Vasopressin and parental expressed emotion in the transition to fatherhood.

In the last decades, parenting researchers increasingly focused on the role of fathers in child development. However, it is still largely unknown which factors contribute to fathers' beliefs about their child, which may be crucial in the transition to fatherhood. In the current randomized within-subject experiment, the effect of nasal administration of vasopressin (AVP) on both Five Minute Speech Sample-based (FMSS) expressed emotion and emotional content or prosody was explored in 25 prospectivefathers. Moreover, we explored how the transition to fatherhood affected these FMSS-based parameters, using prenatal and early postnatal measurements. Analyses revealed that FMSS-based expressed emotion and emotional content were correlated, but not affected by prenatal AVP administration. However,child's birth was associated with an increase in positivity and a decrease in emotional prosody, suggesting that the child's birth is more influential with regard to paternal thoughts and feelings than prenatal AVP administration.

Effects of vasopressin on neural processing of infant crying in expectant fathers.

In a randomized, double blind, placebo-controlled, within-subject magnetic resonance imaging study, we examined the effect of 20 IU intranasal vasopressin on the neural processing of infant crying in 25 fathers-to-be. We explored whether familial background modulates vasopressin effects, and whether vasopressin differentially affects cry processing coupled with neutral or emotional contextual information. Participants listened to cries accompanied by neutral ('this is an infant') or emotional ('this infant is sick/bored') contextual information, and neutral control sounds ('this is a saw'). Additionally, participants reported on their childhood experiences of parental love-withdrawal and abuse. Infant crying (vs control sounds) was associated with increased activation in the bilateral auditory cortex and posterior medial cortex. No effects of vasopressin were found in this 'cry network'. Exploratory whole-brain analyses suggested that effects of vasopressin in the anterior cingulate cortex, paracingulate gyrus and supplemental motor area were stronger in fathers who experienced lower (vs higher) levels of love-withdrawal. No interaction was observed for abuse. Vasopressin increased activation in response to cries accompanied by emotional vs neutral contextual information in several brain regions, e.g. the cerebellum, brainstem (midbrain), posterior medial cortex, hippocampus, putamen, and insula. Our results suggest that the experience of love-withdrawal may modulate the vasopressin system, influencing effects of vasopressin administration on cry processing. Results further suggest a role for vasopressin in the processing of cry sounds with emotional contextual information.

Brain reactivity to alcohol and cannabis marketing during sobriety and intoxication.

Drugs of abuse stimulate striatal dopamine release and activate reward pathways. This study examined the impact of alcohol and cannabis marketing on the reward circuit in alcohol and cannabis users while sober and intoxicated. It was predicted that alcohol and cannabis marketing would increase striatal activation when sober and that reward sensitivity would be less during alcohol and cannabis intoxication. Heavy alcohol (n = 20) and regular cannabis users (n = 21) participated in a mixed factorial study involving administration of alcohol and placebo in the alcohol group and cannabis and placebo in the cannabis group. Non-drug users (n = 20) served as between group reference. Brain activation after exposure to alcohol and cannabis marketing movies was measured using functional magnetic resonance imaging and compared between groups while sober and compared with placebo while intoxicated. Implicit alcohol and cannabis cognitions were assessed by means of a single-category implicit association test. Alcohol and cannabis marketing significantly increased striatal BOLD activation across all groups while sober. Striatal activation however decreased during intoxication with alcohol and cannabis. Implicit associations with cannabis marketing cues were significantly more positive in alcohol and cannabis users as compared with non-drug using controls. Public advertising of alcohol or cannabis use elicits striatal activation in the brain's reward circuit. Reduction of marketing would reduce brain exposure to reward cues that motivate substance use. Conversely, elevated dopamine levels protect against the reinforcing potential of marketing.

The nature of hemispheric specialization for prosody perception.

