Light chaotic dynamics in the transformation from curved to flat surfaces.

Light propagation on a two-dimensional curved surface embedded in a three-dimensional space has attracted increasing attention as an analog model of four-dimensional curved spacetime in the laboratory. Despite recent developments in modern cosmology on the dynamics and evolution of the universe, investigation of nonlinear dynamics of light on non-Euclidean geometry is still scarce, with fundamental questions, such as the effect of curvature on deterministic chaos, challenging to address. Here, we study classical and wave chaotic dynamics on a family of surfaces of revolution by considering its equivalent conformally transformed flat billiard, with nonuniform distribution of the refractive index. We prove rigorously that these two systems share the same dynamics. By exploring the Poincaré surface of section, the Lyapunov exponent, and the statistics of eigenmodes and eigenfrequency spectrum in the transformed inhomogeneous table billiard, we find that the degree of chaos is fully controlled by a single, curvature-related geometric parameter of the curved surface. A simple interpretation of our findings in transformed billiards, the "fictitious force," allows us to extend our prediction to other classes of curved surfaces. This powerful analogy between two a priori unrelated systems not only brings forward an approach to control the degree of chaos, but also provides potentialities for further studies and applications in various fields, such as billiards design, optical fibers, or laser microcavities.

Optimizing focus: switchable modes and sub-diffraction spots in inverse circular Airy beams.

We report an experimental investigation into the tight-focusing characteristics of linearly polarized inverse circular Airy beams (ICABs). Our study reveals that tightly focused ICABs exhibit Bessel-like, needle-like, or dual foci profiles depending on whether the main ring's radius is smaller than, equal to, or larger than the critical radius. The emergence of the dual foci structure is attributed to the constrained entrance aperture of the microscope objective (MO). In contrast to traditional Gaussian beams (GBs), ICABs demonstrate remarkable advantages in terms of focal spot size. Notably, we observe a focal spot with a size of 245 nm, representing a 26.4% reduction compared to the diffraction limit. These unique properties open up promising avenues for potential applications in optical multi-plane particle trapping, conveying, and super-resolution optical imaging.

Meta-Analysis on the Therapeutic Effect of Transcatheter Arterial Chemoembolization Combined with Portal Vein Embolization.

INTRODUCTION: The aim of the study was to conduct a systematic review to explore the therapeutic effect of transcatheter arterial chemoembolization (TACE) combined with portal vein embolization (PVE) for patients with hepatocellular carcinoma (HCC). METHODS: Chinese and English databases (PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure, Wanfang database, and VIP database) were searched from database inception to August 15, 2023. Studies comparing TACE combined with PVE versus TACE alone for patients with HCC were included. The degree of heterogeneity was assessed using I2 statistics and a Q test. The effect size was represented by risk ratio and mean difference (MD), and the effect size range was estimated using a 95% confidence interval (CI). RESULTS: Eight eligible studies were included in the systematic review, involving 689 participants. The results showed that the future liver residual (FLR) of patients treated with TACE combined with PVE was significantly higher than that of those treated with PVE alone (MD = 3.99%; 95% CI: 1.03-6.94). Furthermore, compared with PVE alone, TACE combined with PVE had a positive effect on disease-free survival (odds ratio [OR] = 2.16; 95% CI: 1.20-3.88), recurrence rate (OR = 0.79; 95% CI: 0.07-9.42), and complications (OR = 0.53; 95% CI: 0.30-0.96). There was no statistically significant impact on mortality with TACE combined with PVE treatment. CONCLUSION: The combination of TACE with PVE can significantly reduce the FLR of patients with HCC, with higher disease-free survival, lower recurrence rate, and fewer complications.

Genetic Architecture Underlying Nascent Speciation-The Evolution of Eurasian Pigs under Domestication.

Speciation is a process whereby the evolution of reproductive barriers leads to isolated species. Although many studies have addressed large-effect genetic footprints in the advanced stages of speciation, the genetics of reproductive isolation in nascent stage of speciation remains unclear. Here, we show that pig domestication offers an interesting model for studying the early stages of speciation in great details. Pig breeds have not evolved the large X-effect of hybrid incompatibility commonly observed between "good species." Instead, deleterious epistatic interactions among multiple autosomal loci are common. These weak Dobzhansky-Muller incompatibilities confer partial hybrid inviability with sex biases in crosses between European and East Asian domestic pigs. The genomic incompatibility is enriched in pathways for angiogenesis, androgen receptor signaling and immunity, with an observation of many highly differentiated cis-regulatory variants. Our study suggests that partial hybrid inviability caused by pervasive but weak interactions among autosomal loci may be a hallmark of nascent speciation in mammals.

