1.
Bioorg Med Chem Lett
; 12(17): 2355-8, 2002 Sep 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12161132
RESUMO
By employing a stereosimplification approach, a thorough SAR exploration of the piperidine region of Sch 206272 was possible through a practical and efficient synthesis of substituted cyclic ureas. This SAR study led to the identification of a benzimidazolinone series of compounds which display single digit nanomolar NK(1)/NK(2) affinity and near micromolar binding for the NK(3) receptor.