Detalhe da pesquisa
1.
Vaccination with structurally adapted fungal protein fibrils induces immunity to Parkinson's disease.
Brain
; 147(5): 1644-1652, 2024 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38428032
2.
Prion protein with a mutant N-terminal octarepeat region undergoes cobalamin-dependent assembly into high-molecular weight complexes.
J Biol Chem
; 298(4): 101770, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35271850
3.
Asymmetric-flow field-flow fractionation of prions reveals a strain-specific continuum of quaternary structures with protease resistance developing at a hydrodynamic radius of 15 nm.
PLoS Pathog
; 17(6): e1009703, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34181702
4.
The ultrastructure of infectious L-type bovine spongiform encephalopathy prions constrains molecular models.
PLoS Pathog
; 17(6): e1009628, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34061899
5.
New and distinct chronic wasting disease strains associated with cervid polymorphism at codon 116 of the Prnp gene.
PLoS Pathog
; 17(7): e1009795, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34310662
6.
In Vitro and In Vivo Evidence towards Fibronectin's Protective Effects against Prion Infection.
Int J Mol Sci
; 24(24)2023 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38139358
7.
Aggregation of Aß40/42 chains in the presence of cyclic neuropeptides investigated by molecular dynamics simulations.
PLoS Comput Biol
; 17(3): e1008771, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33711010
8.
Essential collective dynamics analysis reveals nonlocal interactions of alpha-synuclein38-95 monomers with fibrillar seeds.
J Chem Phys
; 157(23): 235101, 2022 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36550041
9.
Unconjugated PLGA nanoparticles attenuate temperature-dependent ß-amyloid aggregation and protect neurons against toxicity: implications for Alzheimer's disease pathology.
J Nanobiotechnology
; 20(1): 67, 2022 Feb 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35120558
10.
Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints.
Nucleic Acids Res
; 48(19): 10615-10631, 2020 11 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32776089
11.
Native nanodiscs formed by styrene maleic acid copolymer derivatives help recover infectious prion multimers bound to brain-derived lipids.
J Biol Chem
; 295(25): 8460-8469, 2020 06 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32358064
12.
Full atomistic model of prion structure and conversion.
PLoS Pathog
; 15(7): e1007864, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31295325
13.
Isolation of infectious, non-fibrillar and oligomeric prions from a genetic prion disease.
Brain
; 143(5): 1512-1524, 2020 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32303068
14.
A novel Gerstmann-Sträussler-Scheinker disease mutation defines a precursor for amyloidogenic 8 kDa PrP fragments and reveals N-terminal structural changes shared by other GSS alleles.
PLoS Pathog
; 14(1): e1006826, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29338055
15.
Diverse, evolving conformer populations drive distinct phenotypes in frontotemporal lobar degeneration caused by the same MAPT-P301L mutation.
Acta Neuropathol
; 139(6): 1045-1070, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32219515
16.
Destabilizing polymorphism in cervid prion protein hydrophobic core determines prion conformation and conversion efficiency.
PLoS Pathog
; 13(8): e1006553, 2017 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-28800624
17.
A Neuronal Culture System to Detect Prion Synaptotoxicity.
PLoS Pathog
; 12(5): e1005623, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27227882
18.
The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy.
PLoS Pathog
; 12(9): e1005835, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27606840
19.
Neuroinvasion of α-Synuclein Prionoids after Intraperitoneal and Intraglossal Inoculation.
J Virol
; 90(20): 9182-93, 2016 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27489279
20.
Toll-like receptor-mediated immune response inhibits prion propagation.
Glia
; 64(6): 937-51, 2016 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-26880394