Detalhe da pesquisa
1.
How insulin engages its primary binding site on the insulin receptor.
Nature
; 493(7431): 241-5, 2013 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-23302862
2.
Insulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor.
J Biol Chem
; 291(30): 15473-81, 2016 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27281820
3.
Is it time to retire the genus Rymovirus from the family Potyviridae?
Arch Virol
; 162(7): 2175-2179, 2017 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-28265774
4.
Protective hinge in insulin opens to enable its receptor engagement.
Proc Natl Acad Sci U S A
; 111(33): E3395-404, 2014 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-25092300
5.
The insulin receptor changes conformation in unforeseen ways on ligand binding: sharpening the picture of insulin receptor activation.
Bioessays
; 35(11): 945-54, doi/10.1002/bies.201370111, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24037759
6.
Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists.
Proc Natl Acad Sci U S A
; 107(15): 6771-6, 2010 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-20348418
7.
A high-affinity ErbB4Fc fusion protein is a potent antagonist of heregulin-mediated receptor activation.
Growth Factors
; 30(5): 310-9, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22856597
8.
Structure of the insulin receptor ectodomain reveals a folded-over conformation.
Nature
; 443(7108): 218-21, 2006 Sep 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-16957736
9.
The insulin and EGF receptor structures: new insights into ligand-induced receptor activation.
Trends Biochem Sci
; 32(3): 129-37, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-17280834
10.
Ligand-induced activation of the insulin receptor: a multi-step process involving structural changes in both the ligand and the receptor.
Bioessays
; 31(4): 422-34, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19274663
11.
Insulin receptor structure and its implications for the IGF-1 receptor.
Curr Opin Struct Biol
; 17(6): 699-705, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17851071
12.
A thermodynamic study of ligand binding to the first three domains of the human insulin receptor: relationship between the receptor alpha-chain C-terminal peptide and the site 1 insulin mimetic peptides.
Biochemistry
; 48(23): 5492-500, 2009 Jun 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-19459609
13.
A truncated soluble epidermal growth factor receptor-Fc fusion ligand trap displays anti-tumour activity in vivo.
Growth Factors
; 27(3): 141-54, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19333814
14.
N-linked glycans of the human insulin receptor and their distribution over the crystal structure.
Proteins
; 71(1): 426-39, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17957771
15.
A designed ankyrin repeat protein evolved to picomolar affinity to Her2.
J Mol Biol
; 369(4): 1015-28, 2007 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17466328
16.
The location and characterisation of the O-linked glycans of the human insulin receptor.
Proteins
; 66(2): 261-5, 2007 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17078079
17.
A purine analog kinase inhibitor, calcium/calmodulin-dependent protein kinase II inhibitor 59, reveals a role for calcium/calmodulin-dependent protein kinase II in insulin-stimulated glucose transport.
Endocrinology
; 148(1): 374-85, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17008397
18.
Model for the complex between the insulin-like growth factor I and its receptor: towards designing antagonists for the IGF-1 receptor.
Protein Eng Des Sel
; 19(8): 377-84, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16772308
19.
Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain.
Structure
; 24(3): 469-76, 2016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26853939
20.
Structural determinants for high-affinity binding of insulin-like growth factor II to insulin receptor (IR)-A, the exon 11 minus isoform of the IR.
Mol Endocrinol
; 18(10): 2502-12, 2004 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-15205474