Influence of spatial dispersion on phase and lateral shifts near the reflection dip in the Kretschmann-Raether structure.

The influence of spatial dispersion of metals on phase and Goos-Hänchen (GH) shifts near the reflection dip has been investigated in the Kretschmann-Raether configuration, within the hydrodynamic model framework. We have derived an analytical expression of the reflection coefficient and discussed the optical properties when the nonlocality of metals based on the phenomenological model and Kretchmann's theory is taken into account. Our results show that nonlocality has a significant impact for large wavevectors and causes a shift of the critical point corresponding to the total absorption. Furthermore, these changes also lead to diverse changes in the optical properties including amplitude, phase and GH shift close to the conditions of excitation for the surface plasmon. Our work provides a solid foundation for the understanding of nonlocality in multilayered plasmonic structures and paves the way for future experiments.

Experimental observation and manipulation of optical tornado waves.

We report experimental realization and manipulation of optical tornado waves (ToWs). By controlling the self-focusing length, total angular momentum, and foci deviation of ToWs, the propagation properties of optical ToWs, especially their angular velocity, can be manipulated. Controlling the accumulated rotation angle of the main intensity lobes of ToWs from 0° through 1100° is experimentally demonstrated, and their angular velocity is predicted to be the highest around the foci overlap situation. Our experimental results are in good agreement with numerical results.

LINC00536 promotes hepatocellular carcinoma progression via the miR-203b-5p/VEGFA axis.

LncRNAs exert comprehensive effects in regulating the initiation and deterioration of hepatocellular carcinoma (HCC). However, the specific expression profiles and functional mechanisms of LINC00536 in HCC need to be disclosed. The study is intended to clarify the leverage of LINC00536 in HCC and investigate the potential mechanisms for the regulatory role of LINC00536 in the progression of HCC. In our study, LINC00536 was overexpressed in tumor samples of HCC patients and was related to poor prognosis. LINC00536 knockdown impaired cell viability, proliferation, migration, and invasion. LINC00536 can directly bind with miR-203b-5p, trimming the miR-203b-5p expression levels. VEGFA designates as a target of miR-203b-5p. Rescue research indicated that the miR-203b-5p inhibition or VEGFA overexpression could reverse the impaired cell phenotypes induced by LINC00536 knockdown. The in vivo experiments upheld the LINC00536/miR-203b-5p/VEGFA axis in HCC. Conclusively, LINC00536 could promote HCC deterioration via tuning the miR-203b-5p/VEGFA axis. This research may provide theoretical evidence for LINC00536 to get a gratifying therapeutic target for HCC.

Hanbury Brown and Twiss effect in spatiotemporal domain.

Hanbury Brown and Twiss (HBT) effect has broad applications in optics and other branches of physics, and traditionally this effect is considered in pure spatial or temporal domain. Here we investigate the spatiotemporal HBT effect, extending this phenomenon from spatial or temporal to spatiotemporal domain. By assuming the Gaussian statistics of partially coherent spatiotemporal pulsed sources, we find the generalized analytical results for spatiotemporal HBT effect in the compact form, with the help of the matrix-optics method, which can consider the HBT effect in spatial and temporal domain simultaneously. Furthermore, for Gaussian Schell-model pulsed beams (GSMPBs) used as a spatiotemporal correlated source, we have obtained the generalized expression to calculate spatiotemporal HBT effect, which is useful for up to three-dimensional cases in any second-order linear dispersive medium. By taking a simple two-dimensional case and using air as an example of a linear dispersive medium, we numerically illustrate the properties of the spatiotemporal HBT effect by adjusting the spatial and temporal parameters of the GSMPB source, and reveal the influence of both the spatial and temporal parameters on the spatiotemporal HBT effect. This work paves the path towards the detailed study of HBT effect for a source containing spatiotemporal information with Gaussian statistics.

