Detalhe da pesquisa
1.
Structure-activity relationships of 2-pyrimidinecarbohydrazides as utrophin modulators for the potential treatment of Duchenne muscular dystrophy.
Bioorg Med Chem
; 69: 116812, 2022 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35772287
2.
Characterisation of utrophin modulator SMT C1100 as a non-competitive inhibitor of firefly luciferase.
Bioorg Chem
; 94: 103395, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31733898
3.
Synthesis of SMT022357 enantiomers and in vivo evaluation in a Duchenne muscular dystrophy mouse model.
Tetrahedron
; 76(2): 130819, 2020 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32713969
4.
Chemical Proteomics and Phenotypic Profiling Identifies the Aryl Hydrocarbon Receptor as a Molecular Target of the Utrophin Modulator Ezutromid.
Angew Chem Int Ed Engl
; 59(6): 2420-2428, 2020 02 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31755636
5.
Second-generation compound for the modulation of utrophin in the therapy of DMD.
Hum Mol Genet
; 24(15): 4212-24, 2015 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25935002
6.
General synthesis of sugar-derived azepane nitrones: precursors of azepane iminosugars.
J Org Chem
; 78(7): 3208-21, 2013 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-23458237
7.
Synthesis of eight stereoisomers of pochonicine: nanomolar inhibition of ß-N-acetylhexosaminidases.
J Org Chem
; 78(20): 10298-309, 2013 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24032658
8.
C-branched iminosugars: α-glucosidase inhibition by enantiomers of isoDMDP, isoDGDP, and isoDAB-L-isoDMDP compared to miglitol and miglustat.
J Org Chem
; 78(15): 7380-97, 2013 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-23688199
9.
Scalable syntheses of both enantiomers of DNJNAc and DGJNAc from glucuronolactone: the effect of N-alkylation on hexosaminidase inhibition.
Chemistry
; 18(30): 9341-59, 2012 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-22736508
10.
Discovery and SAR of 2-arylbenzotriazoles and 2-arylindazoles as potential treatments for Duchenne muscular dystrophy.
Bioorg Med Chem Lett
; 21(16): 4828-31, 2011 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21741236
11.
6-De-oxy-3,4-O-isopropyl-idene-2-C-methyl-l-galactono-1,5-lactone.
Acta Crystallogr Sect E Struct Rep Online
; 67(Pt 9): o2531-2, 2011 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22059064
12.
Targeted microbiome-sparing antibiotics.
Drug Discov Today
; 26(9): 2198-2203, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34329771
13.
Discovery and mechanism of action studies of 4,6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy.
Eur J Med Chem
; 220: 113431, 2021 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33915371
14.
6-De-oxy-6-fluoro-d-galactose.
Acta Crystallogr Sect E Struct Rep Online
; 66(Pt 6): o1315, 2010 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-21579408
15.
1-De-oxy-1-fluoro-l-galactitol.
Acta Crystallogr Sect E Struct Rep Online
; 66(Pt 6): o1330, 2010 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-21579420
16.
Decreasing HepG2 Cytotoxicity by Lowering the Lipophilicity of Benzo[d]oxazolephosphinate Ester Utrophin Modulators.
ACS Med Chem Lett
; 11(12): 2421-2427, 2020 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33335663
17.
2-Arylbenzo[d]oxazole Phosphinate Esters as Second-Generation Modulators of Utrophin for the Treatment of Duchenne Muscular Dystrophy.
J Med Chem
; 63(14): 7880-7891, 2020 07 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32551645
18.
Isolation, Structural Identification, Synthesis, and Pharmacological Profiling of 1,2-trans-Dihydro-1,2-diol Metabolites of the Utrophin Modulator Ezutromid.
J Med Chem
; 63(5): 2547-2556, 2020 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31599580
19.
(2S,3R,4R,5R)-3,4-Dihydr-oxy-5-(hydroxy-meth-yl)pyrrolidine-2-carboxylic acid [(2S,3R,4R,5R)-3,4-dihydr-oxy-5-(hydroxy-meth-yl)proline].
Acta Crystallogr Sect E Struct Rep Online
; 65(Pt 10): o2418-9, 2009 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-21577876
20.
Steviamine, a new class of indolizidine alkaloid [(1R,2S,3R,5R,8aR)-3-hydroxy-meth-yl-5-methyl-octa-hydro-indolizine-1,2-diol hydro-bromide].
Acta Crystallogr Sect E Struct Rep Online
; 65(Pt 11): o2904-5, 2009 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-21578486