Pesquisa | Portal de Pesquisa da BVS

1.

Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes.

Ganz, Javier; Luquette, Lovelace J; Bizzotto, Sara; Miller, Michael B; Zhou, Zinan; Bohrson, Craig L; Jin, Hu; Tran, Antuan V; Viswanadham, Vinayak V; McDonough, Gannon; Brown, Katherine; Chahine, Yasmine; Chhouk, Brian; Galor, Alon; Park, Peter J; Walsh, Christopher A.

Cell ; 187(8): 1955-1970.e23, 2024 Apr 11.

Artigo em Inglês | MEDLINE | ID: mdl-38503282

2.

Propofol: Milk of Amnesia.

Walsh, Christopher T.

Cell ; 175(1): 10-13, 2018 09 20.

Artigo em Inglês | MEDLINE | ID: mdl-30217361

3.

At the Intersection of Chemistry, Biology, and Medicine.

Walsh, Christopher T.

Annu Rev Biochem ; 86: 1-19, 2017 06 20.

Artigo em Inglês | MEDLINE | ID: mdl-28125288

4.

Propofol: Milk of Amnesia.

Walsh, Christopher T.

Cell ; 185(25): 4861, 2022 Dec 08.

Artigo em Inglês | MEDLINE | ID: mdl-36493757

5.

Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex.

Zhang, Xiaochang; Chen, Ming Hui; Wu, Xuebing; Kodani, Andrew; Fan, Jean; Doan, Ryan; Ozawa, Manabu; Ma, Jacqueline; Yoshida, Nobuaki; Reiter, Jeremy F; Black, Douglas L; Kharchenko, Peter V; Sharp, Phillip A; Walsh, Christopher A.

Cell ; 166(5): 1147-1162.e15, 2016 Aug 25.

Artigo em Inglês | MEDLINE | ID: mdl-27565344

6.

Mutations in Human Accelerated Regions Disrupt Cognition and Social Behavior.

Doan, Ryan N; Bae, Byoung-Il; Cubelos, Beatriz; Chang, Cindy; Hossain, Amer A; Al-Saad, Samira; Mukaddes, Nahit M; Oner, Ozgur; Al-Saffar, Muna; Balkhy, Soher; Gascon, Generoso G; Nieto, Marta; Walsh, Christopher A.

Cell ; 167(2): 341-354.e12, 2016 Oct 06.

Artigo em Inglês | MEDLINE | ID: mdl-27667684

7.

Somatic genomic changes in single Alzheimer's disease neurons.

Miller, Michael B; Huang, August Yue; Kim, Junho; Zhou, Zinan; Kirkham, Samantha L; Maury, Eduardo A; Ziegenfuss, Jennifer S; Reed, Hannah C; Neil, Jennifer E; Rento, Lariza; Ryu, Steven C; Ma, Chanthia C; Luquette, Lovelace J; Ames, Heather M; Oakley, Derek H; Frosch, Matthew P; Hyman, Bradley T; Lodato, Michael A; Lee, Eunjung Alice; Walsh, Christopher A.

Nature ; 604(7907): 714-722, 2022 04.

Artigo em Inglês | MEDLINE | ID: mdl-35444284

8.

Exome copy number variant detection, analysis, and classification in a large cohort of families with undiagnosed rare genetic disease.

Lemire, Gabrielle; Sanchis-Juan, Alba; Russell, Kathryn; Baxter, Samantha; Chao, Katherine R; Singer-Berk, Moriel; Groopman, Emily; Wong, Isaac; England, Eleina; Goodrich, Julia; Pais, Lynn; Austin-Tse, Christina; DiTroia, Stephanie; O'Heir, Emily; Ganesh, Vijay S; Wojcik, Monica H; Evangelista, Emily; Snow, Hana; Osei-Owusu, Ikeoluwa; Fu, Jack; Singh, Mugdha; Mostovoy, Yulia; Huang, Steve; Garimella, Kiran; Kirkham, Samantha L; Neil, Jennifer E; Shao, Diane D; Walsh, Christopher A; Argilli, Emanuela; Le, Carolyn; Sherr, Elliott H; Gleeson, Joseph G; Shril, Shirlee; Schneider, Ronen; Hildebrandt, Friedhelm; Sankaran, Vijay G; Madden, Jill A; Genetti, Casie A; Beggs, Alan H; Agrawal, Pankaj B; Bujakowska, Kinga M; Place, Emily; Pierce, Eric A; Donkervoort, Sandra; Bönnemann, Carsten G; Gallacher, Lyndon; Stark, Zornitza; Tan, Tiong Yang; White, Susan M; Töpf, Ana.

Am J Hum Genet ; 111(5): 863-876, 2024 May 02.

Artigo em Inglês | MEDLINE | ID: mdl-38565148

9.

Genetic mosaicism in the human brain: from lineage tracing to neuropsychiatric disorders.

Bizzotto, Sara; Walsh, Christopher A.

