Detalhe da pesquisa
1.
The ATR inhibitor elimusertib exhibits anti-lymphoma activity and synergizes with the PI3K inhibitor copanlisib.
Br J Haematol
; 204(1): 191-205, 2024 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38011941
2.
A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy.
Bioconjug Chem
; 33(6): 1210-1221, 2022 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35658441
3.
Targeting DNA Damage Response in Prostate and Breast Cancer.
Int J Mol Sci
; 21(21)2020 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33158305
4.
Discovery of IRAK4 Inhibitors BAY1834845 (Zabedosertib) and BAY1830839.
J Med Chem
; 67(2): 1225-1242, 2024 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38228402
5.
Elimusertib has Antitumor Activity in Preclinical Patient-Derived Pediatric Solid Tumor Models.
Mol Cancer Ther
; 23(4): 507-519, 2024 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38159110
6.
Targeted thorium-227 conjugates as treatment options in oncology.
Front Med (Lausanne)
; 9: 1071086, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36726355
7.
Therapeutic targeting of ATR in alveolar rhabdomyosarcoma.
Nat Commun
; 13(1): 4297, 2022 07 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-35879366
8.
BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies.
J Med Chem
; 64(17): 12723-12737, 2021 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34428039
9.
First-in-Human Trial of the Oral Ataxia Telangiectasia and RAD3-Related (ATR) Inhibitor BAY 1895344 in Patients with Advanced Solid Tumors.
Cancer Discov
; 11(1): 80-91, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32988960
10.
Damage Incorporated: Discovery of the Potent, Highly Selective, Orally Available ATR Inhibitor BAY 1895344 with Favorable Pharmacokinetic Properties and Promising Efficacy in Monotherapy and in Combination Treatments in Preclinical Tumor Models.
J Med Chem
; 63(13): 7293-7325, 2020 07 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32502336
11.
The Novel ATR Inhibitor BAY 1895344 Is Efficacious as Monotherapy and Combined with DNA Damage-Inducing or Repair-Compromising Therapies in Preclinical Cancer Models.
Mol Cancer Ther
; 19(1): 26-38, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31582533
12.
Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase.
J Med Chem
; 63(15): 8025-8042, 2020 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32338514
13.
Synergistic Effect of a Mesothelin-Targeted 227Th Conjugate in Combination with DNA Damage Response Inhibitors in Ovarian Cancer Xenograft Models.
J Nucl Med
; 60(9): 1293-1300, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30850485
14.
Preclinical Combination Studies of an FGFR2 Targeted Thorium-227 Conjugate and the ATR Inhibitor BAY 1895344.
Int J Radiat Oncol Biol Phys
; 105(2): 410-422, 2019 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31255687
15.
BAY 1143269, a novel MNK1 inhibitor, targets oncogenic protein expression and shows potent anti-tumor activity.
Cancer Lett
; 390: 21-29, 2017 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28043914
16.
Simultaneous Inhibition of PI3Kδ and PI3Kα Induces ABC-DLBCL Regression by Blocking BCR-Dependent and -Independent Activation of NF-κB and AKT.
Cancer Cell
; 31(1): 64-78, 2017 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28073005
17.
Novel Mps1 Kinase Inhibitors with Potent Antitumor Activity.
Mol Cancer Ther
; 15(4): 583-92, 2016 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26832791
18.
BAY 1000394, a novel cyclin-dependent kinase inhibitor, with potent antitumor activity in mono- and in combination treatment upon oral application.
Mol Cancer Ther
; 11(10): 2265-73, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22821149
19.
Differential mobilization of subsets of progenitor cells from the bone marrow.
Cell Stem Cell
; 4(1): 62-72, 2009 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-19128793
20.
The coordinated action of G-CSF and ELR + CXC chemokines in neutrophil mobilization during acute inflammation.
Blood
; 111(1): 42-9, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17928531