Controlling Surface Chemical Inhomogeneity of Ni2 P/MoNiP2 /MoP Heterostructure Electrocatalysts for Efficient Hydrogen Evolution Reaction.

Crystalline/amorphous phase engineering is demonstrated as a powerful strategy for electrochemical performance optimization. However, it is still a considerable challenge to prepare transition metal-based crystalline/amorphous heterostructures because of the low redox potential of transition metal ions. Herein, a facile H2 -assisted method is developed to prepare ternary Ni2 P/MoNiP2 /MoP crystalline/amorphous heterostructure nanowires on the conductive substrate. The characterization results show that the content of the MoNiP2 phase and the crystallinity of the MoP phase can be tuned by simply controlling the H2 concentration. The obtained electrocatalyst exhibits a superior alkaline hydrogen evolution reaction performance, delivering overpotentials of 20 and 76 mV to reach current densities of 10 and 100 mA cm-2 with a Tafel slope of 30.6 mV dec-1 , respectively. The catalysts also reveal excellent stability under a constant 100 h operation, higher than most previously reported electrocatalysts. These striking performances are ascribed to the optimized hydrogen binding energy and favorable hydrogen adsorption/desorption kinetics. This work not only exhibits the potential application of ternary Ni2 P/MoNiP2 /MoP crystalline/amorphous heterostructure nanowires catalysts for practical electrochemical water splitting, but also paves the way to prepare non-noble transition metal-based electrocatalysts with optimized crystalline/amorphous heterostructures.

Predictive role of perioperative neutrophil to lymphocyte ratio in pediatric congenital heart disease associated with pulmonary arterial hypertension.

BACKGROUND: We aimed to explore the relationship between the neutrophil to lymphocyte ratio (NLR) and the early clinical outcomes in children with congenital heart disease (CHD) associated with pulmonary arterial hypertension (PAH) after cardiac surgery. METHODS: A retrospective observational study involving 190 children from January 2013 to August 2019 was conducted. Perioperative clinical and biochemical data were collected. RESULTS: We found that pre-operative NLR was significantly correlated with AST, STB, CR and UA (P < 0.05), while post-operative NLR was significantly correlated with ALT, AST, BUN (P < 0.05). Increased post-operative neutrophil count and NLR as well as decreased lymphocyte count could be observed after cardiac surgery (P < 0.05). Level of pre-operative NLR was significantly correlated with mechanical ventilation time, ICU stay time and total length of stay (P < 0.05), while level of post-operative NLR was only significantly correlated to the first two (P < 0.05). By using ROC curve analysis, relevant areas under the curve for predicting prolonged mechanical ventilation time beyond 24 h, 48 h and 72 h by NLR were statistically significant (P < 0.05). CONCLUSION: For patients with CHD-PAH, NLR was closely related to early post-operative complications and clinical outcomes, and could act as a novel marker to predict the occurrence of prolonged mechanical ventilation.

Wearable and Ultrasensitive Strain Sensor Based on High-Quality GaN pn Junction Microwire Arrays.

With the rapid growth in wearable electronics sensing devices, flexible sensing devices that monitor the human body have shown great promise in personalized healthcare. In the study, high-quality GaN pn junction microwire arrays with different aspect ratios and large-area uniformity are fabricated through an easy, repeatable fabrication process. The piezoelectric coefficient (d33 ) of GaN pn junction microwire arrays increases from 7.23 to 14.46 pm V-1 with the increasing of the aspect ratio, which is several times higher than that of GaN bulk material. Furthermore, flexible ultrasensitive strain sensor based on GaN microwires with the highest d33 is demonstrated to achieve the maximum open circuit voltage of 10.4 V, and presents excellent durability with stable output signals over 10 000 cycles with a response time of 50 ms. As a flexible and wearable sensor attached to the human skin, the GaN microwire pn junction arrays with such a high degree of uniformity can precisely monitor subtle human pulse and motions, which show great promise in future personalized healthcare.

High-performance ß-Ga2O3 thickness dependent solar blind photodetector.

Gallium oxide (Ga2O3) has been studied as one of the most promising wide bandgap semiconductors during the past decade. Here, we prepared high quality ß-Ga2O3 films by pulsed laser deposition. ß-Ga2O3 films of different thicknesses were achieved and their crystal properties were comprehensively studied. As thickness increases, grain size and surface roughness are both increased. Based on these ß-Ga2O3 films, a series of ultraviolet (UV) photodetectors with interdigital electrodes structure were prepared. These devices embrace an ultralow dark current of 100 fA, and high photocurrent on/off ratio of 10E8 under UV light illumination. The photoresponse time is 4 ms which is faster than most of previous works. This work paves the way for the potential application of Ga2O3 in the field of UV detection.

