Assuntos
Síndrome de Stevens-Johnson/terapia , Corticosteroides/uso terapêutico , Adulto , Assistência ao Convalescente , Analgesia/métodos , Curativos Biológicos , Procedimentos Clínicos , Ciclosporina/uso terapêutico , Oftalmopatias/terapia , Feminino , Doenças Urogenitais Femininas/terapia , Hidratação/métodos , Previsões , Humanos , Imunoglobulinas Intravenosas/uso terapêutico , Ativação Linfocitária , Masculino , Doenças Urogenitais Masculinas/terapia , Doenças da Boca/terapia , Apoio Nutricional/métodos , Prognóstico , Doenças Respiratórias/terapia , Higiene da Pele/métodos , Testes de Irritação da Pele/métodos , Síndrome de Stevens-Johnson/etiologia , Síndrome de Stevens-Johnson/patologiaRESUMO
The overall objective of the guideline is to provide up-to-date, evidence-based recommendations for the diagnosis and management of the full spectrum of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and SJS-TEN overlap in adults during the acute phase of the disease. The document aims to.
Assuntos
Gerenciamento Clínico , Guias de Prática Clínica como Assunto , Síndrome de Stevens-Johnson , Adulto , Diagnóstico Diferencial , Prática Clínica Baseada em Evidências , Humanos , Gravidade do Paciente , Pele/patologia , Síndrome de Stevens-Johnson/diagnóstico , Síndrome de Stevens-Johnson/fisiopatologia , Síndrome de Stevens-Johnson/terapia , Reino UnidoRESUMO
All types of leukaemia can disseminate to the skin, producing cutaneous deposits known as leukaemia cutis (LC). We undertook a retrospective study to review the clinical presentations, treatment and outcome of eight patients with LC managed in our department over a period of 12 years. The clinical phenotype varied, with erythematous papules and nodules occurring with greatest frequency. Infiltrated haemorrhagic plaques and perifollicular acneiform papules were also seen. Although patients were treated aggressively for their underlying leukaemia, and received therapy directed towards LC, they tended to be refractory to treatment and the diagnosis was generally associated with a poor prognosis. The exception was a patient with chronic lymphocytic leukaemia, who survived 3 years after developing LC.
Assuntos
Leucemia Linfocítica Crônica de Células B/patologia , Leucemia Mieloide/patologia , Infiltração Leucêmica/terapia , Pele/patologia , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Resultado do TratamentoRESUMO
Purpura fulminans is a rare syndrome of haemorrhagic necrosis of the skin and intravascular thrombosis associated with disseminated intravascular coagulopathy. It has not previously been reported as a presenting feature of Churg Strauss syndrome.
Assuntos
Síndrome de Churg-Strauss/diagnóstico , Vasculite por IgA/diagnóstico , Adulto , Síndrome de Churg-Strauss/patologia , Feminino , Humanos , Vasculite por IgA/patologiaRESUMO
The incidence of syphilis in the UK is rising, particularly in HIV-positive men. We describe a Caucasian, HIV-negative woman who presented with secondary syphilis taking the form known as lues maligna. She also demonstrated the prozone phenomenon whereby the rapid plasmin reagin test was negative, but the Venereal Disease Research Laboratory and Treponema pallidum haemagglutination tests were positive.