Magnetostrictive current sensor with high sensitivity and a large linear range for the subway.

Stray current affects the safe operation of subway equipment. The stray current leakage point can be located by measuring the current of subway running track. A magnetostrictive current sensor with high sensitivity and a large linear range is proposed to monitor track current. The design of the sensor is qualitatively guided by a set of finite element method (FEM) simulations to improve the sensitivity of the sensor. However, when the sensitivity of the sensor increases, the linear range decreases. To solve this problem, a novel current sensor, to the best of our knowledge, which is composed of magnetostrictive composites, steel bars, and adjustable coils, is presented. The linear range of the sensor is expanded by adjusting the different DC bias magnetic fields generated by the adjustable coils. The results show that when the measured current is 0-500 A and 500-1000 A, the Terfenol-D (TD) mass is only 0.14 g, and the sensitivity of the sensor is 0.391 µÉ›/A and 0.418 µÉ›/A, respectively. The current measurement with low cost, high sensitivity, and larger linear working range is realized, which is suitable for monitoring stray current leakage points.

EML4-ALK, a potential therapeutic target that responds to alectinib in ovarian cancer.

Ovarian cancer is prone to recurrence and chemotherapy resistance. Ovarian tumours of some patients have been positive for anaplastic lymphoma kinase fusion gene expression (ALK+). Preclinical studies indicate that anaplastic lymphoma kinase inhibitor can suppress the growth of ovarian cancer cells and transplantation tumours. Here, we present a patient with metastatic ALK+ high-grade serous ovarian cancer that testing positive for EML4-ALK (microtubule-associated protein-like 4 gene, fused to the anaplastic lymphoma kinase gene), experienced dramatic benefit after administration of the anaplastic lymphoma kinase inhibitor alectinib. This is the first clinical evidence that treatment with alectinib may provide a personalized maximum benefit for patients with high-grade serous ovarian cancer who are positive for EML4-ALK.

Intrathecal Drug Delivery and Spinal Cord Stimulation for the Treatment of Cancer Pain.

PURPOSE OF REVIEW: The purpose of the present investigation is to summarize the body and quality of evidence including the most recent studies in support of intrathecal drug delivery systems and spinal cord stimulation for the treatment of cancer-related pain. RECENT FINDINGS: In the past 3 years, a number of prospective studies have been published supporting intrathecal drug delivery systems for cancer pain. Additional investigation with adjuvants to morphine-based analgesia including dexmedetomidine and ziconotide support drug-induced benefits of patient-controlled intrathecal analgesia. A study has also been recently published regarding cost-savings for intrathecal drug delivery system compared to pharmacologic management, but an analysis in the Ontario, Canada healthcare system projects additional financial costs. Finally, the Polyanalgesic Consensus Committee has updated its recommendations regarding clinical guidelines for intrathecal drug delivery systems to include new information on dosing, trialing, safety, and systemic opioid reduction. There is still a paucity of clinical evidence for spinal cord stimulation in the treatment of cancer pain. There are new intrathecal drugs under investigation including various conopeptides and AYX1. Large, prospective, modern, randomized controlled studies are still needed to support the use of both intrathecal drug delivery systems as well as spinal cord stimulation for cancer pain populations. There are multiple prospective and small randomized controlled studies that highlight a potential promising future for these interventional modalities. Related to the challenge and urgency of cancer pain, the pain practitioner community is moving toward a multimodal approach that includes discussions regarding the role of intrathecal therapies and spinal cord stimulation to the individualized treatment of patients.

An Elimination Method of Temperature-Induced Linear Birefringence in a Stray Current Sensor.

In this work, an elimination method of the temperature-induced linear birefringence (TILB) in a stray current sensor is proposed using the cylindrical spiral fiber (CSF), which produces a large amount of circular birefringence to eliminate the TILB based on geometric rotation effect. First, the differential equations that indicate the polarization evolution of the CSF element are derived, and the output error model is built based on the Jones matrix calculus. Then, an accurate search method is proposed to obtain the key parameters of the CSF, including the length of the cylindrical silica rod and the number of the curve spirals. The optimized results are 302 mm and 11, respectively. Moreover, an effective factor is proposed to analyze the elimination of the TILB, which should be greater than 7.42 to achieve the output error requirement that is not greater than 0.5%. Finally, temperature experiments are conducted to verify the feasibility of the elimination method. The results indicate that the output error caused by the TILB can be controlled less than 0.43% based on this elimination method within the range from -20 °C to 40 °C.

