Detalhe da pesquisa
1.
Identification and structural validation of purine nucleoside phosphorylase from Plasmodium falciparum as a target of MMV000848.
J Biol Chem
; 300(1): 105586, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38141766
2.
Short tandem repeat polymorphism in the promoter region of cyclophilin 19B drives its transcriptional upregulation and contributes to drug resistance in the malaria parasite Plasmodium falciparum.
PLoS Pathog
; 19(1): e1011118, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36696458
3.
A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Nature
; 522(7556): 315-20, 2015 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26085270
4.
A comprehensive RNA handling and transcriptomics guide for high-throughput processing of Plasmodium blood-stage samples.
Malar J
; 19(1): 363, 2020 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33036628
5.
UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.
Antimicrob Agents Chemother
; 62(9)2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29941635
6.
Plasmodium falciparum and Plasmodium vivax Demonstrate Contrasting Chloroquine Resistance Reversal Phenotypes.
Antimicrob Agents Chemother
; 61(8)2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28533239
7.
Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Nature
; 537(7618): 122, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27281209
8.
Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling.
PLoS Med
; 13(10): e1002138, 2016 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-27701420
9.
Expression of Plasmodium vivax crt-o Is Related to Parasite Stage but Not Ex Vivo Chloroquine Susceptibility.
Antimicrob Agents Chemother
; 60(1): 361-7, 2016 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26525783
10.
Analysis of ex vivo drug response data of Plasmodium clinical isolates: the pros and cons of different computer programs and online platforms.
Malar J
; 15: 137, 2016 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26935745
11.
Contrasting ex vivo efficacies of "reversed chloroquine" compounds in chloroquine-resistant Plasmodium falciparum and P. vivax isolates.
Antimicrob Agents Chemother
; 59(9): 5721-6, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26149984
12.
Potent Ex Vivo Activity of Naphthoquine and Methylene Blue against Drug-Resistant Clinical Isolates of Plasmodium falciparum and Plasmodium vivax.
Antimicrob Agents Chemother
; 59(10): 6117-24, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26195523
13.
Quantification of Plasmodium ex vivo drug susceptibility by flow cytometry.
Malar J
; 14: 417, 2015 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26498665
14.
KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission.
Antimicrob Agents Chemother
; 58(9): 5060-7, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24913172
15.
Sterile protection against P. vivax malaria by repeated blood stage infection in the Aotus monkey model.
Life Sci Alliance
; 7(3)2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38158220
16.
Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development.
Cell Chem Biol
; 31(4): 743-759.e8, 2024 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38593807
17.
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity.
mBio
; : e0096624, 2024 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38717141
18.
Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria".
Antimicrob Agents Chemother
; 62(11)2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30355750
19.
Comparative ex vivo activity of novel endoperoxides in multidrug-resistant plasmodium falciparum and P. vivax.
Antimicrob Agents Chemother
; 56(10): 5258-63, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22850522
20.
Longitudinal ex vivo and molecular trends of chloroquine and piperaquine activity against Plasmodium falciparum and P. vivax before and after introduction of artemisinin-based combination therapy in Papua, Indonesia.
Int J Parasitol Drugs Drug Resist
; 17: 46-56, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34193398