Self-healing property of focused circular Airy beams.

We investigate the self-healing property of focused circular Airy beams (FCAB), and this property is associated with the transverse Poynting vector (energy flow) for a better interpretation. We both experimentally and numerically show the effect of the obstruction's position, size and shape on the self-healing property of FCAB. It is found that FCAB will heal if the obstruction is placed at the area between the two foci of FCAB, and it has the least influence on the FCAB when the obstruction is placed near the lens' rear focal plane, whereas FCAB cannot heal if the obstruction is out of the area between two foci. Our experimental results are in good agreement with numerical results.

P68 RNA helicase promotes invasion of glioma cells through negatively regulating DUSP5.

Gliomas are the most common central nervous system tumors. They show malignant characteristics indicating rapid proliferation and a high invasive capacity and are associated with a poor prognosis. In our previous study, p68 was overexpressed in glioma cells and correlated with both the degree of glioma differentiation and poor overall survival. Downregulating p68 significantly suppressed proliferation in glioma cells. Moreover, we found that the p68 gene promoted glioma cell growth by activating the nuclear factor-κB signaling pathway by a downstream molecular mechanism that remains incompletely understood. In this study, we found that dual specificity phosphatase 5 (DUSP5) is a downstream target of p68, using microarray analysis, and that p68 negatively regulates DUSP5. Upregulating DUSP5 in stably expressing cell lines (U87 and LN-229) suppressed proliferation, invasion, and migration in glioma cells in vitro, consistent with the downregulation of p68. Furthermore, upregulating DUSP5 inhibited ERK phosphorylation, whereas downregulating DUSP5 rescued the level of ERK phosphorylation, indicating that DUSP5 might negatively regulate ERK signaling. Additionally, we show that DUSP5 levels were lower in high-grade glioma than in low-grade glioma. These results suggest that the p68-induced negative regulation of DUSP5 promoted invasion by glioma cells and mediated the activation of the ERK signaling pathway.

Vortex strength and beam propagation factor of fractional vortex beams.

Fractional vortex beams (FVBs) with non-integer topological charges attract much attention due to unique features of propagations, but different viewpoints still exist on the change of their total vortex strength. Here we have experimentally demonstrated the distribution and number of vortices contained in FVBs at the Fraunhofer diffraction region. We have verified that the jumps of total vortex strength for FVBs happen only when non-integer topological charge is before and after (but very close to) any even integer number that originates from two different mechanisms for generation and movement of vortices on focal plane. Meanwhile, we have also measured the beam propagation factor (BPF) of such FVBs and have found that their BPF values almost increase linearly in the x component (along the initial edge dislocation) and oscillate increasingly in the y component (vertical to the initial edge dislocation). Our experimental results are in good agreement with numerical results.

Generalization of Wolf effect of light on arbitrary two-dimensional surface of revolution.

Investigation of physics on two-dimensional curved surface has significant meaning in study of general relativity, inasmuch as its realizability in experimental analogy and verification of faint gravitational effects in laboratory. Several phenomena about dynamics of particles and electromagnetic waves have been explored on curved surfaces. Here we consider Wolf effect, a phenomenon of spectral shift due to the fluctuating nature of light fields, on an arbitrary surface of revolution (SOR). The general expression of the propagation of partially coherent beams propagating on arbitrary SOR is derived and the corresponding evolution of light spectrum is also obtained. We investigate the extra influence of surface topology on spectral shift by defining two quantities, effective propagation distance and effective transverse distance, and compare them with longitudinal and transverse proper lengths. Spectral shift is accelerated when the defined effective quantities are greater than real proper lengths, and vice versa. We also employ some typical SORs, cylindrical surfaces, conical surfaces, SORs generated by power function and periodic peanut-shell shapes, as examples to provide concrete analyses. This work generalizes the research of Wolf effect to arbitrary SORs, and provides a universal method for analyzing properties of propagation compared with that in flat space for any SOR whose topology is known.

Parabolic-Gaussian Schell-model sources and their propagations.