A Linear Birefringence Measurement Method for an Optical Fiber Current Sensor.

In this work, a linear birefringence measurement method is proposed for an optical fiber current sensor (OFCS). First, the optical configuration of the measurement system is presented. Then, the elimination method of the effect of the azimuth angles between the sensing fiber and the two polarizers is demonstrated. Moreover, the relationship of the linear birefringence, the Faraday rotation angle and the final output is determined. On these bases, the multi-valued problem on the linear birefringence is simulated and its solution is illustrated when the linear birefringence is unknown. Finally, the experiments are conducted to prove the feasibility of the proposed method. When the numbers of turns of the sensing fiber in the OFCS are about 15, 19, 23, 27, 31, 35, and 39, the measured linear birefringence obtained by the proposed method are about 1.3577, 1.8425, 2.0983, 2.5914, 2.7891, 3.2003 and 3.5198 rad. Two typical methods provide the references for the proposed method. The proposed method is proven to be suitable for the linear birefringence measurement in the full range without the limitation that the linear birefringence must be smaller than π/2.

Polarimetric current sensor based on polarization division multiplexing detection.

A polarimetric current sensor based on polarization division multiplexing (PDM) detection is proposed. The novel sensor head with a heat insulation cavity only induces a small level of birefringence. Comparing with polarization diversity (PD) detection, the sensitivity of PDM detection is the double of PD detection. Moreover, PDM detection is more suitable in the presence of the phase modulation error. In addition, the noise and the shifting of the Verdet constant are proved to be the main influence factors of the sensor performance as the source power decline.

Effect and elimination of alignment error in an optical fiber current sensor.

This Letter demonstrates the effect and elimination of alignment error in an optical fiber current sensor. An optical model is built to illustrate the effect of alignment error, which does not induce zero drift and has a large effect on output accuracy. The total alignment error and modulation angle of the polarization controller are defined as k and θ, respectively. Parameter t is equal to 2θ-2k. An elimination method of the error k is proposed, which corrects the angle θ to keep parameter t at 90 deg. This method avoids the measurement of all splice angles separately. Its feasibility is shown by simulation results. In addition, the measurement method and conditions of parameter t are presented. The final t is about 90.24 deg. Furthermore, the effectiveness of the proposed elimination method is proven by a performance test.

Stray current sensor with cylindrical twisted fiber.

In this paper, a stray current sensor with cylindrical twisted fiber is proposed. The quantitative method of linear birefringence on the sensing fiber is demonstrated. And the temperature-induced linear birefringence is about 4.63 deg per meter at 60 deg centigrade. Then, the demand of circular birefringence is determined based on the polarization division multiplexing model, which is produced by the cylindrical twisted fiber. According to the simulation results, the produced circular birefringence is about 2116.9 deg, which is enough to suppress the linear birefringence. The temperature experiment results indicate the positive effect of the cylindrical twisted fiber, which controls the linear birefringence error within 0.945×10(-5) per degree centigrade. Finally, the performance test results prove the cylindrical twisted fiber improves the accuracy of the stray current sensor. And its repeatability and sensitivity are about 0.367% and 0.0261/A, respectively.

Viologen-based solution-processable ionic porous polymers for electrochromic applications.

Electrochromic porous thin films are promising for applications in smart windows and energy-efficient optical displays. However, their generally poor processing ability and excessive processing times remain grand challenges. Herein, we report the design and convenient synthesis of core-altered N-arylated viologens with aldehyde groups (πV-CHO) as new building blocks to prepare soluble, viologen-embedded ionic porous polymers. We also demonstrate that these polymers can be easily solution-processed by drop-coating to fabricate high-quality electrochromic films with tunable optoelectronic properties in a cost-effective fashion. The prepared films exhibit excellent electrochromic performance, including a low driving voltage (1.2-1.4 V), fast switching times (0.8-1.7 s), great coloration efficiency (73-268 cm2 C-1), remarkably high optical contrast up to 95.6%, long cycling stability, and tunable oxidation and reduction colors. This work sheds important light on a new molecular engineering approach to produce redox-active polymers with combined properties of intrinsic porosity, reversible and tunable redox activity, and solution processability. This provides the materials with an inherently broad utility in a variety of electrochemical devices for energy storage, sensors, and electronic applications.

