Detalhe da pesquisa
1.
Pomiferin targets SERCA, mTOR, and P-gp to induce autophagic cell death in apoptosis-resistant cancer cells, and reverses the MDR phenotype in cisplatin-resistant tumors in vivo.
Pharmacol Res
; 191: 106769, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37061145
2.
SERCA and P-glycoprotein inhibition and ATP depletion are necessary for celastrol-induced autophagic cell death and collateral sensitivity in multidrug-resistant tumor cells.
Pharmacol Res
; 153: 104660, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31982489
3.
Advanced research technology for discovery of new effective compounds from Chinese herbal medicine and their molecular targets.
Pharmacol Res
; 111: 546-555, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27450294
4.
Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells.
Int J Mol Sci
; 14(11): 22618-41, 2013 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24248062
5.
Neferine induces autophagy-dependent cell death in apoptosis-resistant cancers via ryanodine receptor and Ca2+-dependent mechanism.
Sci Rep
; 9(1): 20034, 2019 12 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31882989
6.
Ca2+ signalling plays a role in celastrol-mediated suppression of synovial fibroblasts of rheumatoid arthritis patients and experimental arthritis in rats.
Br J Pharmacol
; 176(16): 2922-2944, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31124139
7.
Mode of Action Analyses of Neferine, a Bisbenzylisoquinoline Alkaloid of Lotus (Nelumbo nucifera) against Multidrug-Resistant Tumor Cells.
Front Pharmacol
; 8: 238, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28529482
8.
N-Desmethyldauricine Induces Autophagic Cell Death in Apoptosis-Defective Cells via Ca2+ Mobilization.
Front Pharmacol
; 8: 388, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28670281
9.
Thalidezine, a novel AMPK activator, eliminates apoptosis-resistant cancer cells through energy-mediated autophagic cell death.
Oncotarget
; 8(18): 30077-30091, 2017 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28404910
10.
Hernandezine, a novel AMPK activator induces autophagic cell death in drug-resistant cancers.
Oncotarget
; 7(7): 8090-104, 2016 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-26811496
11.
Autophagic degradation of epidermal growth factor receptor in gefitinib-resistant lung cancer by celastrol.
Int J Oncol
; 49(4): 1576-88, 2016 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-27498688
12.
(Z)3,4,5,4'-trans-tetramethoxystilbene, a new analogue of resveratrol, inhibits gefitinb-resistant non-small cell lung cancer via selectively elevating intracellular calcium level.
Sci Rep
; 5: 16348, 2015 Nov 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26542098
13.
Natural small-molecule enhancers of autophagy induce autophagic cell death in apoptosis-defective cells.
Sci Rep
; 4: 5510, 2014 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24981420