Detalhe da pesquisa
1.
Small molecules targeting hepatitis C virus-encoded NS5A cause subcellular redistribution of their target: insights into compound modes of action.
J Virol
; 85(13): 6353-68, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21507963
2.
Palladium-catalyzed synthesis of benzimidazoles and quinazolinones from common precursors.
J Org Chem
; 77(21): 9473-86, 2012 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-23030827
3.
Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reducing ion channel activity.
Bioorg Med Chem Lett
; 20(12): 3788-92, 2010 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20471260
4.
Design, synthesis and evaluation of N-[(3S)-pyrrolidin-3-yl]benzamides as selective noradrenaline reuptake inhibitors: CNS penetration in a more polar template.
Bioorg Med Chem Lett
; 19(16): 4579-83, 2009 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19616432
5.
4-Piperidines and 3-pyrrolidines as dual serotonin and noradrenaline reuptake inhibitors: design, synthesis and structure-activity relationships.
Bioorg Med Chem Lett
; 19(10): 2829-34, 2009 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19359175
6.
N-[(3S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: impact of small structural modifications on P-gp recognition and CNS penetration.
Bioorg Med Chem Lett
; 19(17): 5078-81, 2009 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19647430
7.
[4-(Phenoxy)pyridin-3-yl]methylamines: a new class of selective noradrenaline reuptake inhibitors.
Bioorg Med Chem Lett
; 18(6): 1795-8, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18313294
8.
Pyridyl-phenyl ether monoamine reuptake inhibitors: Impact of lipophilicity on dual SNRI pharmacology and off-target promiscuity.
Bioorg Med Chem Lett
; 18(9): 2896-9, 2008 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18417343
9.
N-Benzyl-N-(pyrrolidin-3-yl)carboxamides as a new class of selective dual serotonin/noradrenaline reuptake inhibitors.
Bioorg Med Chem Lett
; 18(15): 4308-11, 2008 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18625557
10.
Derivatives of (3S)-N-(biphenyl-2-ylmethyl)pyrrolidin-3-amine as selective noradrenaline reuptake inhibitors: Reducing P-gp mediated efflux by modulation of H-bond acceptor capacity.
Bioorg Med Chem Lett
; 18(15): 4355-9, 2008 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18621528
11.
Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition.
Bioorg Med Chem Lett
; 18(8): 2562-6, 2008 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18387300
12.
Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.
J Med Chem
; 60(2): 767-786, 2017 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27983835
13.
Cytoprotection by omega-3 fatty acids as a therapeutic drug vehicle when combined with nephrotoxic drugs in an intravenous emulsion: Effects on intraglomerular mesangial cells.
Toxicol Rep
; 1: 843-857, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-28962296
14.
The discovery of potent nonstructural protein 5A (NS5A) inhibitors with a unique resistance profile-Partâ 1.
ChemMedChem
; 9(7): 1378-86, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24729513
15.
The discovery of potent nonstructural protein 5A (NS5A) inhibitors with a unique resistance profile-Partâ 2.
ChemMedChem
; 9(7): 1387-96, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24729518
16.
In-cell click labelling of small molecules to determine subcellular localisation.
J Chem Biol
; 4(2): 49-53, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22096474
17.
Understanding CYP2D6 interactions.
Drug Discov Today
; 14(19-20): 964-72, 2009 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-19638317
18.
N-Benzyl-N-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-amines as selective dual serotonin/noradrenaline reuptake inhibitors.
Bioorg Med Chem Lett
; 17(7): 2022-5, 2007 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17267217
19.
Structure-activity relationships of N-substituted piperazine amine reuptake inhibitors.
Bioorg Med Chem Lett
; 16(16): 4349-53, 2006 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16750363
20.
N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor.
Bioorg Med Chem Lett
; 16(16): 4345-8, 2006 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16750359