1.
Angew Chem Int Ed Engl
; 56(21): 5817-5820, 2017 05 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28418184
RESUMO
B(C6 F5 )3 has been found to be an effective catalyst for reduction of pyridines and other electron-deficient N-heteroarenes with hydrosilanes (or hydroboranes) and amines as the reducing reagents. The success of this development hinges upon the realization of a cascade process of dearomative hydrosilylation (or hydroboration) and transfer hydrogenation. The broad functional-group tolerance (e.g. ketone, ester, unactivated olefins, nitro, nitrile, heterocycles, etc.) implies high practical utility.