Detalhe da pesquisa
1.
Targeting phosphodiesterase 4 as a therapeutic strategy for cognitive improvement.
Bioorg Chem
; 130: 106278, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36413930
2.
Recent advances in targeting leucine-rich repeat kinase 2 as a potential strategy for the treatment of Parkinson's disease.
Bioorg Chem
; 141: 106906, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37837728
3.
Design, synthesis, biological evaluation and molecular modeling of N-isobutyl-N-((2-(p-tolyloxymethyl)thiazol-4yl)methyl)benzo[d][1,3] dioxole-5-carboxamides as selective butyrylcholinesterase inhibitors.
Bioorg Med Chem Lett
; 61: 128602, 2022 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35124202
4.
N'-[(3-[benzyloxy]benzylidene]-3,4,5-trihydroxybenzohydrazide (1) protects mice against colitis induced by dextran sulfate sodium through inhibiting NFκB/IL-6/STAT3 pathway.
Biochem Biophys Res Commun
; 477(2): 290-6, 2016 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27311853
5.
Development of hydroxy-based sphingosine kinase inhibitors and anti-inflammation in dextran sodium sulfate induced colitis in mice.
Bioorg Med Chem
; 24(14): 3218-30, 2016 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27255176
6.
Synthesis, identification, and biological activity of metabolites of two novel selective S1P1 agonists.
Bioorg Med Chem
; 24(10): 2273-9, 2016 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27068143
7.
Effective screening strategy using ensembled pharmacophore models combined with cascade docking: application to p53-MDM2 interaction inhibitors.
J Chem Inf Model
; 53(10): 2715-29, 2013 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-24050442
8.
Therapeutic potential of targeting kynurenine pathway in neurodegenerative diseases.
Eur J Med Chem
; 251: 115258, 2023 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36917881
9.
Hyaluronic Acid Poly(glyceryl)10-Stearate Derivatives: Novel Emulsifiers for Improving the Gastrointestinal Stability and Bioaccessibility of Coenzyme Q10 Nanoemulsions.
J Agric Food Chem
; 71(29): 11180-11194, 2023 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37436914
10.
Therapeutic potential of phosphodiesterase inhibitors for cognitive amelioration in Alzheimer's disease.
Eur J Med Chem
; 232: 114170, 2022 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35144038
11.
Therapeutic potential of targeting SHP2 in human developmental disorders and cancers.
Eur J Med Chem
; 190: 112117, 2020 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32061959
12.
CDK8 as a therapeutic target for cancers and recent developments in discovery of CDK8 inhibitors.
Eur J Med Chem
; 164: 77-91, 2019 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30594029
13.
Small molecule PROTACs in targeted therapy: An emerging strategy to induce protein degradation.
Eur J Med Chem
; 174: 159-180, 2019 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31035238
14.
Assessing the ligand selectivity of sphingosine kinases using molecular dynamics and MM-PBSA binding free energy calculations.
Mol Biosyst
; 12(4): 1174-82, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26927311
15.
Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure-Activity Relationship Study.
J Med Chem
; 58(14): 5419-36, 2015 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-26111355
16.
Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis.
J Med Chem
; 57(6): 2736-45, 2014 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24512214
17.
Insight into the intermolecular recognition mechanism between Keap1 and IKKß combining homology modelling, protein-protein docking, molecular dynamics simulations and virtual alanine mutation.
PLoS One
; 8(9): e75076, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24066166
18.
3-aroylmethylene-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-ones as potent Nrf2/ARE inducers in human cancer cells and AOM-DSS treated mice.
J Med Chem
; 56(20): 7925-38, 2013 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24053646
19.
Synthesis and bioevaluation of a series of α-pyrone derivatives as potent activators of Nrf2/ARE pathway (part I).
Eur J Med Chem
; 66: 364-71, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23820128
20.
Synthesis, SAR and biological evaluation of natural and non-natural hydroxylated and prenylated xanthones as antitumor agents.
Med Chem
; 8(6): 1012-25, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22779801