RESUMO
Bladder cancer is a common malignant urinary tumor, and patients with bladder cancer have poor prognosis. Abnormal lipid metabolism in peroxisomes is involved in tumor progression. Hydroxysteroid dehydrogenase-like 2 (HSDL2) localized in peroxisomes regulates fatty acid synthesis. In the present study, we reported that HSDL2 was upregulated in two human bladder cancer cell lines 5637 and T24 compared to normal human urothelial cells. Furthermore, lentiviral-mediated HSDL2 knockdown inhibited the proliferation and colony formation while promoted the apoptosis of human bladder cancer T24 cells in vitro. In nude mice HSDL2 knockdown inhibited the growth of T24 derived xenografts in vivo. In conclusion, our results suggest that HSDL2 plays an oncogenic role in bladder cancer and might serve as a potential target for bladder cancer therapy.
Assuntos
Hidroxiesteroide Desidrogenases/metabolismo , Oncogenes , Neoplasias da Bexiga Urinária/patologia , Animais , Apoptose , Linhagem Celular Tumoral , Proliferação de Células , Feminino , Regulação Neoplásica da Expressão Gênica , Técnicas de Silenciamento de Genes , Humanos , Hidroxiesteroide Desidrogenases/genética , Camundongos , Camundongos Nus , RNA Interferente Pequeno/metabolismo , Regulação para Cima , Bexiga Urinária/citologia , Bexiga Urinária/patologia , Neoplasias da Bexiga Urinária/genética , Urotélio/citologia , Urotélio/patologia , Ensaios Antitumorais Modelo de XenoenxertoRESUMO
The title compound, [Cu(2)Fe(3)(C(5)H(5))(3)(C(2)H(3)O(2))(C(6)H(4)O(2))(3)(C(3)H(7)NO)(2)], belongs to the classic dimeric paddle-wheel structure type. It is an unusual example in that it contains two different carboxylate groups, viz. ferrocenecarboxylate and acetate. With three ferrocenecarboxylate groups and only one acetate group bridging the two Cu centres, a noncentrosymmetric molecular arrangement results.