Detalhe da pesquisa
1.
Potent inhibitors of HIV-1 integrase display a two-step, slow-binding inhibition mechanism which is absent in a drug-resistant T66I/M154I mutant.
Biochemistry
; 48(7): 1644-53, 2009 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-19178153
2.
Relationship of potency and resilience to drug resistant mutations for GW420867X revealed by crystal structures of inhibitor complexes for wild-type, Leu100Ile, Lys101Glu, and Tyr188Cys mutant HIV-1 reverse transcriptases.
J Med Chem
; 50(10): 2301-9, 2007 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-17441703
3.
Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138.
FEBS J
; 273(16): 3850-60, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16911530
4.
Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors.
J Med Chem
; 51(16): 5000-8, 2008 Aug 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-18665583
5.
An intrinsic ATPase activity of phospho-MEK-1 uncoupled from downstream ERK phosphorylation.
Arch Biochem Biophys
; 464(1): 130-7, 2007 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17490600
6.
Crystallization of protein-ligand complexes.
Acta Crystallogr D Biol Crystallogr
; 63(Pt 1): 72-9, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17164529
7.
Antiviral activity of GW678248, a novel benzophenone nonnucleoside reverse transcriptase inhibitor.
Antimicrob Agents Chemother
; 49(10): 4046-51, 2005 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-16189079