Detalhe da pesquisa
1.
Pharmacokinetics and safety of EVER206, a novel polymyxin antimicrobial, in healthy Chinese subjects.
Antimicrob Agents Chemother
; : e0156323, 2024 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38647294
2.
First-in-human study to evaluate the safety, tolerability, and population pharmacokinetic/pharmacodynamic target attainment analysis of FL058 alone and in combination with meropenem in healthy subjects.
Antimicrob Agents Chemother
; 68(1): e0133023, 2024 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38054726
3.
A phase I study of the safety, tolerability, and pharmacokinetics of contezolid acefosamil after intravenous and oral administration in healthy Chinese subjects.
Antimicrob Agents Chemother
; 67(11): e0079623, 2023 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37902402
4.
Clinical Pharmacology and Utility of Contezolid in Chinese Patients with Complicated Skin and Soft-Tissue Infections.
Antimicrob Agents Chemother
; 66(6): e0243021, 2022 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35575579
5.
Pharmacokinetics of benapenem for injection in subjects with mild to moderate renal impairment.
Eur J Clin Pharmacol
; 78(7): 1079-1086, 2022 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-35385974
6.
Pharmacokinetics and Disposition of Contezolid in Humans: Resolution of a Disproportionate Human Metabolite for Clinical Development.
Antimicrob Agents Chemother
; 65(11): e0040921, 2021 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34398672
7.
Tolerability, Safety, Pharmacokinetics, and Immunogenicity of a Novel SARS-CoV-2 Neutralizing Antibody, Etesevimab, in Chinese Healthy Adults: a Randomized, Double-Blind, Placebo-Controlled, First-in-Human Phase 1 Study.
Antimicrob Agents Chemother
; 65(8): e0035021, 2021 07 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33972256
8.
Nemonoxacin dosage adjustment in patients with severe renal impairment based on population pharmacokinetic and pharmacodynamic analysis.
Br J Clin Pharmacol
; 87(12): 4636-4647, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33928669
9.
Effects of Different Component Contents of Colistin Methanesulfonate on the Pharmacokinetics of Prodrug and Formed Colistin in Human.
Pharm Res
; 38(1): 79-87, 2021 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-33496870
10.
Evaluation of the Effect of Contezolid (MRX-I) on the Corrected QT Interval in a Randomized, Double-Blind, Placebo- and Positive-Controlled Crossover Study in Healthy Chinese Volunteers.
Antimicrob Agents Chemother
; 64(6)2020 05 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32229495
11.
Clinical efficacy and safety of polymyxins based versus non-polymyxins based therapies in the infections caused by carbapenem-resistant Acinetobacter baumannii: a systematic review and meta-analysis.
BMC Infect Dis
; 20(1): 296, 2020 Apr 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32316926
12.
A Prospective Multicenter Clinical Observational Study on Vancomycin Efficiency and Safety With Therapeutic Drug Monitoring.
Clin Infect Dis
; 67(suppl_2): S249-S255, 2018 11 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30423040
13.
Model-based Evaluation of the Clinical and Microbiological Efficacy of Vancomycin: A Prospective Study of Chinese Adult In-house Patients.
Clin Infect Dis
; 67(suppl_2): S256-S262, 2018 11 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30423042
14.
Population Pharmacokinetics and Dosing Regimen Optimization of Meropenem in Cerebrospinal Fluid and Plasma in Patients with Meningitis after Neurosurgery.
Antimicrob Agents Chemother
; 60(11): 6619-6625, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27572392
15.
Pharmacokinetics and pharmacodynamics of multiple-dose intravenous nemonoxacin in healthy Chinese volunteers.
Antimicrob Agents Chemother
; 59(3): 1446-54, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25534726
16.
Safety, tolerability, and pharmacokinetics of intravenous nemonoxacin in healthy chinese volunteers.
Antimicrob Agents Chemother
; 58(10): 6116-21, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25092690
17.
Pharmacokinetic and safety profiles of mesalazine enema in healthy Chinese subjects: A single- and multiple-dose study.
PLoS One
; 19(2): e0296940, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38306390
18.
Age-Related Differences in Vancomycin-Associated Nephrotoxicity and Efficacy in Methicillin-Resistant Staphylococcus aureus Infection: A Comparative Study between Elderly and Adult Patients.
Antibiotics (Basel)
; 13(4)2024 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38667000
19.
Dose adjustment not required for contezolid in patients with moderate hepatic impairment based on pharmacokinetic/pharmacodynamic analysis.
Front Pharmacol
; 14: 1135007, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36992830
20.
Safety, Tolerability and Pharmacokinetics of Single and Multiple Doses of Mirogabalin in Healthy Chinese Participants: A Randomized, Double-Blind, Placebo-Controlled Study.
Adv Ther
; 40(4): 1628-1643, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36790683