RESUMO
A series of 6-azanaphthoquinone pyrrolo-annelated derivatives carrying different basic side chains have been synthesized. The antiproliferative activities of all compounds were evaluated on at least four different cell lines with Mitoxantrone as reference compound. Cytotoxic effects and DNA intercalation behavior were investigated.
Assuntos
Antineoplásicos/síntese química , Antineoplásicos/farmacologia , Pirróis/síntese química , Pirróis/farmacologia , Antineoplásicos/química , Linhagem Celular Tumoral , Proliferação de Células/efeitos dos fármacos , Ensaios de Seleção de Medicamentos Antitumorais , Humanos , Estrutura Molecular , Naftoquinonas/química , Pirróis/química , Relação Estrutura-AtividadeRESUMO
The bandwidth-fidelity dilemma is a controversially discussed problem in personality measurement. In this study, we contrasted the utility of broad versus narrow personality traits in an admission exam for teacher students. We compared the Big Five and narrow personality constructs (social-communicative behavior, achievement behavior, health and recreation behavior), which were part of an assessment battery for teacher student selection (N = 1120), regarding overlap and predictive validity. As criterion variables, academic satisfaction (N = 184) and GPA (N = 680) were assessed later. Reasonableness of including both questionnaires in one assessment may be questioned in terms of overlap of the personality inventories. Results show that health and recreation behavior cannot be covered by the Big Five in a selection procedure. Empirically, both broad and narrow traits show predictive validity for academic success and satisfaction.