Detalhe da pesquisa
1.
Effect of Food and a Proton-Pump Inhibitor on the Absorption of Encorafenib: An In Vivo-In Vitro-In Silico Approach.
Mol Pharm
; 20(5): 2589-2599, 2023 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37037186
2.
Immobilized Cytochrome P450 for Monitoring of P450-P450 Interactions and Metabolism.
Drug Metab Dispos
; 44(5): 741-9, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26961240
3.
Evaluation of the effect of modafinil on the pharmacokinetics of encorafenib and binimetinib in patients with BRAF V600-mutant advanced solid tumors.
Cancer Chemother Pharmacol
; 2024 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38878209
4.
Clinical Evaluation of the Effect of Encorafenib on Bupropion, Rosuvastatin, and Coproporphyrin I and Considerations for Statin Coadministration.
Clin Pharmacokinet
; 63(4): 483-496, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38424308
5.
Measurement of electron transfer through cytochrome P450 protein on nanopillars and the effect of bound substrates.
J Am Chem Soc
; 135(10): 3834-40, 2013 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23427827
6.
Pharmacodynamic variability beyond that explained by MICs.
Antimicrob Agents Chemother
; 57(4): 1730-5, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23357773
7.
Pharmacokinetic simulation of fatal carbamazepine intoxication in 23-month old child following phenytoin discontinuation.
Forensic Sci Med Pathol
; 9(1): 73-6, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22915321
8.
A phase I, single-center, open-label study to investigate the absorption, distribution, metabolism and excretion of encorafenib following a single oral dose of 100 mg [14 C] encorafenib in healthy male subjects.
Pharmacol Res Perspect
; 11(5): e01140, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37775918
9.
Impact of posaconazole and diltiazem on pharmacokinetics of encorafenib, a BRAF V600 kinase inhibitor for melanoma and colorectal cancer with BRAF mutations.
Clin Transl Sci
; 16(12): 2675-2686, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37837178
10.
Selective filling of nanowells in nanowell arrays fabricated using polystyrene nanosphere lithography with cytochrome P450 enzymes.
Nanotechnology
; 23(38): 385101, 2012 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-22947619
11.
A Phase Ib/II Study of the BRAF Inhibitor Encorafenib Plus the MEK Inhibitor Binimetinib in Patients with BRAFV600E/K -mutant Solid Tumors.
Clin Cancer Res
; 26(19): 5102-5112, 2020 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32669376
12.
Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer.
J Med Chem
; 63(13): 6679-6693, 2020 07 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32250617
13.
Electrocatalytic drug metabolism by CYP2C9 bonded to a self-assembled monolayer-modified electrode.
Drug Metab Dispos
; 37(4): 892-9, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19171677
14.
A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors.
Cancer Discov
; 7(9): 963-972, 2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28578312
15.
Pexmetinib: A Novel Dual Inhibitor of Tie2 and p38 MAPK with Efficacy in Preclinical Models of Myelodysplastic Syndromes and Acute Myeloid Leukemia.
Cancer Res
; 76(16): 4841-4849, 2016 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27287719
16.
An exploratory, randomized, parallel-group, open-label, relative bioavailability study with an additional two-period crossover food-effect study exploring the pharmacokinetics of two novel formulations of pexmetinib (ARRY-614).
Clin Pharmacol
; 7: 87-95, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26491375
17.
The use of immobilized cytochrome P4502C9 in PMMA-based plug flow bioreactors for the production of drug metabolites.
Appl Biochem Biotechnol
; 172(3): 1293-306, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24166101
18.
Esterase activities in the blood, liver and intestine of several preclinical species and humans.
Drug Metab Lett
; 3(2): 70-7, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19601867
19.
Self-organized honeycomb structures of Mn(12) single-molecule magnets.
J Phys Chem B
; 113(44): 14674-80, 2009 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-19824615