.87% improvement was found respectively, which shows highly significant result (<0.001). CONCLUSION: Results reveal that sankhapuspi tablet shown highly significant results in improving memory, especially in long term memory loss in younger age group.

Role of diet and lifestyle in the management of Madhumeha (Diabetes Mellitus).

From ancient to modern times, the perspective to visualize the management of Madhumeha (DM) has shifted from holistic to drug oriented. Therefore, until a few years ago, the revival of the holistic approach, the Ayurvedic diet, and lifestyle were not being much focused. This research work was planned to evaluate the extra effects of Ayurvedic Ahara and Vihara in the management of Madhumeha and to project them socially. A total of 30 patients were selected and divided into two groups. Group A was treated with Ayurvedic Ahara and Vihara with Varadi Kwatha and group B was treated with only Varadi Kwatha for 8 weeks. The study showed highly significant results in most of the parameters in both the groups. However, further trials with increased number of patients are needed to support the current observations.

Evaluation of diet and life style in the etiopathogenesis of Urdhwaga Amlapitta (non-ulcer dyspepsia).

For a long time, infectious (communicable) diseases were the biggest killer diseases globally. But now, the trend is changing toward increased prevalence of chronic diseases with causative factors mostly related to diet and lifestyle. Among them, Urdhwaga Amlapitta (non-ulcer dyspepsia), a gastrointestinal tract (GIT) disorder, has acquired majority of the share with causative factors like improper diet and habits, stress, spicy irritant food, oily foods, bakery products, etc., A survey study was conducted on 138 patients, irrespective of sex, religion, etc., who had presented with the clinical symptoms of Urdhwaga Amlapitta and attended the OPD of Department of Basic Principles, at I.P.G.T. and R.A., Gujarat Ayurved University, Jamnagar, between February 2009 and June 2010. Information on demography, dietary intake, and lifestyle factors was collected by standard questionnaires. The data revealed that majority of the patients indulged in faulty dietary habits like excess Katu Ahara Sevana (99.3%), Amla Ahara (95.65%), Guru Ahara (90.57%), Snigdha Ahara (86.23%), Viruddha (81.88%), Abhishyandi Ahara (81.88%), Atiushna Ahara (73.9%), Vidahi (51.44%), Pistanna (47.10%), etc., and the data on lifestyle revealed that majority of the patients indulged in Diwasvapna (89.85%), Antarodaka Paanam (81.88%), Chinta (79.71%), etc., This survey study upholds the novel concept of diet and lifestyle of Ayurveda. The data reflects that dietary patterns, lifestyle choices, and physical activities play an important role in the etiopathogenesis of Urdhwaga Amlapitta, and it is important for patients to have access to diet and lifestyle modifications. Currently, research in this area is minimal.

Critical review on Bhaishajya Kaala (time of drug administration) in Ayurveda.

Bhaishajya Kaala (time of drug administration) is an important principle to be considered while treating a disease. Still hardly a handful of physicians are seen, who account for this. To highlight its imperial role in Chikitsa, there is an immense necessity to analyze this concept, which is the need of the hour. Bhaishajya Kaala is mainly explained in relation with Bala of Roga, Rogi, particular Dosha, Dooshya, and various other factors. The comprehensive understanding of this concept involves so many questions as, why there is a difference in the number of Aushdha Kaala? What is the logic behind their indications as well as contraindications? The present paper focuses on the above points to find out the convincing answers.