Detalhe da pesquisa
1.
PAD2 dysregulation and aberrant protein citrullination feature prominently in reactive astrogliosis and myelin protein aggregation in sporadic ALS.
Neurobiol Dis
; 192: 106414, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38253209
2.
TDP-43 knockdown in mouse model of ALS leads to dsRNA deposition, gliosis, and neurodegeneration in the spinal cord.
Cereb Cortex
; 33(10): 5808-5816, 2023 05 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36443249
3.
Imaging Net Retrograde Axonal Transport In Vivo: A Physiological Biomarker.
Ann Neurol
; 91(5): 716-729, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35178738
4.
Anti-SOD1 Nanobodies That Stabilize Misfolded SOD1 Proteins Also Promote Neurite Outgrowth in Mutant SOD1 Human Neurons.
Int J Mol Sci
; 23(24)2022 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36555655
5.
Mutant PFN1 causes ALS phenotypes and progressive motor neuron degeneration in mice by a gain of toxicity.
Proc Natl Acad Sci U S A
; 113(41): E6209-E6218, 2016 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27681617
6.
Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis.
Nature
; 488(7412): 499-503, 2012 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-22801503
7.
Systemic AAV9 gene transfer in adult GM1 gangliosidosis mice reduces lysosomal storage in CNS and extends lifespan.
Hum Mol Genet
; 24(15): 4353-64, 2015 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25964428
8.
Creating conditional dual fluorescence labeled transgenic animals for studying function of small noncoding RNAs.
Connect Tissue Res
; 58(1): 103-115, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27763799
9.
Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis.
Proc Natl Acad Sci U S A
; 111(12): E1121-9, 2014 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24616503
10.
Widespread spinal cord transduction by intrathecal injection of rAAV delivers efficacious RNAi therapy for amyotrophic lateral sclerosis.
Hum Mol Genet
; 23(3): 668-81, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24108104
11.
Reactive astrocytes secrete lcn2 to promote neuron death.
Proc Natl Acad Sci U S A
; 110(10): 4069-74, 2013 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-23431168
12.
Global CNS transduction of adult mice by intravenously delivered rAAVrh.8 and rAAVrh.10 and nonhuman primates by rAAVrh.10.
Mol Ther
; 22(7): 1299-1309, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24781136
13.
Several rAAV vectors efficiently cross the blood-brain barrier and transduce neurons and astrocytes in the neonatal mouse central nervous system.
Mol Ther
; 19(8): 1440-8, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21610699
14.
Protein citrullination marks myelin protein aggregation and disease progression in mouse ALS models.
Acta Neuropathol Commun
; 10(1): 135, 2022 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36076282
15.
The enhanced association between mutant CHMP2B and spastin is a novel pathological link between frontotemporal dementia and hereditary spastic paraplegias.
Acta Neuropathol Commun
; 10(1): 169, 2022 11 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36414997
16.
Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in mice.
PLoS One
; 17(2): e0255710, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35113871
17.
Pol II-expressed shRNA knocks down Sod2 gene expression and causes phenotypes of the gene knockout in mice.
PLoS Genet
; 2(1): e10, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16450009
18.
Designing siRNA that distinguish between genes that differ by a single nucleotide.
PLoS Genet
; 2(9): e140, 2006 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-16965178
19.
Direct Intrathecal Injection of Recombinant Adeno-associated Viruses in Adult Mice.
J Vis Exp
; (144)2019 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30829325
20.
A construct with fluorescent indicators for conditional expression of miRNA.
BMC Biotechnol
; 8: 77, 2008 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-18840295