Recent evidence suggests a relative right-hemispheric specialization for emotional prosody perception, whereas linguistic prosody perception is under bilateral control. It is still unknown, however, how the hemispheric specialization for prosody perception might arise. Two main hypotheses have been put forward. Cue-dependent hypotheses, on the one hand, propose that hemispheric specialization is driven by specialization for the non-prosody-specific processing of acoustic cues. The functional lateralization hypothesis, on the other hand, proposes that hemispheric specialization is dependent on the communicative function of prosody, with emotional and linguistic prosody processing being lateralized to the right and left hemispheres, respectively. In the present study, the functional lateralization hypothesis of prosody perception was systematically tested by instructing one group of participants to evaluate the emotional prosody, and another group the linguistic prosody dimension of bidimensional prosodic stimuli in a dichotic-listening paradigm, while event-related potentials were recorded. The results showed that the right-ear advantage was associated with decreased latencies for an early negativity in the contralateral hemisphere. No evidence was found for functional lateralization. These findings suggest that functional lateralization effects for prosody perception are small and support the structural model of dichotic listening.

EXPRESS: The role of animacy in language production: evidence from bare noun naming.

According to Levelt's language production model, in order to name an object, speakers must first conceptualize and lexicalize the object before its name can be articulated. Conceptualization is conducted through the semantic network that exists at the conceptual level, with the highly activated concept(s) activating lexical items at the lemma-level, i.e., lexicalization. So far, research focused mostly on semantic categories (i.e., semantic interference) but less so on animacy - a concept that is correlated with semantic categories. To investigate the role of this semantic feature in language production, we conducted a picture-word interference study in Mandarin Chinese varying animacy congruency and controlling for classifier congruency while recording behavioral and electrophysiological responses. We observed an animacy interference effect together with a larger N400 component for animacy-incongruent vs. congruent picture-word pairs, suggesting animacy-congruent concepts may be in closer proximity and hence lead to a stronger spreading of activation relative to animacy-incongruent concepts. Furthermore, a larger P600 component was observed for classifier-incongruent vs. congruent picture-word pairs, suggesting syntactically-driven processing of classifiers at the lemma level.

The nature of affective priming in music and speech.

The phenomenon of affective priming has caught scientific interest for over 30 years, yet the nature of the affective priming effect remains elusive. This study investigated the underlying mechanism of cross-modal affective priming and the influence of affective incongruence in music and speech on negativities in the N400 time-window. In Experiment 1, participants judged the valence of affective targets (affective categorization). We found that music and speech targets were evaluated faster when preceded by affectively congruent visual word primes, and vice versa. This affective priming effect was accompanied by a significantly larger N400-like effect following incongruent targets. In this experiment, both spreading of activation and response competition could underlie the affective priming effect. In Experiment 2, participants categorized the same affective targets based on nonaffective characteristics. However, as prime valence was irrelevant to the response dimension, affective priming effects could no longer be attributable to response competition. In Experiment 2, affective priming effects were observed neither at the behavioral nor electrophysiological level. The results of this study indicate that both affective music and speech prosody can prime the processing of visual words with emotional connotations, and vice versa. Affective incongruence seems to be associated with N400-like effects during evaluative categorization. The present data further suggest a role of response competition during the affective categorization of music, prosody, and words with emotional connotations.

Exploring the neural basis for paternal protection: an investigation of the neural response to infants in danger.

Perceiving potential threat to an infant and responding to it is crucial for offspring survival and parent-child bonding. Using a combination of functional magnetic resonance imaging and multi-informant reports, this longitudinal study explores the neural basis for paternal responses to threat to infants pre-natally (N = 21) and early post-natally (n = 17). Participants viewed videos showing an infant in danger and matched control videos, while instructed to imagine that the infant was their own or someone else's. Effects were found for infant-threatening vs neutral situations in the amygdala (region-of-interest analyses) and in clusters spanning cortical and subcortical areas (whole-brain analyses). An interaction effect revealed increased activation for own (vs unknown) infants in threatening (vs neutral) situations in bilateral motor areas, possibly indicating preparation for action. Post-natal activation patterns were similar; however, in part of the superior frontal gyrus the distinction between threat to own and unknown infant faded. Fathers showing more protective behavior in daily life recruited part of the frontal pole more when confronted with threat to their own vs an unknown infant. This exploratory study is the first to describe neural mechanisms involved in paternal protection and provides a basis for future work on fathers' protective parenting.

Vasopressin Differentially Affects Handgrip Force of Expectant Fathers in Reaction to Own and Unknown Infant Faces.

