Detalhe da pesquisa
1.
N-Terminomic Changes in Neurons During Excitotoxicity Reveal Proteolytic Events Associated With Synaptic Dysfunctions and Potential Targets for Neuroprotection.
Mol Cell Proteomics
; 22(5): 100543, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37030595
2.
GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain.
Proc Natl Acad Sci U S A
; 118(31)2021 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34330837
3.
Deletion of CaMKIIα disrupts glucose metabolism, glutamate uptake, and synaptic energetics in the cerebral cortex.
J Neurochem
; 2023 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36949663
4.
Molecular Determinants Underlying Delta Selective Compound 2 Activity at δ-Containing GABAA Receptors.
Mol Pharmacol
; 100(1): 46-56, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33990405
5.
GABAA receptor ß1 -subunit knock-out mice show increased delta power in NREM sleep and decreased theta power in REM sleep.
Eur J Neurosci
; 54(2): 4445-4455, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33942407
6.
Extensive astrocyte metabolism of γ-aminobutyric acid (GABA) sustains glutamine synthesis in the mammalian cerebral cortex.
Glia
; 68(12): 2601-2612, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32584476
7.
Pharmacological Characterization of a Betaine/GABA Transporter 1 (BGT1) Inhibitor Displaying an Unusual Biphasic Inhibition Profile and Anti-seizure Effects.
Neurochem Res
; 45(7): 1551-1565, 2020 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-32248400
8.
Lack of evidence for synaptic high-affinity γ-hydroxybutyric acid (GHB) transport in rat brain synaptosomes and 11 Na+ -dependent SLC neurotransmitter transporters.
J Neurochem
; 149(2): 195-210, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30570143
9.
Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Control Cell Surface Expression and Function.
J Biol Chem
; 292(4): 1524-1534, 2017 01 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27986810
10.
In Vitro and In Vivo Evidence for Active Brain Uptake of the GHB Analog HOCPCA by the Monocarboxylate Transporter Subtype 1.
J Pharmacol Exp Ther
; 354(2): 166-74, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25986445
11.
Pharmacological characterisation of murine α4ß1δ GABAA receptors expressed in Xenopus oocytes.
BMC Neurosci
; 16: 8, 2015 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25887256
12.
α4ßδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB).
Proc Natl Acad Sci U S A
; 109(33): 13404-9, 2012 Aug 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-22753476
13.
Pharmacological identification of a guanidine-containing ß-alanine analogue with low micromolar potency and selectivity for the betaine/GABA transporter 1 (BGT1).
Neurochem Res
; 39(10): 1988-96, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24852577
14.
Delineation of the GPRC6A receptor signaling pathways using a mammalian cell line stably expressing the receptor.
J Pharmacol Exp Ther
; 347(2): 298-309, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24008333
15.
Potency of GABA at human recombinant GABA(A) receptors expressed in Xenopus oocytes: a mini review.
Amino Acids
; 44(4): 1139-49, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23385381
16.
The L-α-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in L-arginine-induced insulin release.
Amino Acids
; 44(2): 383-90, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22714012
17.
Astrocytes regulate inhibitory neurotransmission through GABA uptake, metabolism, and recycling.
Essays Biochem
; 67(1): 77-91, 2023 03 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36806927
18.
Non-invasive detection of narcolepsy type I phenotypical features and disease progression by continuous home-cage monitoring of activity in two mouse models: the HCRT-KO and DTA model.
Sleep
; 46(9)2023 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37210587
19.
The GHB analogue HOCPCA improves deficits in cognition and sensorimotor function after MCAO via CaMKIIα.
J Cereb Blood Flow Metab
; 43(8): 1419-1434, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37026450
20.
CaMKIIα as a Promising Drug Target for Ischemic Grey Matter.
Brain Sci
; 12(12)2022 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-36552099