RESUMO
GUIDELINE OBJECTIVES: These guidelines aim to enhance patient care by optimizing the diagnosis and treatment of infections due to creeping disease (cutaneous larva migrans) and to raise awareness among doctors of current treatment options. METHODS: S1 guideline, non-systematic literature search, consensus process using a circular letter.
Assuntos
Albendazol/administração & dosagem , Antinematódeos/administração & dosagem , Dermatologia/normas , Ivermectina/administração & dosagem , Larva Migrans/diagnóstico , Larva Migrans/tratamento farmacológico , Guias de Prática Clínica como Assunto , Administração Oral , Administração Tópica , Relação Dose-Resposta a Droga , Alemanha , Humanos , Larva Migrans/parasitologia , Larva Migrans/patologiaRESUMO
There are many anatomical and functional differences between the skin of young children and adult skin. As a consequence, the skin is more easily irritated by topical agents. There is also increased transcutaneous absorption; the latter effect is amplified by underlying conditions such as ichthyoses and atopic dermatitis with defects of the epidermal barrier. Common topical agents such as salicylic acid and lactic acid can cause life-threatening intoxications. The relevance of transcutaneous absorption of "hidden" ingredients such as polyethylene glycol and preservatives is unknown at present. By emulsifying endogenous barrier lipids, emulsifiers can promote skin dryness. We review the effects of common emollients and their suitability for skin care in children, particularly with the aim to reduce exposure to potential contact allergens and inadvertent emollient activity.
Assuntos
Toxidermias/etiologia , Toxidermias/prevenção & controle , Emolientes/administração & dosagem , Emolientes/efeitos adversos , Hipersensibilidade/prevenção & controle , Ictiose/induzido quimicamente , Ictiose/prevenção & controle , Veículos Farmacêuticos/efeitos adversos , Criança , Fármacos Dermatológicos/efeitos adversos , HumanosRESUMO
A total of 7.4 wt % of hydrogen was released from the mixture of magnesium amide and magnesium hydride at a molar ratio of 1:2 by mechanical ball milling. Fourier Transform Infrared Spectroscopy (FTIR) and X-ray Diffraction (XRD) characterizations along with the amount of hydrogen released at different stages of ball milling reveal that magnesium imide was first formed in the reaction. The imide then reacted continuously with magnesium hydride and was converted to magnesium nitride and hydrogen. Thermodynamic calculation shows that the hydrogen desorption is a mild endothermic reaction with the standard enthalpy change of about 3.5 kJ/mol of H2.