Two-dimensional encoder with independent in-plane and out-of-plane detection for nanometric measurement.

We propose and demonstrate a new, to the best of our knowledge, optical encoder, which can measure in-plane and out-of-plane displacements simultaneously and independently. The symmetrical structure of the optical path can eliminate the impact from out-of-plane displacement on the measurement of in-plane displacement. The innovative new geometry also facilitates the multi-reflected diffracted beam to interfere with the same-order diffracted beam, so as to eliminate the impact from in-plane displacement on the measurement of out-of-plane displacement. An experimental setup is established to verify the two-dimensional independent measurement. The experiment result coincides with the one measured by two independent interferometers. The output of spectrum analysis shows that the two-dimensional independent encoder can be used for nanometric measurement.

Photogating-controlled ZnO photodetector response for visible to near-infrared light.

In recent years, as a direct wide band gap semiconductor, zinc oxide (ZnO) nanomaterial has attracted a lot of attention. However, the widely investigated ZnO materials are strongly limited in fast-response and broadband photodetectors due to their inherent weaknesses, so an effective structure or mechanism of ZnO nanostructure photodetector is greatly needed. In this work, a photogating-controlled photodetector based on a ZnO nanosheet-HfO2-lightly doped Si architecture is demonstrated. Its performance was significantly improved by the photogating-controlled local field at the Si and HfO2 interfaces compared to the findings in other published works on ZnO. Consequently, the photodetector not only effectively balances the responsivity (as high as 5.6 A W-1) and response time (400 µs), but also broadens the wavelength response of the ZnO-based photodetectors from visible to near-infrared light range (~1200 nm). Additionally, the photogating-controlled ZnO photodetector enables high-resolution imaging both in the visible and near-infrared bands. Our photogating-controlled ZnO photodetectors not only exemplify the controllability of the gate electrode in high mobility materials but also provide a basis for the development of fast speed and high responsivity detection of high mobility materials.

Residue measurement of pendimethalin in tobacco by using heart-cutting two dimensional liquid chromatography coupled with tandem mass spectrometry.

A novel heart-cutting two-dimensional liquid chromatography coupled with tandem mass spectrometry method was developed for quantitative analysis of pendimethalin residue in tobacco. The strategy of reversed phase liquid chromatography coupled with another reversed-phase liquid chromatography was employed for high column efficiency and excellent compatibility of mobile phase. In the first dimensional chromatography, a cyano column with methanol/water as the eluent was applied to separate pendimethalin from thousands of interference components in tobacco. By heart-cutting technique, which effectively removed interference components, the target compound was cut to the second dimensional C18 column for further separation. The pendimethalin residue was finally determined by the tandem mass spectrometry under multiple reaction monitoring reversed-phase liquid chromatography mode. Sample pretreatment of the new method was simplified, involving only extraction and filtration. Compared with traditional methodologies, the new method showed fairly high selectivity and sensitivity with almost no matrix interference. The limit of quantitation for pendimethalin was 1.21 ng/mL, whereas the overall recoveries ranged from 95.7 to 103.3%. The new method has been successfully applied to non-stop measure of 200 real samples, without contamination of ion source. Detection results of the samples agreed well with standard method.

Rapid profiling of cantharidin analogs in Mylabris phalerata Pallas by ultra-performance liquid chromatography-quadrupole time-of-flight-tandem mass spectrometry.

We evaluated the protective effect and toxicity of extracts from Mylabris phalerata Pallas by measuring the activated partial thromboplastin time, prothrombin time, venous thrombosis and acute toxicity in rats. Results showed the petroleum ether and water fractions of M. phalerata inhibited thrombosis but hardly prolonged the activated partial thromboplastin time and prothrombin time in rats. The trichloromethane fraction had obvious toxicity with an LD50 of 0.2 g/kg in vivo, and contained many cantharidin analogs (CAs) by ultra-performance liquid chromatography-quadrupole ion trap-tandem mass spectrometry (UPLC-QTRAP-MS/MS). CAs are the major potential bioactivity constituent in M. phalerata. An effective and reliable UPLC-QTRAP-MS/MS method was successfully developed to separate and identify CAs. The fragmentation patterns of five purified compounds were applied to elucidate the structure of their analogs. Thirty-four CAs were characterized or tentatively identified, eight of which are proposed to be novel compounds (13-17, 20, 21, 23), and their fragmentation patterns were investigated for the first time. Most importantly, a rapid and reliable UPLC-MS method was developed to identify the CAs of M. phalerata. This method has contributed to the discovery of most of these unknown analogs or their metabolites in M. phalerata effectively and quickly, and does not rely on limited chemical structural diversity libraries.