The underlying mechanisms of paternal responses to infant signals are poorly understood. Vasopressin has previously been proposed to affect these responses. Using a double-blind, placebo-controlled, within-subject design (N = 25 expectant fathers), we examined the effect of vasopressin administration on the use of excessive handgrip force during exposure to infant crying versus matched control sounds, while participants saw morphed images representing their own infant versus an unknown infant. We found that, compared to placebo, AVP administration elicited more excessive force while viewing an unknown infant image compared to viewing the image representing one's own infant, while the reverse was true under placebo. The results are discussed in light of vasopressin's role in parenting and parental protection among human fathers.

High amyloid burden is associated with fewer specific words during spontaneous speech in individuals with subjective cognitive decline.

Self-perceived word-finding difficulties are common in aging individuals as well as in Alzheimer's Disease (AD). Language and speech deficits are difficult to objectify with neuropsychological assessments. We therefore aimed to investigate whether amyloid, an early AD pathological hallmark, is associated with speech-derived semantic complexity. We included 63 individuals with subjective cognitive decline (age 64 ±â€¯8, MMSE 29 ±â€¯1), with amyloid status (positron emission tomography [PET] scans n = 59, or Aß1-42 cerebrospinal fluid [CSF] n = 4). Spontaneous speech was recorded using three open-ended tasks (description of cookie theft picture, abstract painting and a regular Sunday), transcribed verbatim and subsequently, linguistic parameters were extracted using T-scan computational software, including specific words (content words, frequent, concrete and abstract nouns, and fillers), lexical complexity (lemma frequency, Type-Token-Ratio) and syntactic complexity (Developmental Level scale). Nineteen individuals (30%) had high levels of amyloid burden, and there were no differences between groups on conventional neuropsychological tests. Using multinomial regression with linguistic parameters (in tertiles), we found that high amyloid burden is associated with fewer concrete nouns (ORmiddle (95%CI): 7.6 (1.4-41.2), ORlowest: 6.7 (1.2-37.1)) and content words (ORlowest: 6.3 (1.0-38.1). In addition, we found an interaction for education between high amyloid burden and more abstract nouns. In conclusion, high amyloid burden was modestly associated with fewer specific words, but not with syntactic complexity, lexical complexity or conventional neuropsychological tests, suggesting that subtle spontaneous speech deficits might occur in preclinical AD.

Cue reactivity and its relation to craving and relapse in alcohol dependence: a combined laboratory and field study.

The present study investigated the nature of physiological cue reactivity and craving in response to alcohol cues among alcohol-dependent patients (N = 80) who were enrolled in detoxification treatment. Further, the predictive value with regard to future drinking of both the magnitude of the physiological and craving response to alcohol cues while in treatment and the degree of alcohol-cue exposure in patients' natural environment was assessed. Physiological reactivity and craving in response to experimental exposure to alcohol and soft drink advertisements were measured during detoxification treatment using heart rate variability and subjective rating of craving. Following discharge, patients monitored exposure to alcohol advertisements for five consecutive weeks with a diary and were followed up with an assessment of relapse at 5 weeks and 3 months post-discharge. The results indicated that the presence of alcohol cues such as the portrayal of the drug and drinking behaviour induced physiological cue reactivity and craving. Additionally, cue reactivity and craving were positively correlated, and cue reactivity was larger for patients with shorter histories of alcohol dependence. Further, patients reported a substantial daily exposure to alcohol cues. The magnitude of cue reactivity and the craving response to alcohol cues at baseline and degree of exposure to alcohol cues in patients' natural environment did not predict relapse. It is concluded that the presence of alcohol cues such as portrayal of alcoholic beverages and drinking behaviour induces cue reactivity and craving in alcohol dependence through a conditioned appetitive response.

Blunted feelings: alexithymia is associated with a diminished neural response to speech prosody.