In this work, a new class of partially coherent Schell-type sources is introduced by modifying its degree of coherence, which is a product of a parabolic function and a Gaussian function. Such sources are confirmed to be physically genuine and may be called parabolic-Gaussian Schell-model (PGSM) sources. The propagating expression of the cross-spectral density function of such PGSM sources is derived in a general linear optical system. In particular, the propagation properties of such PGSM beams in both free space and lens systems are discussed. The results show that such PGSM sources can produce dark-hollow intensity profiles in the regions of free space very near as well as far away from the source plane, or in the focal region of the lens system.

Genome-wide study refines the quantitative trait locus for number of ribs in a Large White × Minzhu intercross pig population and reveals a new candidate gene.

In China, sparerib is one of the most valuable parts of the pork carcass. As a result, candidate gene mining for number of ribs has become an interesting study focus. To examine the genetic basis for this major trait, we genotyped 596 individuals from an F2 Large White × Minzhu intercross pig population using the PorcineSNP60 Genotyping BeadChip. The genome-wide association study identified a locus for number of ribs in a 2.38-Mb region on Sus scrofa chromosome 7 (SSC7 of Sus scrofa genome assembly, Sscrofa10.2). We identified the top significant SNP ASGA0035536, which explained 16.51 % of the phenotypic variance. A previously reported candidate causal mutation (g.19034 A>C) in vertebrae development-associated gene VRTN explained 8.79 % of the phenotypic variation on number of ribs and had a much lower effect than ASGA0035536. Haplotype sharing analysis in F1 boars localized the rib number QTL to a 951-kb interval on SSC7. This interval encompassed 17 annotated genes in Sscrofa10.2, including the previously reported VRTN candidate gene. Of the 17 candidate genes, LTBP2, which encodes a latent transforming growth factor beta binding protein, was previously reported to indirectly regulate the activity of growth differentiation factor Gdf11, which has been shown to increase the number of ribs in knock-out mice. Thus, we propose LTBP2 as a good new candidate gene for number of ribs in the pig population. This finding advances our understanding of the genetic architecture of rib number in pigs.

Counterintuitive dispersion violating Kramers-Kronig relations in gain slabs.

We demonstrate the counterintuitive dispersion effect that the peaks (dips) in the gain spectrum correspond to abnormal (normal) dispersion, contrary to the usual Kramers-Kronig point of view. This effect may also lead to two unique features: a broadband abnormal dispersion region and an observable Hartman effect. These results are explained in terms of interference and boundary effects. Finally, two experiments are proposed for the potential experimental verification.

A genome-wide association study of limb bone length using a Large White × Minzhu intercross population.

BACKGROUND: In pig, limb bone length influences ham yield and body height to a great extent and has important economic implications for pig industry. In this study, an intercross population was constructed between the indigenous Chinese Minzhu pig breed and the western commercial Large White pig breed to examine the genetic basis for variation in limb bone length. The aim of this study was to detect potential genetic variants associated with porcine limb bone length. METHODS: A total of 571 F2 individuals from a Large White and Minzhu intercross population were genotyped using the Illumina PorcineSNP60K Beadchip, and phenotyped for femur length (FL), humerus length (HL), hipbone length (HIPL), scapula length (SL), tibia length (TL), and ulna length (UL). A genome-wide association study was performed by applying the previously reported approach of genome-wide rapid association using mixed model and regression. Statistical significance of the associations was based on Bonferroni-corrected P-values. RESULTS: A total of 39 significant SNPs were mapped to a 11.93 Mb long region on pig chromosome 7 (SSC7). Linkage analysis of these significant SNPs revealed three haplotype blocks of 495 kb, 376 kb and 492 kb, respectively, in the 11.93 Mb region. Annotation based on the pig reference genome identified 15 genes that were located near or contained the significant SNPs in these linkage disequilibrium intervals. Conditioned analysis revealed that four SNPs, one on SSC2 and three on SSC4, showed significant associations with SL and HL, respectively. CONCLUSIONS: Analysis of the 15 annotated genes that were identified in these three haplotype blocks indicated that HMGA1 and PPARD, which are expressed in limbs and influence chondrocyte cell growth and differentiation, could be considered as relevant biological candidates for limb bone length in pig, with potential applications in breeding programs. Our results may also be useful for the study of the mechanisms that underlie human limb length and body height.

Increased expression of ABCB6 enhances protoporphyrin IX accumulation and photodynamic effect in human glioma.