Molecule-Driven Nanoenergy Generator.

A large potential can be generated when one end of 1D and/or 2D semiconducting nanostructures such as zinc oxide (ZnO) and molybdenum disulfide is exposed to a wide spectrum of chemical molecules. A nanoenergy generator that comprises vertically aligned ZnO nanowires and poly(vinyl chloride-co-vinyl-co-2-hydroxypropyl acrylate) is fabricated, and it can generate electricity from various molecules including gaseous species exhaled from human breath. The generated voltage, which depends sensitively on the molecular dipole moment of adsorbed chemical species and surface coverage, is significantly larger than the streaming or piezoelectric potentials and is powerful enough to directly drive a single carbon nanotube field-effect transistor. It is demonstrated that the notion of voltage generation through molecule-surface interactions bears general implications to other semiconducting materials, and has the advantages of simplicity, cost-effectiveness, fast response to a wide range of molecules, and high power output, making our approach a promising tool for energy conversion and sensing applications.

Development of a heart-cutting supercritical fluid chromatography-high-performance liquid chromatography coupled to tandem mass spectrometry for the determination of four tobacco-specific nitrosamines in mainstream smoke.

This paper proposed a newly developed heart-cutting two-dimensional supercritical fluid chromatography-high-performance liquid chromatography system coupled to tandem mass spectrometry (SFC-HPLC-MS/MS) for the determination of four tobacco-specific nitrosamines (TSNAs) in cigarette mainstream smoke. The orthogonality of five SFC columns and two HPLC columns was evaluated. The 1-AA column was applied for the first dimensional (1D) SFC separation to isolate the target compounds from the complex cigarette smoke matrices, and a trapping column in conjunction with an isocratic pump was employed to capture the 1D elutes. Then, the trapped 1D elutes were transferred into the C18 column through a two-position/six-port valve for the second dimensional (2D) analysis. The ion suppression was significantly reduced by the established SFC-HPLC system; meanwhile, the matrix interferences were eliminated as the results demonstrated. A dynamic range between 0.1 and 20 ng/mL was achieved with LOQs of 0.72 µg/cig for N-nitrosonornicotine (NNN), 0.66 µg/cig for nicotine-derived nitrosamine ketone (NNK), 0.81 µg/cig for N-nitrosoanatabine (NAT), and 0.39 µg/cig for N-nitrosoanabasine (NAB). All the results revealed that the presented method exhibited good repeatabilities and recoveries and could be used as a rapid and reliable approach for routine analysis of TSNAs in mainstream smoke.

Graphene Oxide@3D Hierarchical SnO2 Nanofiber/Nanosheets Nanocomposites for Highly Sensitive and Low-Temperature Formaldehyde Detection.

In this work, we reported a formaldehyde (HCHO) gas sensor with highly sensitive and selective gas-sensing performance at low operating temperature based on graphene oxide (GO)@SnO2 nanofiber/nanosheets (NF/NSs) nanocomposites. Hierarchical SnO2 NF/NSs coated with GO nanosheets showed enhanced sensing performance for HCHO gas, especially at low operating temperature. A series of characterization methods, including X-ray diffraction (XRD), Field emission scanning electron microscopy (FE-SEM), Transmission electron microscope (TEM), X-ray photoelectron spectroscopy (XPS) and Brunauer-Emmett-Teller (BET) were used to characterize their microstructures, morphologies, compositions, surface areas and so on. The sensing performance of GO@SnO2 NF/NSs nanocomposites was optimized by adjusting the loading amount of GO ranging from 0.25% to 1.25%. The results showed the optimum loading amount of 1% GO in GO@SnO2 NF/NSs nanocomposites not only exhibited the highest sensitivity value (Ra/Rg = 280 to 100 ppm HCHO gas) but also lowered the optimum operation temperature from 120 °C to 60 °C. The response value was about 4.5 times higher than that of pure hierarchical SnO2 NF/NSs (Ra/Rg = 64 to 100 ppm). GO@SnO2 NF/NSs nanocomposites showed lower detection limit down to 0.25 ppm HCHO and excellent selectivity against interfering gases (ethanol (C2H5OH), acetone (CH3COCH3), methanol (CH3OH), ammonia (NH3), methylbenzene (C7H8), benzene (C6H6) and water (H2O)). The enhanced sensing performance for HCHO was mainly ascribed to the high specific surface area, suitable electron transfer channels and the synergistic effect of the SnO2 NF/NSs and GO nanosheets network.