Cross-linking enhances the performance of four-electron carbonylpyridinium based polymers for lithium organic batteries.

Design and integration of multiple redox-active organic scaffolds into tailored polymer structures to enhance the specific capacity and cycling life is a long-term research goal. Inspired by nature, we designed and incorporated a 4-electron accepting dicarbonylpyridinium redox motif into linear (DBMP) and cross-linked polymer (TBMP) structures. Benefiting from the suppressed solubility and higher electronic conductivity, the cross-linked TBMP based electrode exhibits improved cycling stability and higher specific capacity than the linear counterpart. After 4000 cycles at 1 A g-1, TBMP can maintain a high capacity of 252 mA h g-1, surpassing the performance of many reported organic cathodes. The structural evolution and reaction kinetics during charge and discharge have been investigated in detail. This study demonstrates that cross-linking is an effective strategy to push the bio-derived carbonylpyridinium materials for high performance LOBs.

An integrated approach to elucidate the intra-viral and viral-cellular protein interaction networks of a gamma-herpesvirus.

Genome-wide yeast two-hybrid (Y2H) screens were conducted to elucidate the molecular functions of open reading frames (ORFs) encoded by murine γ-herpesvirus 68 (MHV-68). A library of 84 MHV-68 genes and gene fragments was generated in a Gateway entry plasmid and transferred to Y2H vectors. All possible pair-wise interactions between viral proteins were tested in the Y2H assay, resulting in the identification of 23 intra-viral protein-protein interactions (PPIs). Seventy percent of the interactions between viral proteins were confirmed by co-immunoprecipitation experiments. To systematically investigate virus-cellular protein interactions, the MHV-68 Y2H constructs were screened against a cellular cDNA library, yielding 243 viral-cellular PPIs involving 197 distinct cellar proteins. Network analyses indicated that cellular proteins targeted by MHV-68 had more partners in the cellular PPI network and were located closer to each other than expected by chance. Taking advantage of this observation, we scored the cellular proteins based on their network distances from other MHV-68-interacting proteins and segregated them into high (Y2H-HP) and low priority/not-scored (Y2H-LP/NS) groups. Significantly more genes from Y2H-HP altered MHV-68 replication when their expression was inhibited with siRNAs (53% of genes from Y2H-HP, 21% of genes from Y2H-LP/NS, and 16% of genes randomly chosen from the human PPI network; p<0.05). Enriched Gene Ontology (GO) terms in the Y2H-HP group included regulation of apoptosis, protein kinase cascade, post-translational protein modification, transcription from RNA polymerase II promoter, and IκB kinase/NFκB cascade. Functional validation assays indicated that PCBP1, which interacted with MHV-68 ORF34, may be involved in regulating late virus gene expression in a manner consistent with the effects of its viral interacting partner. Our study integrated Y2H screening with multiple functional validation approaches to create γ-herpes viral-viral and viral-cellular protein interaction networks.

Construction of Naphthalene Diimide Derived Nanostructured Cathodes through Self-Assembly for High-Performance Sodium-Organic Batteries.

Organic nanostructured electrodes are very attractive for next-generation sodium-ion batteries. Their great advantages in improved electron and ion transport and more exposed redox-active sites would lead to a higher actual capacity and enhanced rate performance. However, facile and cost-effective methods for the fabrication of nanostructured organic electrodes are still highly challenging and very rare. In this work, we utilize a bioinspired self-assembly strategy to fabricate nanostructured cathodes based on a rationally designed N-hydroxy naphthalene imide sodium salt (NDI-ONa) for high-performance sodium-organic batteries. Such a well-organized nanostructure can greatly enhance both ion and electron transport. When used as cathode for sodium-organic batteries, it provides among the best battery performances, such as high capacity (171 mA h g-1 at 0.05 A g-1), excellent rate performance (153 mA h g-1 at 5.0 A g-1), and ultralong cycling life (93% capacity retention after 20000 cycles at 3.0 A g-1). Even at low temperature or without a conductive additive, it can also perform well. It is believed that self-assembly is a very powerful strategy to construct high-performance nanostructured electrodes.

Competition for Light Interception in Different Plant Canopy Characteristics of Diverse Cotton Cultivars.