How we perceive emotional signals from our environment depends on our personality. Alexithymia, a personality trait characterized by difficulties in emotion regulation has been linked to aberrant brain activity for visual emotional processing. Whether alexithymia also affects the brain's perception of emotional speech prosody is currently unknown. We used functional magnetic resonance imaging to investigate the impact of alexithymia on hemodynamic activity of three a priori regions of the prosody network: the superior temporal gyrus (STG), the inferior frontal gyrus and the amygdala. Twenty-two subjects performed an explicit task (emotional prosody categorization) and an implicit task (metrical stress evaluation) on the same prosodic stimuli. Irrespective of task, alexithymia was associated with a blunted response of the right STG and the bilateral amygdalae to angry, surprised and neutral prosody. Individuals with difficulty describing feelings deactivated the left STG and the bilateral amygdalae to a lesser extent in response to angry compared with neutral prosody, suggesting that they perceived angry prosody as relatively more salient than neutral prosody. In conclusion, alexithymia may be associated with a generally blunted neural response to speech prosody. Such restricted prosodic processing may contribute to problems in social communication associated with this personality trait.

Hearing feelings: a quantitative meta-analysis on the neuroimaging literature of emotional prosody perception.

With the advent of neuroimaging considerable progress has been made in uncovering the neural network involved in the perception of emotional prosody. However, the exact neuroanatomical underpinnings of the emotional prosody perception process remain unclear. Furthermore, it is unclear what the intrahemispheric basis might be of the relative right-hemispheric specialization for emotional prosody perception that has been found previously in the lesion literature. In an attempt to shed light on these issues, quantitative meta-analyses of the neuroimaging literature were performed to investigate which brain areas are robustly associated with stimulus-driven and task-dependent perception of emotional prosody. Also, lateralization analyses were performed to investigate whether statistically reliable hemispheric specialization across studies can be found in these networks. A bilateral temporofrontal network was found to be implicated in emotional prosody perception, generally supporting previously proposed models of emotional prosody perception. Right-lateralized convergence across studies was found in (early) auditory processing areas, suggesting that the right hemispheric specialization for emotional prosody perception reported previously in the lesion literature might be driven by hemispheric specialization for non-prosody-specific fundamental acoustic dimensions of the speech signal.

Hearing feelings: affective categorization of music and speech in alexithymia, an ERP study.

BACKGROUND: Alexithymia, a condition characterized by deficits in interpreting and regulating feelings, is a risk factor for a variety of psychiatric conditions. Little is known about how alexithymia influences the processing of emotions in music and speech. Appreciation of such emotional qualities in auditory material is fundamental to human experience and has profound consequences for functioning in daily life. We investigated the neural signature of such emotional processing in alexithymia by means of event-related potentials. METHODOLOGY: Affective music and speech prosody were presented as targets following affectively congruent or incongruent visual word primes in two conditions. In two further conditions, affective music and speech prosody served as primes and visually presented words with affective connotations were presented as targets. Thirty-two participants (16 male) judged the affective valence of the targets. We tested the influence of alexithymia on cross-modal affective priming and on N400 amplitudes, indicative of individual sensitivity to an affective mismatch between words, prosody, and music. Our results indicate that the affective priming effect for prosody targets tended to be reduced with increasing scores on alexithymia, while no behavioral differences were observed for music and word targets. At the electrophysiological level, alexithymia was associated with significantly smaller N400 amplitudes in response to affectively incongruent music and speech targets, but not to incongruent word targets. CONCLUSIONS: Our results suggest a reduced sensitivity for the emotional qualities of speech and music in alexithymia during affective categorization. This deficit becomes evident primarily in situations in which a verbalization of emotional information is required.

The nature of hemispheric specialization for linguistic and emotional prosodic perception: a meta-analysis of the lesion literature.

It is unclear whether there is hemispheric specialization for prosodic perception and, if so, what the nature of this hemispheric asymmetry is. Using the lesion-approach, many studies have attempted to test whether there is hemispheric specialization for emotional and linguistic prosodic perception by examining the impact of left vs. right hemispheric damage on prosodic perception task performance. However, so far no consensus has been reached. In an attempt to find a consistent pattern of lateralization for prosodic perception, a meta-analysis was performed on 38 lesion studies (including 450 left hemisphere damaged patients, 534 right hemisphere damaged patients and 491 controls) of prosodic perception. It was found that both left and right hemispheric damage compromise emotional and linguistic prosodic perception task performance. Furthermore, right hemispheric damage degraded emotional prosodic perception more than left hemispheric damage (trimmed g=-0.37, 95% CI [-0.66; -0.09], N=620 patients). It is concluded that prosodic perception is under bihemispheric control with relative specialization of the right hemisphere for emotional prosodic perception.