Nat Rev Neurosci ; 23(5): 275-286, 2022 05.

Artigo em Inglês | MEDLINE | ID: mdl-35322263

10.

Single-neuron sequencing analysis of L1 retrotransposition and somatic mutation in the human brain.

Evrony, Gilad D; Cai, Xuyu; Lee, Eunjung; Hills, L Benjamin; Elhosary, Princess C; Lehmann, Hillel S; Parker, J J; Atabay, Kutay D; Gilmore, Edward C; Poduri, Annapurna; Park, Peter J; Walsh, Christopher A.

Cell ; 151(3): 483-96, 2012 Oct 26.

Artigo em Inglês | MEDLINE | ID: mdl-23101622

11.

Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation.

Yang, Yawei J; Baltus, Andrew E; Mathew, Rebecca S; Murphy, Elisabeth A; Evrony, Gilad D; Gonzalez, Dilenny M; Wang, Estee P; Marshall-Walker, Christine A; Barry, Brenda J; Murn, Jernej; Tatarakis, Antonis; Mahajan, Muktar A; Samuels, Herbert H; Shi, Yang; Golden, Jeffrey A; Mahajnah, Muhammad; Shenhav, Ruthie; Walsh, Christopher A.

Cell ; 151(5): 1097-112, 2012 Nov 21.

Artigo em Inglês | MEDLINE | ID: mdl-23178126

12.

Bi-allelic variants in INTS11 are associated with a complex neurological disorder.

Tepe, Burak; Macke, Erica L; Niceta, Marcello; Weisz Hubshman, Monika; Kanca, Oguz; Schultz-Rogers, Laura; Zarate, Yuri A; Schaefer, G Bradley; Granadillo De Luque, Jorge Luis; Wegner, Daniel J; Cogne, Benjamin; Gilbert-Dussardier, Brigitte; Le Guillou, Xavier; Wagner, Eric J; Pais, Lynn S; Neil, Jennifer E; Mochida, Ganeshwaran H; Walsh, Christopher A; Magal, Nurit; Drasinover, Valerie; Shohat, Mordechai; Schwab, Tanya; Schmitz, Chris; Clark, Karl; Fine, Anthony; Lanpher, Brendan; Gavrilova, Ralitza; Blanc, Pierre; Burglen, Lydie; Afenjar, Alexandra; Steel, Dora; Kurian, Manju A; Prabhakar, Prab; Gößwein, Sophie; Di Donato, Nataliya; Bertini, Enrico S; Wangler, Michael F; Yamamoto, Shinya; Tartaglia, Marco; Klee, Eric W; Bellen, Hugo J.

Am J Hum Genet ; 110(5): 774-789, 2023 05 04.

Artigo em Inglês | MEDLINE | ID: mdl-37054711

13.

Evolutionary Changes in Transcriptional Regulation: Insights into Human Behavior and Neurological Conditions.

Doan, Ryan N; Shin, Taehwan; Walsh, Christopher A.

Annu Rev Neurosci ; 41: 185-206, 2018 07 08.

Artigo em Inglês | MEDLINE | ID: mdl-29986162

14.

Innovations present in the primate interneuron repertoire.

Krienen, Fenna M; Goldman, Melissa; Zhang, Qiangge; C H Del Rosario, Ricardo; Florio, Marta; Machold, Robert; Saunders, Arpiar; Levandowski, Kirsten; Zaniewski, Heather; Schuman, Benjamin; Wu, Carolyn; Lutservitz, Alyssa; Mullally, Christopher D; Reed, Nora; Bien, Elizabeth; Bortolin, Laura; Fernandez-Otero, Marian; Lin, Jessica D; Wysoker, Alec; Nemesh, James; Kulp, David; Burns, Monika; Tkachev, Victor; Smith, Richard; Walsh, Christopher A; Dimidschstein, Jordane; Rudy, Bernardo; S Kean, Leslie; Berretta, Sabina; Fishell, Gord; Feng, Guoping; McCarroll, Steven A.

Nature ; 586(7828): 262-269, 2020 10.

Artigo em Inglês | MEDLINE | ID: mdl-32999462

15.

Author Correction: Innovations present in the primate interneuron repertoire.

Krienen, Fenna M; Goldman, Melissa; Zhang, Qiangge; Del Rosario, Ricardo C H; Florio, Marta; Machold, Robert; Saunders, Arpiar; Levandowski, Kirsten; Zaniewski, Heather; Schuman, Benjamin; Wu, Carolyn; Lutservitz, Alyssa; Mullally, Christopher D; Reed, Nora; Bien, Elizabeth; Bortolin, Laura; Fernandez-Otero, Marian; Lin, Jessica D; Wysoker, Alec; Nemesh, James; Kulp, David; Burns, Monika; Tkachev, Victor; Smith, Richard; Walsh, Christopher A; Dimidschstein, Jordane; Rudy, Bernardo; Kean, Leslie S; Berretta, Sabina; Fishell, Gord; Feng, Guoping; McCarroll, Steven A.