Identifying the ideal plant nature and canopy structure is of great importance for improving photosynthetic production and the potential action of plants. To address this challenge, an investigation was accomplished in 2018 and 2019 at the Institute of Cotton Research (ICR) of the Chinese Academy of Agricultural Science (CAAS), Henan Province, China. Six cotton varieties with diverse maturities and plant canopy structures were used to evaluate the light interception (LI) in cotton, the leaf area index (LAI), the biomass, and the yield throughout the two years of study. The light spatial distribution in the plant canopy was evaluated using a geographic statistical method, following the increasing quantity of radiation intercepted, which was determined using the rules of Simpson. Compared to the cotton plants with a compact structure, varieties with both a loose and tower design captured a comparatively higher amount of light (average 31.3%) and achieved a higher LAI (average 32.4%), eventually achieving a high yield (average 10.1%). Furthermore, the polynomial correlation revealed a positive relationship between the biomass accumulation in the reproductive parts and canopy-accrued light interception (LI), signifying that light interception is critical for the yield development of cotton. Furthermore, when the leaf area index (LAI) was peaked, radiation interception and biomass reached the highest during the boll-forming stage. These findings will provide guidance on the light distribution in cotton cultivars with an ideal plant structure for light capture development, providing an important foundation for researchers to better manage light and canopies.

[Effect of early rehabilitation exercise on blood pressure of elderly patients with septic shock: a single-center, prospective, randomized controlled study].

OBJECTIVE: To observe the effect of early rehabilitation exercise on blood pressure of elderly patients with septic shock. METHODS: A single-center, prospective, randomized controlled study was conducted in elderly patients with septic shock who were hospitalized in the department of critical care medicine of Huangshan Shoukang Hospital (High-tech Zone Central Hospital of Huangshan) from December 2018 to November 2020. According to the principle of simple random, all patients were divided into control group and intervention group. Both groups were treated with lower limb barometry to prevent deep vein thrombosis, 3 times a day, 30 minutes each time. After comprehensive treatment in the intensive care unit (ICU), the severity of patients was gradually improved, the hemodynamics was relatively stable, and the norepinephrine was reduced to 0.5 µg×kg-1×min-1. The control group continued to receive lower limb barometric treatment without rehabilitation training, while the intervention group began rehabilitation training when the dose of norepinephrine was reduced to 0.5 µg×kg-1×min-1. The duration of norepinephrine use, the length of ICU stay, and the occurrence of adverse events during rehabilitation training in intervention group was recorded. RESULTS: Seventy-two patients were included in the final analysis, 35 in intervention group and 37 in control group. There was no significant difference in gender, age, Oxford acute severity of illness score (OASIS), acute physiology and chronic health evaluation II (APACHE II), mean arterial pressure (MAP) of 3 times and underlying diseases between two groups. Compared with control group, the length of ICU stay and duration of dose of norepinephrine ≤ 0.5 µg×kg-1×min-1 in intervention group were significantly shorter [length of ICU stay (hours): 193.0 (145.5, 312.0) vs. 242.5 (180.0, 483.5), P < 0.05; duration of dose of norepinephrine ≤ 0.5 µg×kg-1×min-1 (hours): 120.0 (72.0, 144.0) vs. 144.5 (120.0, 192.0), Z = 2.976, P = 0.003]. In intervention group, 35 patients did not show acute myocardial infarction, arrhythmia, syncope, central venous catheter detachment, and gastric tube detachment during the rehabilitation period, except 1 patient suffered from naked hematuria due to urinary catheter traction, which disappeared the next day after symptomatic treatment. CONCLUSIONS: The early rehabilitation exercise was beneficial to the recovery of autonomic blood pressure in elderly patients with septic shock, shorten the time of norepinephrine use and ICU stay.

Serum Exosomes Derived from Irritable Bowel Syndrome Patient Increase Cell Permeability via Regulating miR-148b-5p/RGS2 Signaling in Human Colonic Epithelium Cells.