Visible-Light Driven TiO2 Photocatalyst Coated with Graphene Quantum Dots of Tunable Nitrogen Doping.

Nitrogen doped graphene quantum dots (NGQDs) were successfully prepared via a hydrothermal method using citric acid and urea as the carbon and nitrogen precursors, respectively. Due to different post-treatment processes, the obtained NGQDs with different surface modifications exhibited blue light emission, while their visible-light absorption was obviously different. To further understand the roles of nitrogen dopants and N-containing surface groups of NGQDs in the photocatalytic performance, their corresponding composites with TiO2 were utilized to degrade RhB solutions under visible-light irradiation. A series of characterization and photocatalytic performance tests were carried out, which demonstrated that NGQDs play a significant role in enhancing visible-light driven photocatalytic activity and the carrier separation process. The enhanced photocatalytic activity of the NGQDs/TiO2 composites can possibly be attributed to an enhanced visible light absorption ability, and an improved separation and transfer rate of photogenerated carriers.

Graphene-Like Porous ZnO/Graphene Oxide Nanosheets for High-Performance Acetone Vapor Detection.

In order to obtain acetone sensor with excellent sensitivity, selectivity, and rapid response/recovery speed, graphene-like ZnO/graphene oxide (GO) nanosheets were synthesized using the wet-chemical method with an additional calcining treatment. The GO was utilized as both the template to form the two-dimensional (2-D) nanosheets and the sensitizer to enhance the sensing properties. Sensing performances of ZnO/GO nanocomposites were studied with acetone as a target gas. The response value could reach 94 to 100 ppm acetone vapor and the recovery time could reach 4 s. The excellent sensing properties were ascribed to the synergistic effects between ZnO nanosheets and GO, which included a unique 2-D structure, large specific surface area, suitable particle size, and abundant in-plane mesopores, which contributed to the advance of novel acetone vapor sensors and could provide some references to the synthesis of 2-D graphene-like metals oxide nanosheets.

Activation of Kagome lattice-structured Cu3V2O7(OH)2·2H2O volborthite via hydrothermal crystallization for boosting visible light-driven water oxidation.

We report a feasible strategy via hydrothermal crystallization to activate Kagome lattice-structured Cu3V2O7(OH)2·2H2O volborthite mineral as a stable visible-light-driven photocatalyst. It was demonstrated to play a crucial role in stimulating absorption ability and photodegradation performance for the removal of methylene blue present in high concentration. In contrast, direct calcination was almost ineffective, whereas post-calcination was significantly detrimental. Moreover, the photocatalytic water oxidation activity of hydrothermally crystallizated volborthite was comparable to that of BiVO4, and it was clearly higher than those of WO3 and g-C3N4 from aqueous NaIO3 solution. By further in situ decoration with an optimum amount of CoOx cocatalysts (i.e., 2 wt%), the oxygen evolution rate of volborthite was greatly enhanced, and it was 1.6-fold, 1.8-fold and 2.9-fold higher than those of BiVO4, WO3 and g-C3N4, respectively. The importance of hydrothermal crystallization can be elucidated in terms of water-Kagome lattice structure interactions involving built-in intrinsic electric field and formation of single hydrogen bonds.

Synthesis of high-purity, layered structured K2Ta4O11 intermediate phase nanocrystals for photocatalytic water splitting.