Nature ; 588(7837): E17, 2020 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-33230336

16.

Glial dysregulation in the human brain in fragile X-associated tremor/ataxia syndrome.

Dias, Caroline M; Issac, Biju; Sun, Liang; Lukowicz, Abigail; Talukdar, Maya; Akula, Shyam K; Miller, Michael B; Walsh, Katherine; Rockowitz, Shira; Walsh, Christopher A.

Proc Natl Acad Sci U S A ; 120(23): e2300052120, 2023 06 06.

Artigo em Inglês | MEDLINE | ID: mdl-37252957

17.

TMEM161B regulates cerebral cortical gyration, Sonic Hedgehog signaling, and ciliary structure in the developing central nervous system.

Akula, Shyam K; Marciano, Jack H; Lim, Youngshin; Exposito-Alonso, David; Hylton, Norma K; Hwang, Grace H; Neil, Jennifer E; Dominado, Nicole; Bunton-Stasyshyn, Rosie K; Song, Janet H T; Talukdar, Maya; Schmid, Aloisia; Teboul, Lydia; Mo, Alisa; Shin, Taehwan; Finander, Benjamin; Beck, Samantha G; Yeh, Rebecca C; Otani, Aoi; Qian, Xuyu; DeGennaro, Ellen M; Alkuraya, Fowzan S; Maddirevula, Sateesh; Cascino, Gregory D; Giannini, Caterina; Burrage, Lindsay C; Rosenfield, Jill A; Ketkar, Shamika; Clark, Gary D; Bacino, Carlos; Lewis, Richard A; Segal, Rosalind A; Bazan, J Fernando; Smith, Kelly A; Golden, Jeffrey A; Cho, Ginam; Walsh, Christopher A.

Proc Natl Acad Sci U S A ; 120(4): e2209964120, 2023 Jan 24.

Artigo em Inglês | MEDLINE | ID: mdl-36669111

18.

Impaired catabolism of free oligosaccharides due to MAN2C1 variants causes a neurodevelopmental disorder.

Maia, Nuno; Potelle, Sven; Yildirim, Hamide; Duvet, Sandrine; Akula, Shyam K; Schulz, Celine; Wiame, Elsa; Gheldof, Alexander; O'Kane, Katherine; Lai, Abbe; Sermon, Karen; Proisy, Maïa; Loget, Philippe; Attié-Bitach, Tania; Quelin, Chloé; Fortuna, Ana Maria; Soares, Ana Rita; de Brouwer, Arjan P M; Van Schaftingen, Emile; Nassogne, Marie-Cécile; Walsh, Christopher A; Stouffs, Katrien; Jorge, Paula; Jansen, Anna C; Foulquier, François.

Am J Hum Genet ; 109(2): 345-360, 2022 02 03.

Artigo em Inglês | MEDLINE | ID: mdl-35045343

19.

Neurogenesis at the brain-cerebrospinal fluid interface.

Lehtinen, Maria K; Walsh, Christopher A.

Annu Rev Cell Dev Biol ; 27: 653-79, 2011.

Artigo em Inglês | MEDLINE | ID: mdl-21801012

20.

Brain Somatic Mutation in Aging and Alzheimer's Disease.

Miller, Michael B; Reed, Hannah C; Walsh, Christopher A.

Annu Rev Genomics Hum Genet ; 22: 239-256, 2021 08 31.

Artigo em Inglês | MEDLINE | ID: mdl-33979534

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Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes.

Propofol: Milk of Amnesia.

At the Intersection of Chemistry, Biology, and Medicine.

Propofol: Milk of Amnesia.

Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex.

Mutations in Human Accelerated Regions Disrupt Cognition and Social Behavior.

Somatic genomic changes in single Alzheimer's disease neurons.

Exome copy number variant detection, analysis, and classification in a large cohort of families with undiagnosed rare genetic disease.

Genetic mosaicism in the human brain: from lineage tracing to neuropsychiatric disorders.

Single-neuron sequencing analysis of L1 retrotransposition and somatic mutation in the human brain.

Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation.

Bi-allelic variants in INTS11 are associated with a complex neurological disorder.

Evolutionary Changes in Transcriptional Regulation: Insights into Human Behavior and Neurological Conditions.

Innovations present in the primate interneuron repertoire.

Author Correction: Innovations present in the primate interneuron repertoire.

Glial dysregulation in the human brain in fragile X-associated tremor/ataxia syndrome.

TMEM161B regulates cerebral cortical gyration, Sonic Hedgehog signaling, and ciliary structure in the developing central nervous system.

Impaired catabolism of free oligosaccharides due to MAN2C1 variants causes a neurodevelopmental disorder.

Neurogenesis at the brain-cerebrospinal fluid interface.

Brain Somatic Mutation in Aging and Alzheimer's Disease.