Detalhe da pesquisa
1.
Analysis of the complex between MBD2 and the histone deacetylase core of NuRD reveals key interactions critical for gene silencing.
Proc Natl Acad Sci U S A
; 120(33): e2307287120, 2023 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37552759
2.
MBD2a-NuRD binds to the methylated γ-globin gene promoter and uniquely forms a complex required for silencing of HbF expression.
Proc Natl Acad Sci U S A
; 120(25): e2302254120, 2023 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37307480
3.
Physics-Informed Generative Model for Drug-like Molecule Conformers.
J Chem Inf Model
; 64(8): 2988-3007, 2024 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38486425
4.
Densely methylated DNA traps Methyl-CpG-binding domain protein 2 but permits free diffusion by Methyl-CpG-binding domain protein 3.
J Biol Chem
; 298(10): 102428, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36037972
5.
Comparison of outcomes after appendectomy in First Nations and non-First Nations patients in Northern Alberta.
Can J Surg
; 66(6): E540-E549, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37967970
6.
Disruption of the MBD2-NuRD complex but not MBD3-NuRD induces high level HbF expression in human adult erythroid cells.
Haematologica
; 104(12): 2361-2371, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31004025
7.
CpG and methylation-dependent DNA binding and dynamics of the methylcytosine binding domain 2 protein at the single-molecule level.
Nucleic Acids Res
; 45(15): 9164-9177, 2017 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28637186
8.
A MEIG1/PACRG complex in the manchette is essential for building the sperm flagella.
Development
; 142(5): 921-30, 2015 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25715396
9.
An intrinsically disordered region of methyl-CpG binding domain protein 2 (MBD2) recruits the histone deacetylase core of the NuRD complex.
Nucleic Acids Res
; 43(6): 3100-13, 2015 Mar 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-25753662
10.
The utility of thyroid ultrasonography in the management of thyroid nodules.
Can J Surg
; 60(2): 134-139, 2017 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-28338469
11.
Solution structure and intramolecular exchange of methyl-cytosine binding domain protein 4 (MBD4) on DNA suggests a mechanism to scan for mCpG/TpG mismatches.
Nucleic Acids Res
; 42(17): 11218-32, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25183517
12.
Probing the dynamic distribution of bound states for methylcytosine-binding domains on DNA.
J Biol Chem
; 289(3): 1294-302, 2014 Jan 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-24307175
13.
Mi2ß-mediated silencing of the fetal γ-globin gene in adult erythroid cells.
Blood
; 121(17): 3493-501, 2013 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-23444401
14.
Unique features of the anti-parallel, heterodimeric coiled-coil interaction between methyl-cytosine binding domain 2 (MBD2) homologues and GATA zinc finger domain containing 2A (GATAD2A/p66α).
J Biol Chem
; 288(5): 3419-27, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23239876
15.
Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process.
Blood
; 119(25): 6089-98, 2012 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22446485
16.
p66Alpha-MBD2 coiled-coil interaction and recruitment of Mi-2 are critical for globin gene silencing by the MBD2-NuRD complex.
Proc Natl Acad Sci U S A
; 108(18): 7487-92, 2011 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-21490301
17.
A fear conditioned cue orchestrates a suite of behaviors in rats.
Elife
; 132024 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38770736
18.
Solution structure and dynamic analysis of chicken MBD2 methyl binding domain bound to a target-methylated DNA sequence.
Nucleic Acids Res
; 39(15): 6741-52, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21531701
19.
Evaluation of acyllysine isostere interactions with the aromatic pocket of the AF9 YEATS domain.
Protein Sci
; 32(1): e4533, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36482045
20.
Discovery of novel N-acylpyrazoles as potent and selective thrombin inhibitors.
Eur J Med Chem
; 246: 114855, 2023 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36462436