Detalhe da pesquisa
1.
Review of the Technical, Toxicological, and PKPD Considerations for Conducting Inhalation Toxicity Studies on Biologic Pharmaceuticals-The Outcome of a Cross-Industry Working Group Survey.
Toxicol Pathol
; 49(2): 261-285, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33535023
2.
BSTP Review of 12 Case Studies Discussing the Challenges, Pathology, Immunogenicity, and Mechanisms of Inhaled Biologics.
Toxicol Pathol
; 49(2): 235-260, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33455525
3.
The use of emerging safety biomarkers in nonclinical and clinical safety assessment - The current and future state: An IQ DruSafe industry survey.
Regul Toxicol Pharmacol
; 120: 104857, 2021 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-33387566
4.
Nonclinical cardiovascular safety evaluation of romosozumab, an inhibitor of sclerostin for the treatment of osteoporosis in postmenopausal women at high risk of fracture.
Regul Toxicol Pharmacol
; 115: 104697, 2020 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-32590049
5.
Opportunities for use of one species for longer-term toxicology testing during drug development: A cross-industry evaluation.
Regul Toxicol Pharmacol
; 113: 104624, 2020 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-32126256
6.
Optimized nonclinical safety assessment strategies supporting clinical development of therapeutic monoclonal antibodies targeting inflammatory diseases.
Drug Dev Res
; 75(3): 115-61, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24782266
7.
Sclerostin Downregulation Globally by Naturally Occurring Genetic Variants, or Locally in Atherosclerotic Plaques, Does Not Associate With Cardiovascular Events in Humans.
J Bone Miner Res
; 36(7): 1326-1339, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33784435
8.
Justification for species selection for pharmaceutical toxicity studies.
Toxicol Res (Camb)
; 9(6): 758-770, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-33442468
9.
Optimization of the comet assay for the sensitive detection of PUVA-induced DNA interstrand cross-links.
Mutagenesis
; 24(2): 173-81, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19147795
10.
Identification of a Novel Allosteric Inhibitory Site on Tryptophan Hydroxylase 1 Enabling Unprecedented Selectivity Over all Related Hydroxylases.
Front Pharmacol
; 8: 240, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28529483
11.
Challenges for inhaled drug discovery and development: Induced alveolar macrophage responses.
Adv Drug Deliv Rev
; 71: 15-33, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24530633
12.
Association of gene expression with sequential proliferation, differentiation and tumor formation in murine skin.
Carcinogenesis
; 27(8): 1556-66, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16537558