AIM: Irritable bowel syndrome (IBS) is a multifactorial functional bowel disorder characterized by disruption of the intestinal barrier. Circulating exosomal microRNAs (miRNAs) are involved in regulating epithelial barrier function, and upregulation of miR-148b-5p has been detected in IBS. However, whether exosomal miR-148-5p is involved in the IBS pathogenesis remains unclear. This study was aimed at investigating the relationship of exosomal miR-148-5p with colonic epithelial permeability. METHODS: Exosomes were isolated from the serum of IBS patients and healthy controls. HT-29 cells were cultured with the IBS-derived serum exosomes (IBS-exo). Exosome uptake assay was used to evaluate whether the IBS-exo could be absorbed by HT-29 cells. FITC-Dextran flux and transepithelial/endothelial electrical resistance were measured to evaluate epithelial permeability. A luciferase reporter assay was used to determine whether the regulator of G protein signaling- (RGS-) 2 is a target gene of miR-148b-5p. RESULTS: miR-148b-5p was obviously elevated in the IBS-exo compared to the control-exo. Upregulation of miR-148b-5p was observed in the HT-29 cells cultured with IBS-exo. Exposure to IBS-exo increased cell permeability and decreased RGS2 expression. The IBS-exo-induced alterations were obviously reversed by interfering with the miR-148b-5p expression. Mimicking the IBS-exo treatment, miR-148b-5p overexpression increased cell permeability and downregulated RGS2 expression, which were abrogated by overexpressing RGS2. The luciferase reporter assay revealed that RGS2 was a direct target of miR-148b-5p. CONCLUSIONS: Serum-derived exosomes from IBS patients increase colonic epithelial permeability via miR-148b-5p/RGS2 signaling.

Boll characteristics and yield of cotton in relation to the canopy microclimate under varying plant densities in an arid area.

Planting density affects crop microclimate and intra-plant competition, playing an important role on yield formation and resource use, especially in areas where the cotton is grown at relatively high plant densities in Xinjiang, China. However, more studies are needed to examine how the change in planting density affects the microclimate factors such as the fraction of light intercepted (FLI), air temperature(T) and relative humidity (RH) within different canopy layers, which in turn affect the boll number per plant (BNF), boll number per unit area (BNA), boll weight (BW), and boll-setting rate (BSR) at fruiting branch (FB) positions FB1-3, FB4-6, and FB≥7 in cotton. To quantify the relationships between boll characteristics, yield, and microclimate factors, we conducted a 2-year field experiment in 2019-2020 in Xinjiang with six plant densities: 9 (P1), 12 (P2), 15 (P3), 18 (P4), 21 (P5), and 24 (P6) plants m-2. With each three plants m-2 increase in density, the average FLI and RH across different canopy layers increased by 0.37 and 2.04%, respectively, whereas T decreased by 0.64 °C. The BNF at FB≥ 7, FB4-6, and FB1-3 decreased by 0.82, 0.33, and 0.5, respectively. The highest BNA was observed in the upper and middle layers in the P4 treatment and in the lowest canopy layer with the P5. The highest BW was measured in the middle canopy layer for P3, and the highest BSR was measured in the lower layer for P3. Plant density exhibited linear or quadratic relationships with FLI, T, and RH. Microclimate factors mainly affected the boll number in each layer, but had no significant effects on the BW in any layer or the BSR in the middle and lower layers. Cotton yield was non-linearly related to plant density. The 2-year maximum yield was achieved at a plant density of 21 plants m-2, but the yield increase compared to the yield with a density of 18 plants m-2was only 0.28%. Thus, we suggest that the optimal plant density for drip-irrigated cotton in Xinjiang is 18 plants m-2, which could help farmers grow machine-harvested cotton.

The American Society of Pain and Neuroscience (ASPN) Best Practices and Guidelines for the Interventional Management of Cancer-Associated Pain.

Moderate to severe pain occurs in many cancer patients during their clinical course and may stem from the primary pathology, metastasis, or as treatment side effects. Uncontrolled pain using conservative medical therapy can often lead to patient distress, loss of productivity, shorter life expectancy, longer hospital stays, and increase in healthcare utilization. Various publications shed light on strategies for conservative medical management for cancer pain and a few international publications have reviewed limited interventional data. Our multi-institutional working group was assembled to review and highlight the body of evidence that exists for opioid utilization for cancer pain, adjunct medication such as ketamine and methadone and interventional therapies. We discuss neurolysis via injections, neuromodulation including targeted drug delivery and spinal cord stimulation, vertebral tumor ablation and augmentation, radiotherapy and surgical techniques. In the United States, there is a significant variance in the interventional treatment of cancer pain based on fellowship training. As a first of its kind, this best practices and interventional guideline will offer evidenced-based recommendations for reducing pain and suffering associated with malignancy.