High-purity K2Ta4O11 (kalitantite) intermediate phase with a layered structure, as a new family member of alkali-metal tantalate semiconductors, was successfully prepared via a simple and cost-effective flux growth technique using potassium chloride (KCl) at a low temperature of 800 °C for only 4 h. The as-synthesized K2Ta4O11 was characterized by XRD, SEM, TEM, STEM/EDS, and UV-Vis DRS, etc. It was found that the K2Ta4O11 single nanocrystals were non-stoichiometric in the size range of 100-500 nm, and the indirect band gap of K2Ta4O11 was correctly determined to be 4.15 eV. The K2Ta4O11 not only exhibited a high and stable photocatalytic H2 generation rate of ∼45.3 µmol h(-1) g(-1) in an aqueous methanolic solution with the photodeposition of Pt as co-catalysts, but also possessed the photocatalytic ability for simultaneous evolution of H2 and O2 in a stoichiometric ratio, with loading of NiO particles as cocatalysts. Thus, it can be mainly attributed to the benefits of KCl flux lowing the reaction temperature, and increasing the surface area and crystallinity of K2Ta4O11, that the charge efficiency and enhancement of the photoreactivity for water splitting are improved.

Insights from pharmacovigilance and pharmacodynamics on cardiovascular safety signals of NSAIDs.

Background and Aim: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat fever, pain, and inflammation. Concerns regarding their cardiovascular safety have been raised. However, the underlying mechanism behind these events remains unknown. We aim to investigate the cardiovascular safety signals and receptor mechanisms of NSAIDs, employing a comprehensive approach that integrates pharmacovigilance and pharmacodynamics. Methods: This study utilized a pharmacovigilance-pharmacodynamic approach to evaluate the cardiovascular safety of NSAIDs and explore potential receptor mechanisms involved. Data were analyzed using the OpenVigil 2.1 web application, which grants access to the FDA Adverse Event Reporting System (FAERS) database, in conjunction with the BindingDB database, which provides target information on the pharmacodynamic properties of NSAIDs. Disproportionality analysis employing the Empirical Bayes Geometric Mean (EBGM) and Reporting Odds Ratio (ROR) methods was conducted to identify signals for reporting cardiovascular-related adverse drug events (ADEs) associated with 13 NSAIDs. This analysis encompassed three System Organ Classes (SOCs) associated with the cardiovascular system: blood and lymphatic system disorders, cardiac disorders, and vascular disorders. The primary targets were identified through the receptor-NSAID interaction network. Ordinary least squares (OLS) regression models explored the relationship between pharmacovigilance signals and receptor occupancy rate. Results: A total of 201,231 reports of cardiovascular-related ADEs were identified among the 13 NSAIDs. Dizziness, anemia, and hypertension were the most frequently reported Preferred Terms (PTs). Overall, nimesulide and parecoxib exhibited the strongest signal strengths of ADEs at SOC levels related to the cardiovascular system. On the other hand, our data presented naproxen and diclofenac as drugs of comparatively low signal strength. Cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) were identified as central targets. OLS regression analysis revealed that the normalized occupancy rate for either COX-1 or COX-2 was significantly inversely correlated with the log-transformed signal measures for blood and lymphatic system disorders and vascular disorders, and positively correlated with cardiac disorders and vascular disorders, respectively. This suggests that higher COX-2 receptor occupancy is associated with an increased cardiovascular risk from NSAIDs. Conclusion: Cardiovascular safety of NSAIDs may depend on pharmacodynamic properties, specifically, the percentage of the occupied cyclooxygenase isoenzymes. More studies are needed to explore these relations and improve the prescription process.

IDegLira for type 2 diabetes: a systematic review and meta-analysis.

OBJECTIVES: IDegLira is a novel fixed-ratio soluble combination of insulin degludec and the glucagon-like peptide-1 receptor agonist (GLP-1RA) liraglutide approved for type 2 diabetes (T2D) patients. Individual trials have assessed the clinical profile of IDegLira vs different comparators. We conducted a systematic review and meta-analysis to evaluate the efficacy and safety of IDegLira for T2D. METHODS: PubMed, Embase, Cochrane Library and ClinicalTrials.gov were searched from inception to August 15, 2023. The primary outcomes included change from baseline in haemoglobin A1c (HbA1c) and body weight. Risk ratios (RR), mean differences (MD), and 95% confidence intervals (CI) were calculated to evaluate the outcomes. RESULTS: This meta-analysis identified 1044 citations, and included 13 eligible trials, enroling 7773 patients. Compared with the control groups, IDegLira was optimal in change in HbA1c, percentage of patients achieving HbA1c < 7%, percentage of patients achieving HbA1c < 6.5%, HbA1c < 7.0% without weight gain and without severe or blood glucose (BG)-confirmed hypoglycaemia episodes, HbA1c < 6.5% without weight gain and without severe or BG-confirmed hypoglycaemia episodes, change in fasting plasma glucose, change in self-measured plasma glucose, change in systolic pressure, and total daily insulin dose. No difference was found between the IDegLira and control groups in terms of change in body weight, change in diastolic pressure, severe or BG-confirmed symptomatic hypoglycaemia, nocturnal severe or BG-confirmed symptomatic hypoglycaemia, adverse events or serious adverse events. CONCLUSIONS: In patients with T2D, IDegLira improved glycaemic control whilst balancing out risk for hypoglycaemia and gastrointestinal side effects.

iGlarLixi for type 2 diabetes: a systematic review and meta-analysis.