BACKGROUND: Glioma recurrence usually occurs close to the tumor resection margins as a result of residual infiltrating glioma cells. 5-aminolevulinic acid (ALA) fluorescence-guided resection of gliomas has been demonstrated to enhance discrimination of tumor tissue and to improve survival. ALA-based photodynamic therapy is an effective albeit still experimental adjuvant treatment option for gliomas. However, insufficient protoporphyrin IX (PpIX) accumulation may limit the benefits of fluorescence-guided resection and photodynamic therapy. METHODS: We investigated the expression of the ATP-binding cassette transporter ABCB6, which regulates porphyrin synthesis, in surgical specimens from human gliomas and manipulated ABCB6 in human glioma cell lines. RESULTS: Our findings demonstrated that expression levels of ABCB6 were greatly elevated in human gliomas compared with normal brain tissues and correlated with World Health Organization histologic grade. A previously undescribed finding was that ABCB6 mRNA expression in solidly fluorescing tumor tissues was higher than that in vaguely fluorescing tumors, suggesting that ABCB6 may be at least in part responsible for PpIX accumulation in glioma cells. Accordingly, ABCB6 overexpression in glioma cell lines caused a marked increase in intracellular levels of PpIX, and was more sensitive to ALA-induced photodynamic therapy-events that could be prevented by silencing ABCB6 via siRNA treatment. CONCLUSIONS: Our findings indicate a crucial role of ABCB6 in ALA metabolism and accumulation of PpIX in glioma. ABCB6 overexpression is a potential approach to enhance accumulation of PpIX for optimizing the subjective discrimination of vague fluorescence and improving the efficacy of ALA-based photodynamic therapy.

Goos-Hänchen shifts of partially coherent light fields.

The Goos-Hänchen (GH) shift refers to a lateral displacement (from the path expected from geometrical optics) along an interface in totally internal reflection. This phenomenon results from a coherence effect. In order to bring to light the role of coherence, the reflection of partially coherent light fields was investigated within the framework of the theory of coherence. A formal expression for the GH shifts of partially coherent light fields is obtained in terms of Mercer's expansion. It is shown that both the spatial coherence and the beam width have an important effect on the GH shift, especially near the critical angles (such as totally reflection angle). These results are important to observe the GH shifts of the beams with imperfect coherence, like x-ray and matter-wave beams.

[Impact of sleep duration on cognitive functions among preschoolers].

OBJECTIVE: To explore the effect of sleep duration including napping, night sleep and total sleep duration on cognitive functions among preschoolers. METHODS: The samples consisted of 94 preschoolers, aged from 2.58 to 6.75 years, from Hangzhou and Beijing. Peabody Picture Vocabulary Test-Revised (PPVT-R), Picture Deletion Task for Preschoolers (PDTP) and Spatial Working Memory Test were applied to assess the cognitive functions of these preschoolers. Basic demographic information and sleep information were collected with self-made questionnaires. RESULTS: The results of the present study indicated that among all the participants, there were significant grade differences in napping duration and total sleep duration (F0.05(3, 90)=6.346, P=0.001; F0.05(3, 90)=2.925, P=0.038). The total sleep duration was decreased with age. However, the night sleep duration was not changed significantly with age. The correlations between the night sleep and total sleep duration and the scores of attention and working memory were significantly positive (r=0.202-0.282). No significant correlations were noted between the napping and all the scores of cognitive tests. The regression analysis showed that the total sleep duration especially the night sleep duration could well explain the variance of attention and working memory. CONCLUSION: Total sleep duration, especially night sleep duration may have great impact on preschoolers' cognitive functions, such as attention and working memory. Enough sound night sleep may help to promote the cognitive functions of the target population.

Controlling the Goos-Hänchen shift in a double prism structure using three-level Raman gain medium.

We propose a scheme to control the Goos-Hänchen (GH) shift of TE and TM reflected light beams in a double-prism structure, where a three-level Raman gain medium is filling the gap between the two prisms. We find that it is possible to control the GH shift in this structure by externally adjusting the optical properties of the Raman gain atomic medium while the gap width between the two prisms is fixed. Inspired by recent successful implementation of the double-prism configuration with an air gap to measure the GH shift, we expected that our proposal to control the GH shift can be achieved experimentally and used in different potential applications of the GH shift.