Insecure attachment as a predictor of depressive and anxious symptomology.

BACKGROUND: Most studies have shown that insecure attachment and stress are important risk factors in the development of depression and anxiety. However, it is unclear whether distinct patterns of insecure attachment may relate differently to depression and anxiety following stressful events. Thus, the current study examined whether anxious and avoidant attachment, both of which are operationalized as insecure attachment, predict depressive and anxious symptoms following the occurrence of hassles. METHOD: A sample of 662 Chinese university students was recruited from Hunan, China. At the initial assessment, participants completed self-report measures assessing insecure attachment (i.e. anxious and avoidant attachment), hassles, anxious symptoms, and depressive symptoms. Additionally, hassles and symptoms of anxiety and depression were assessed once a month for the subsequent 6 months. RESULTS: The results of hierarchical linear modeling analyses indicated a significant interaction between anxious attachment and hassles in predicting follow-up depressive symptoms. Specifically, participants with high levels of anxious, but not avoidant, attachment reported high levels of depressive symptoms when experiencing high, as opposed to low, levels of hassles. At the same time, while both anxious and avoidant attachment predicted higher levels of anxious symptoms over time, a cross-level, significant interaction did not emerge. CONCLUSIONS: Insecure attachment styles serve as a vulnerability factor in the development of depressive and anxious symptoms in Chinese young adults. Consequently, fostering the development of secure attachment in prevention and intervention programs may, ultimately, prevent the onset and maintenance of depressive and anxious disorders.

Elevated amygdala activity to negative faces in young adults with early onset major depressive disorder.

Abnormalities in amygdala activity have been implicated in adolescents and older adults with major depressive disorder (MDD), but few studies have focused on young adults with early-onset MDD. In this study, we measured amygdala activity in 27 young adults with early-onset MDD and 25 healthy controls (HC) using functional magnetic resonance imaging (fMRI) with an emotional processing task. Both groups showed significant bilateral activation within the amygdala to threat-related facial expressions. In the matching face task, the activations of the left amygdala, thalamus, prefrontal and temporal cortex were significantly greater while the activation of the right prefrontal was significantly lower for the MDD group compared with the HC group. For the MDD group, there was a significant positive correlation between the activity of the amygdala and scores on the Chinese version of the Center for Epidemiologic Studies Depression Scale. Overall, our findings suggest that young adults with early-onset MDD may be characterized by abnormalities in nodes along the fronto-limbic pathways when facing threat-related facial expression.

Gray Matter Abnormalities of Orbitofrontal Cortex and Striatum in Drug-Naïve Adult Patients With Obsessive-Compulsive Disorder.

Objective: This study examined whether obsessive-compulsive disorder (OCD) patients have gray matter abnormalities in regions related to executive function, and whether such abnormalities are associated with impaired executive function. Methods: Multiple scales were administered to 27 first-episode drug-naïve OCD patients and 29 healthy controls. Comprehensive brain morphometric indicators of orbitofrontal cortex (OFC) and three striatum areas (caudate, putamen, and pallidum) were determined. Hemisphere lateralization index was calculated for each region of interest. Correlations between lateralization index and psychological variables were examined in OCD group. Results: The OCD group had greater local gyrification index for the right OFC and greater gray matter volumes of the bilateral putamen and left pallidum than healthy controls. They also had weaker left hemisphere superiority for local gyrification index of the OFC and gray matter volume of the putamen, but stronger left hemisphere superiority for gray matter volume of the pallidum. Patients' lateralization index for local gyrification index of the OFC correlated negatively with Yale-Brown Obsessive Compulsive Scale and Dysexecutive Questionnaire scores, respectively. Conclusion: Structural abnormalities of the bilateral putamen, left pallidum, and right OFC may underlie OCD pathology. Abnormal lateralization in OCD may contribute to the onset of obsessive-compulsive symptoms and impaired executive function.

Do the early attentional components of ERPs reflect attentional bias in depression? It depends on the stimulus presentation time.

OBJECTIVE: The study aimed to utilize behavioral and electrophysiological data to investigate whether depressed patients show an attentional bias in a task that allows for explicit insight into the time course of selective attention processes. METHODS: Event-related potentials (ERPs) were collected from 24 patients with major depressive disorder (MDD) and 25 never-depressed individuals (ND) during a dot-probe task, using pairs of affectively valenced pictures as cues. Cue presentation time was either 100 ms or 500 ms. RESULTS: When the cue presentation time was 500 ms, bias scores for positive-neutral picture pairs (POS-NEU) were negative for the MDD group and positive for the ND group which means ND individuals were able to successfully select positive information. These behavioral effects were supported by ERP results. In the ND group, at the right parietal-occipital region, P1 amplitude during valid POS-NEU pairs was significantly larger than that during invalid POS-NEU pairs; this pattern did not appear in the MDD group. CONCLUSIONS: These results suggest that MDD patients are characterized by a deficit in protection bias, meaning that these participants cannot avoid attending to negative information in their environment, but only when negative stimuli are presented for a sufficient period of time. SIGNIFICANCE: Attentional bias is modulated by duration of emotional pictures presentation in depression.