OBJECTIVES: To assess the efficacy and tolerability of iGlarLixi-a novel, fixed-ratio, soluble combination of insulin glargine and lixisenatide-for the treatment of type 2 diabetes (T2D). METHODS: The PubMed, Embase, Cochrane Library and ClinicalTrials.gov databases were searched from inception to November 15, 2023 to identify randomized controlled trials (RCTs) comparing iGlarLixi with a placebo or any other antidiabetic agent in adults with T2D. Risk ratios (RRs) and mean differences (MDs) with 95% confidence intervals (CIs) were calculated to evaluate the outcomes. RESULTS: A total of 10 trials enrolling 6071 T2D patients were included. Compared with placebos or other antidiabetic agents, iGlarLixi exerted beneficial effects on changes in HbA1c, the percentage of patients who achieved an HbA1c < 7%, the percentage of patients who achieved an HbA1c < 6.5%, the percentage of patients who achieved an HbA1c < 7.0% without weight gain and/or without severe or blood glucose-confirmed hypoglycemic episodes, changes in fasting plasma glucose, and changes in self-measured plasma glucose. Regarding safety, iGlarLixi did not increase the incidence of severe hypoglycemia or serious adverse events but did increase the incidence of gastrointestinal adverse events, symptomatic hypoglycemia, and adverse events (e.g., nausea, vomiting, diarrhea). CONCLUSIONS: iGlarLixi showed improved efficacy and safety in patients with T2D. Additional large, multicenter RCTs are warranted to obtain deeper insights into the efficacy and safety of iGlarLixi, thereby providing guidance for clinical treatment decisions.

Design and performance analysis of a new inferior vena cava filter.

This study proposes a novel inferior vena cava filter (IVCF) design, "Lotus," aiming to enhance release stability and endothelialization. A catheter-filter-vessel model was established for IVCF property analysis, validated by comparing numerical simulations and in vitro tests. Lotus's mechanical properties were analyzed, and optimization suggestions are provided. Compared to existing clinical filters, Lotus demonstrates improved release stability and thrombus capture ability. This work suggests Lotus as a potential technical reference for improved IVCF treatment.

Waterlogging in soil restricts the growth of Gleditsia sinensis seedlings and inhibits the accumulation of lignans and phenolic acids in thorns.

Gleditsia sinensis, commonly known as Chinese Zaojiao, has important economic value and medicinal compounds in its fruits and thorns, making it widely cultivated artificially in China. However, the available literature on the impact of waterlogging on the growth of G. sinensis seedlings and the accumulation of metabolite compounds in its thorns is limited. To address this knowledge gap, G. sinensis seedlings were planted in soil supplemented with pindstrup substrate, which enhances the water-holding capacity of the soil. The analyses of morphological traits and nutrient elements in one-year-old G. sinensis seedlings grown naturally under ambient conditions and metabolite accumulation in its thorns were conducted. The results showed that the waterlogged soil significantly diminished the height, fresh weight, and dry weight of seedling roots and stems (P < 0.05). Furthermore, waterlogging hindered the uptake of iron (Fe) and manganese (Mn), as well as the transport of potassium (K). The identified metabolites within the thorns were categorized into 16 distinct groups. Relative to the control soil, fatty acids and derivatives were the most down-regulated metabolites in the waterlogged soil, accounting for 40.58% of the total metabolites, followed by lignans (38.71%), phenolic acids (34.48%), saccharides and alcohols (34.15%), steroids (16.67%), alkaloids (12.24%), flavonoids (9.28%), and glycerophospholipids (7.41%). Conversely, nucleotides and derivatives experienced the greatest up-regulation in the waterlogged soil, accounting for 50.00% of the total metabolites. In conclusion, waterlogging negatively impacted the growth of G. sinensis seedlings and inhibited the accumulation of metabolites. Hence, when considering the accumulation of secondary metabolites such as lignans and phenolic acids, appropriate management of soil moisture levels should be taken into account.