Detalhe da pesquisa
1.
Mitochondrial Effects of Hydromethylthionine, Rivastigmine and Memantine in Tau-Transgenic Mice.
Int J Mol Sci
; 24(13)2023 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37445987
2.
Exploring the Anti-Hypoxaemia Effect of Hydromethylthionine: A Prospective Study of Phase 3 Clinical Trial Participants.
Int J Mol Sci
; 24(18)2023 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37762050
3.
Hydromethylthionine enhancement of central cholinergic signalling is blocked by rivastigmine and memantine.
J Neurochem
; 160(2): 172-184, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34855998
4.
Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the line 66 model of frontotemporal dementia.
J Biol Chem
; 295(52): 18508-18523, 2020 12 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33127647
5.
Current Progress and Future Directions for Tau-Based Fluid Biomarker Diagnostics in Alzheimer's Disease.
Int J Mol Sci
; 21(22)2020 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33212983
6.
Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial.
Lancet
; 388(10062): 2873-2884, 2016 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27863809
7.
Cellular Models of Aggregation-dependent Template-directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer Disease.
J Biol Chem
; 290(17): 10862-75, 2015 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-25759392
8.
Complex disposition of methylthioninium redox forms determines efficacy in tau aggregation inhibitor therapy for Alzheimer's disease.
J Pharmacol Exp Ther
; 352(1): 110-8, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25320049
9.
Effects of oxidized and reduced forms of methylthioninium in two transgenic mouse tauopathy models.
Behav Pharmacol
; 26(4): 353-68, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25769090
10.
A Meta-Analysis on Presynaptic Changes in Alzheimer's Disease.
J Alzheimers Dis
; 97(1): 145-162, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38073390
11.
Solubility of α-synuclein species in the L62 mouse model of synucleinopathy.
Sci Rep
; 14(1): 6239, 2024 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38486089
12.
Considerations for biomarker strategies in clinical trials investigating tau-targeting therapeutics for Alzheimer's disease.
Transl Neurodegener
; 13(1): 25, 2024 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38773569
13.
Assays for the Screening and Characterization of Tau Aggregation Inhibitors.
Methods Mol Biol
; 2754: 93-104, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38512662
14.
Hydromethylthionine rescues synaptic SNARE proteins in a mouse model of tauopathies: Interference by cholinesterase inhibitors.
Brain Res Bull
; 212: 110955, 2024 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38677558
15.
Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model.
Cells
; 13(7)2024 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38607082
16.
LETC inhibits α-Syn aggregation and ameliorates motor deficiencies in the L62 mouse model of synucleinopathy.
Eur J Pharmacol
; 970: 176505, 2024 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38503400
17.
Utility of Blood-Based Tau Biomarkers for Mild Cognitive Impairment and Alzheimer's Disease: Systematic Review and Meta-Analysis.
Cells
; 12(8)2023 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37190093
18.
An Additive-Free Model for Tau Self-Assembly.
Methods Mol Biol
; 2551: 163-188, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36310203
19.
Crossed cerebellar diaschisis in Alzheimer's disease.
Nucl Med Commun
; 43(4): 423-427, 2022 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35081090
20.
Structural Identification of Individual Helical Amyloid Filaments by Integration of Cryo-Electron Microscopy-Derived Maps in Comparative Morphometric Atomic Force Microscopy Image Analysis.
J Mol Biol
; 434(7): 167466, 2022 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35077765