Detalhe da pesquisa
1.
Non-canonical endogenous expression of voltage-gated sodium channel NaV 1.7 subtype by the TE671 rhabdomyosarcoma cell line.
J Physiol
; 600(10): 2499-2513, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35413129
2.
Identification of a Proteasome-Targeting Arylsulfonamide with Potential for the Treatment of Chagas' Disease.
Antimicrob Agents Chemother
; 66(1): e0153521, 2022 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34606338
3.
Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.
Proc Natl Acad Sci U S A
; 116(19): 9318-9323, 2019 05 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30962368
4.
Clinical and veterinary trypanocidal benzoxaboroles target CPSF3.
Proc Natl Acad Sci U S A
; 115(38): 9616-9621, 2018 09 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30185555
5.
Systematic analysis of Plasmodium myosins reveals differential expression, localisation, and function in invasive and proliferative parasite stages.
Cell Microbiol
; 21(10): e13082, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31283102
6.
Compositional and expression analyses of the glideosome during the Plasmodium life cycle reveal an additional myosin light chain required for maximum motility.
J Biol Chem
; 292(43): 17857-17875, 2017 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28893907
7.
Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals.
Antimicrob Agents Chemother
; 62(8)2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29844044
8.
The Role of Folate Transport in Antifolate Drug Action in Trypanosoma brucei.
J Biol Chem
; 291(47): 24768-24778, 2016 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-27703008
9.
Plasmodium P-Type Cyclin CYC3 Modulates Endomitotic Growth during Oocyst Development in Mosquitoes.
PLoS Pathog
; 11(11): e1005273, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26565797
10.
Seismic and experimental insights into eruption precursors at Volcán de Colima.
Geophys Res Lett
; 44(12): 6092-6100, 2017 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30166740
11.
The Plasmodium Class XIV Myosin, MyoB, Has a Distinct Subcellular Location in Invasive and Motile Stages of the Malaria Parasite and an Unusual Light Chain.
J Biol Chem
; 290(19): 12147-64, 2015 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25802338
12.
RES-Seq-a barcoded library of drug-resistant Leishmania donovani allowing rapid assessment of cross-resistance and relative fitness.
mBio
; : e0180323, 2023 Nov 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37929970
13.
Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of Analogues.
J Med Chem
; 66(13): 8896-8916, 2023 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37343180
14.
Short-course combination treatment for experimental chronic Chagas disease.
Sci Transl Med
; 15(726): eadg8105, 2023 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38091410
15.
DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc1.
Sci Transl Med
; 15(726): eadh9902, 2023 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38091406
16.
Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase.
ACS Infect Dis
; 8(9): 1962-1974, 2022 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36037410
17.
Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis.
J Med Chem
; 65(7): 5606-5624, 2022 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35303411
18.
Identification of Resistance Determinants for a Promising Antileishmanial Oxaborole Series.
Microorganisms
; 9(7)2021 Jun 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-34210040
19.
Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial.
Cell Chem Biol
; 28(5): 711-721.e8, 2021 05 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-33691122
20.
DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis.
J Med Chem
; 64(21): 16159-16176, 2021 11 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34711050