Detalhe da pesquisa
1.
The discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors.
Bioorg Med Chem Lett
; 26(11): 2622-6, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27106708
2.
Structure-activity-relationship of amide and sulfonamide analogs of omarigliptin.
Bioorg Med Chem Lett
; 25(24): 5767-71, 2015 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26546218
3.
Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: Profile of clinical candidate (2R,3S,5R)-2- (2,5-difluorophenyl)-5-(4,6-dihydropyrrolo [3,4-c]pyrazol-5-(1H)-yl)tetrahydro-2H-pyran-3-amine (23) [corrected].
Bioorg Med Chem Lett
; 23(19): 5361-6, 2013 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23972441
4.
Synthesis and evaluation of [(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexanes and 4-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]piperidines as DPP-4 inhibitors.
Bioorg Med Chem Lett
; 21(6): 1880-6, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21320777
5.
Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors.
Bioorg Med Chem Lett
; 19(15): 4097-101, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19539471
6.
Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines.
J Med Chem
; 51(3): 589-602, 2008 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-18201067
7.
Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors.
Bioorg Med Chem Lett
; 18(7): 2409-13, 2008 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18331795
8.
A comparative study of the binding properties, dipeptidyl peptidase-4 (DPP-4) inhibitory activity and glucose-lowering efficacy of the DPP-4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice.
Endocrinol Diabetes Metab
; 1(1): e00002, 2018 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-30815539
9.
Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9.
Diabetes
; 54(10): 2988-94, 2005 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-16186403
10.
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
J Med Chem
; 49(12): 3614-27, 2006 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16759103
11.
(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
J Med Chem
; 48(1): 141-51, 2005 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-15634008
12.
Modeling assisted rational design of novel, potent, and selective pyrrolopyrimidine DPP-4 inhibitors.
Bioorg Med Chem Lett
; 17(14): 3877-9, 2007 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17502141
13.
Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes.
Bioorg Med Chem Lett
; 17(21): 5853-7, 2007 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17869513
14.
4-aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV.
Bioorg Med Chem Lett
; 17(10): 2879-85, 2007 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17350841
15.
Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors.
Bioorg Med Chem Lett
; 17(16): 4579-83, 2007 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17562364
16.
Triazolopiperazine-amides as dipeptidyl peptidase IV inhibitors: close analogs of JANUVIA (sitagliptin phosphate).
Bioorg Med Chem Lett
; 17(12): 3373-7, 2007 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17434732
17.
4-arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV.
Bioorg Med Chem Lett
; 17(21): 5806-11, 2007 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17851076
18.
Design, synthesis, and biological evaluation of triazolopiperazine-based beta-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors.
Bioorg Med Chem Lett
; 17(21): 5934-9, 2007 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17827003
19.
Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors.
Bioorg Med Chem Lett
; 16(5): 1346-9, 2006 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16332437
20.
Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors.
Bioorg Med Chem Lett
; 16(20): 5373-7, 2006 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16919457