Detalhe da pesquisa
1.
The genetics of drug efficacy: opportunities and challenges.
Nat Rev Genet
; 17(4): 197-206, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26972588
2.
scViewer: An Interactive Single-Cell Gene Expression Visualization Tool.
Cells
; 12(11)2023 05 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37296611
3.
Imiquimod-induced pruritus in female wild-type and knockin Wistar rats: underscoring behavioral scratching in a rat model for antipruritic treatments.
BMC Res Notes
; 16(1): 348, 2023 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38007440
4.
Disease pathology signatures in a mouse model of Mucopolysaccharidosis type IIIB.
Sci Rep
; 13(1): 16699, 2023 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37794029
5.
Deep sequencing of the LRRK2 gene in 14,002 individuals reveals evidence of purifying selection and independent origin of the p.Arg1628Pro mutation in Europe.
Hum Mutat
; 33(7): 1087-98, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22415848
6.
LRRK2 Gly2019Ser penetrance in Arab-Berber patients from Tunisia: a case-control genetic study.
Lancet Neurol
; 7(7): 591-4, 2008 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-18539535
7.
Opioid Antagonists and the A118G Polymorphism in the µ-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype.
Neuropsychopharmacology
; 43(4): 927, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29422496
8.
Pharmacogenetic meta-analysis of baseline risk factors, pharmacodynamic, efficacy and tolerability endpoints from two large global cardiovascular outcomes trials for darapladib.
PLoS One
; 12(7): e0182115, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28753643
9.
Clinical features of Parkinson disease patients with homozygous leucine-rich repeat kinase 2 G2019S mutations.
Arch Neurol
; 63(9): 1250-4, 2006 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16966502
10.
HLA-B*57:01 Confers Susceptibility to Pazopanib-Associated Liver Injury in Patients with Cancer.
Clin Cancer Res
; 22(6): 1371-7, 2016 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26546620
11.
Opioid Antagonists and the A118G Polymorphism in the µ-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype.
Neuropsychopharmacology
; 41(11): 2647-57, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27109624
12.
Association of genetic variations in HLA-B region with hypersensitivity to abacavir in some, but not all, populations.
Pharmacogenomics
; 5(2): 203-11, 2004 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15016610
13.
A low-frequency variant in MAPK14 provides mechanistic evidence of a link with myeloperoxidase: a prognostic cardiovascular risk marker.
J Am Heart Assoc
; 3(4)2014 Aug 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-25164947
14.
The effects of alcohol on the pharmacokinetics and pharmacodynamics of the selective mu-opioid receptor antagonist GSK1521498 in healthy subjects.
J Clin Pharmacol
; 53(10): 1078-90, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23934621
15.
Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes.
Diabetes
; 62(10): 3589-98, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23835345
16.
Deep resequencing unveils genetic architecture of ADIPOQ and identifies a novel low-frequency variant strongly associated with adiponectin variation.
Diabetes
; 61(5): 1297-301, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22403302
17.
An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people.
Science
; 337(6090): 100-4, 2012 Jul 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-22604722
18.
The SERPINE2 gene is associated with chronic obstructive pulmonary disease in two large populations.
Am J Respir Crit Care Med
; 176(2): 167-73, 2007 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17446335
19.
Genetic variants in the epithelial sodium channel associate with oedema in type 2 diabetic patients receiving the peroxisome proliferator-activated receptor gamma agonist farglitazar.
Pharmacogenet Genomics
; 17(12): 1065-76, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18004211
20.
Screening for Lrrk2 G2019S and clinical comparison of Tunisian and North American Caucasian Parkinson's disease families.
Mov Disord
; 22(1): 55-61, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17115391