High-resolution functional profiling of a gammaherpesvirus RTA locus in the context of the viral genome.

Gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus are associated with multiple human cancers. Our goal was to develop a quantitative, high-throughput functional profiling system to identify viral cis-elements and protein subdomains critical for virus replication in the context of the herpesvirus genome. In gamma-2 herpesviruses, the transactivating factor RTA is essential for initiation of lytic gene expression and viral reactivation. We used the RTA locus as a model to develop the functional profiling approach. The mutant murine gammaherpesvirus 68 viral library, containing 15-bp random insertions in the RTA locus, was passaged in murine fibroblast cells for multiple rounds of selection. The effect of each 15-bp insertion was characterized using fluorescent-PCR profiling. We identified 1,229 insertions in the 3,845-bp RTA locus, of which 393, 282, and 554 were critically impaired, attenuated, and tolerated, respectively, for viral growth. The functional profiling phenotypes were verified by examining several individual RTA mutant clones for transactivating function of the RTA promoter and transcomplementing function of the RTA-null virus. Thus, the profiling approach enabled us to identify several novel functional domains in the RTA locus in the context of the herpesvirus genome. Importantly, our study has demonstrated a novel system to conduct high-density functional genetic mapping. The genome-scale expansion of the genetic profiling approach will expedite the functional genomics research on herpesvirus.

How do cotton light interception and carbohydrate partitioning respond to cropping systems including monoculture, intercropping with wheat, and direct-seeding after wheat?

Different cotton (Gossypium hirsutum L.)-wheat (Triticum aestivum) planting patterns are widely applied in the Yellow River Valley of China, and crop yield mainly depends on light interception. However, little information is available on how cotton canopy light capturing and yield distribution are affected by planting patterns. Hence, field experiments were conducted in 2016 and 2017 to study the response of cotton canopy light interception, square and boll distribution, the leaf area index (LAI) and biomass accumulation to three planting patterns: a cotton monoculture (CM, planted on 15 May) system, a cotton/wheat relay intercropping (CWI, planted on 15 May) system, in which three rows of wheat rows were intercropped with one row of cotton, and a system in which cotton was directly seeded after wheat (CWD, planted on 15 June). The following results were obtained: 1) greater light capture capacity was observed for cotton plants in the CM and CWI compared with the CWD, and the light interception of the CM was 22.4% and 51.4% greater than that of the CWI and CWD, respectively, at 30 days after sowing (DAS) in 2016; 2) more bolls occurred at the first sympodial position (SP) than at other SPs for plants in the CM; 3) based on the LAI and biomass accumulation, the cotton growth rate was the greatest in CWD, followed by CM and CWI; and 4) the CM produced significantly greater yields than did the other two treatments because it yielded more bolls and greater boll weight. Information on the characteristics of cotton growth and development in response to different planting patterns would be helpful for understanding the response of cotton yields to planting patterns and would facilitate the improvement of cotton productivity.

Treatment of methyl orange by calcined layered double hydroxides in aqueous solution: adsorption property and kinetic studies.

Adsorption of a weak acid dye, methyl orange (MO) by calcined layered double hydroxides (LDO) with Zn/Al molar ratio of 3:1 was investigated. In the light of so called "memory effect," LDO was found to recover their original layered structure in the presence of appropriate anions, after adsorption part of MO(-) and CO(2-)(3) (come from air) intercalated into the interlayer of LDH which had been supported by XRD and ICP. The results of adsorption experiments indicate that the maximum capacity of MO at equilibrium (Q(e)) and percentage of adsorption (eta%) with a fixed adsorbent dose of 0.5 g L(-1) were found to be 181.9 mg g(-1) and 90.95%, respectively, when MO concentration, temperature, pH and equilibrium time were 100 mg L(-1), 298 K, 6.0 and 120 min, respectively. The isotherms showed that the adsorption of MO by Zn/Al-LDO was both consistent with Langmuir and Freundlich equations. The adsorption process was spontaneous and endothermic in nature and followed pseudo-second-order kinetic model. The calculated value of E(a) was found to be 77.1 kJ mol(-1), which suggests that the process of adsorption of methyl orange is controlled by the rate of reaction rather than diffusion. The possible mechanism for MO adsorption has also been presumed. In addition, the competitive anions on adsorption and the regeneration of Zn/Al-LDO have also been investigated.