Detalhe da pesquisa
1.
NMR spectroscopy: the swiss army knife of drug discovery.
J Biomol NMR
; 74(10-11): 509-519, 2020 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-32617727
2.
Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators.
Biochem J
; 473(5): 581-92, 2016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26635351
3.
Glycomimetic ligands for the human asialoglycoprotein receptor.
J Am Chem Soc
; 134(4): 1978-81, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22280495
4.
Design of a multi-purpose fragment screening library using molecular complexity and orthogonal diversity metrics.
J Comput Aided Mol Des
; 25(7): 621-36, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21604056
5.
Intramolecular Ring-Opening Decomposition of Aryl Azetidines.
ACS Med Chem Lett
; 12(10): 1585-1588, 2021 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34676040
6.
PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease.
J Med Chem
; 64(1): 326-342, 2021 01 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33356244
7.
Aminopyrazole Carboxamide Bruton's Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning.
ACS Med Chem Lett
; 10(1): 80-85, 2019 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30655951
8.
Molecular features crucial to the activity of pyrimidine benzamide-based thrombopoietin receptor agonists.
Bioorg Med Chem Lett
; 18(9): 3000-6, 2008 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18396041
9.
Biophysical Interactions of Direct AMPK Activators.
Methods Mol Biol
; 1732: 29-55, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29480467
10.
An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes.
Structure
; 26(4): 533-544.e3, 2018 04 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29576321
11.
Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK).
J Med Chem
; 61(6): 2372-2383, 2018 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29466005
12.
Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK).
J Med Chem
; 60(18): 7835-7849, 2017 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-28853885
13.
Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists.
Sci Rep
; 6: 30859, 2016 08 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-27527709
14.
Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide.
Sci Rep
; 6: 26071, 2016 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-27184415
15.
Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy.
J Med Chem
; 59(17): 8068-81, 2016 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27490827
16.
Short Hydrophobic Peptides with Cyclic Constraints Are Potent Glucagon-like Peptide-1 Receptor (GLP-1R) Agonists.
J Med Chem
; 58(9): 4080-5, 2015 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-25839426
17.
Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro.
Chem Biol
; 21(2): 284-94, 2014 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-24440079
18.
Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms.
Structure
; 22(8): 1161-1172, 2014 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25066137
19.
Spirocyclic sulfamides as ß-secretase 1 (BACE-1) inhibitors for the treatment of Alzheimer's disease: utilization of structure based drug design, WaterMap, and CNS penetration studies to identify centrally efficacious inhibitors.
J Med Chem
; 55(21): 9224-39, 2012 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22984865
20.
Discovery and optimization of a novel spiropyrrolidine inhibitor of ß-secretase (BACE1) through fragment-based drug design.
J Med Chem
; 55(21): 9069-88, 2012 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22468999