Detalhe da pesquisa
1.
Design of a novel long-acting dual GLP-1/GIP receptor agonist.
Bioorg Med Chem
; 100: 117630, 2024 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38330849
2.
Long-Term Strategies for Poorly Water-Soluble Peptides: Combining Fatty Acid Modification with PAS Fusion.
Bioconjug Chem
; 34(12): 2366-2374, 2023 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38037956
3.
Design, synthesis and biological evaluation of novel N-(methyl-d3) pyridazine-3-carboxamide derivatives as TYK2 inhibitors.
Bioorg Med Chem Lett
; 86: 129235, 2023 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36907336
4.
Discovery of imidazo[1,2-b]pyridazine macrocyclic derivatives as novel ALK inhibitors capable of combating multiple resistant mutants.
Bioorg Med Chem Lett
; 89: 129309, 2023 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37127101
5.
Design, synthesis, and biological evaluation of a potential long-acting glucagon-like peptide-1 (GLP-1) analog.
Bioorg Med Chem
; 85: 117291, 2023 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37098289
6.
Design and synthesis of boron-containing ALK inhibitor with favorable in vivo efficacy.
Bioorg Med Chem
; 75: 117071, 2022 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-36332597
7.
Discovery of potent and selective Bcl-2 inhibitors with acyl sulfonamide skeleton.
Bioorg Med Chem
; 47: 116350, 2021 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34536651
8.
Design and synthesis of boron-containing diphenylpyrimidines as potent BTK and JAK3 dual inhibitors.
Bioorg Med Chem
; 28(2): 115236, 2020 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31843459
9.
Magnesium isoglycyrrhizinate ameliorates high fructose-induced liver fibrosis in rat by increasing miR-375-3p to suppress JAK2/STAT3 pathway and TGF-ß1/Smad signaling.
Acta Pharmacol Sin
; 40(7): 879-894, 2019 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-30568253
10.
Synthesis and biological evaluation of deuterated sofosbuvir analogs as HCV NS5B inhibitors with enhanced pharmacokinetic properties.
J Labelled Comp Radiopharm
; 62(5): 215-229, 2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30827031
11.
Structure-activity relationship study of a series of caspase inhibitors containing γ-amino acid moiety for treatment of cholestatic liver disease.
Bioorg Med Chem Lett
; 28(10): 1874-1878, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29650287
12.
Author Correction: Magnesium isoglycyrrhizinate ameliorates high fructose-induced liver fibrosis in rat by increasing miR-375-3p to suppress JAK2/STAT3 pathway and TGF-ß1/Smad signaling.
Acta Pharmacol Sin
; 43(6): 1616, 2022 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-34493815
13.
C-Aryl glucoside SGLT2 inhibitors containing a biphenyl motif as potential anti-diabetic agents.
Bioorg Med Chem Lett
; 25(14): 2744-8, 2015 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26026363
14.
Discovery of potent dipeptidyl peptidase IV inhibitors through pharmacophore hybridization and hit-to-lead optimization.
Bioorg Med Chem
; 21(7): 1749-55, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23434133
15.
Discovery, optimization and biological evaluation of novel HBsAg production inhibitors.
Eur J Med Chem
; 256: 115387, 2023 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37187088
16.
A quantitative method for determination of colistin E2 methanesulphonate in human plasma by 15N-labeled colistin E2.
Sci Rep
; 13(1): 18348, 2023 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37884605
17.
Novel TYK2 Inhibitors with an N-(Methyl-d 3)pyridazine-3-carboxamide Skeleton for the Treatment of Autoimmune Diseases.
ACS Med Chem Lett
; 13(11): 1730-1738, 2022 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36385928
18.
Magnesium isoglycyrrhizinate prevents cadmium-induced activation of JNK and apoptotic hepatocyte death by reversing ROS-inactivated PP2A.
J Pharm Pharmacol
; 73(12): 1663-1674, 2021 Dec 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34468764
19.
Synthesis and biological evaluation of esterified and acylated derivatives of NH2-(AEEA)5-amphotericin B.
J Antibiot (Tokyo)
; 74(2): 133-142, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32939075
20.
D- and Unnatural Amino Acid Substituted Antimicrobial Peptides With Improved Proteolytic Resistance and Their Proteolytic Degradation Characteristics.
Front Microbiol
; 11: 563030, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33281761