Detalhe da pesquisa
1.
The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells.
Nat Immunol
; 16(9): 950-60, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26214742
2.
Combined immunodeficiency and impaired PI3K signaling in a patient with biallelic LCP2 variants.
J Allergy Clin Immunol
; 152(3): 807-813.e7, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37211057
3.
SLP76 Mutation Associated with Combined Immunodeficiency and EBV-Related Lymphoma.
J Clin Immunol
; 43(3): 625-635, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36474126
4.
Itk Promotes the Integration of TCR and CD28 Costimulation through Its Direct Substrates SLP-76 and Gads.
J Immunol
; 206(10): 2322-2337, 2021 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33931484
5.
Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells.
EMBO J
; 30(15): 3160-72, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21725281
6.
Src homology 2-domain containing leukocyte-specific phosphoprotein of 76 kDa is mandatory for TCR-mediated inside-out signaling, but dispensable for CXCR4-mediated LFA-1 activation, adhesion, and migration of T cells.
J Immunol
; 183(9): 5756-67, 2009 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19812192
7.
Inherited SLP76 deficiency in humans causes severe combined immunodeficiency, neutrophil and platelet defects.
J Exp Med
; 218(3)2021 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33231617
8.
Bridging the Gap: Modulatory Roles of the Grb2-Family Adaptor, Gads, in Cellular and Allergic Immune Responses.
Front Immunol
; 10: 1704, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31402911
9.
Autophosphorylation-dependent degradation of Pak1, triggered by the Rho-family GTPase, Chp.
Biochem J
; 404(3): 487-97, 2007 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17355222
10.
A Pak- and Pix-dependent branch of the SDF-1alpha signalling pathway mediates T cell chemotaxis across restrictive barriers.
Biochem J
; 397(1): 213-22, 2006 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16515536
11.
Dimerization of the adaptor Gads facilitates antigen receptor signaling by promoting the cooperative binding of Gads to the adaptor LAT.
Sci Signal
; 10(498)2017 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28951535
12.
Modulation of TCR responsiveness by the Grb2-family adaptor, Gads.
Cell Signal
; 27(1): 125-34, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25452106
13.
Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation.
J Cell Biol
; 195(5): 839-53, 2011 Nov 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-22105350
14.
SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK.
Proc Natl Acad Sci U S A
; 104(16): 6638-43, 2007 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-17420479
15.
Dual role of SLP-76 in mediating T cell receptor-induced activation of phospholipase C-gamma1.
J Biol Chem
; 282(5): 2937-46, 2007 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-17148460
16.
T cell receptor-induced activation of phospholipase C-gamma1 depends on a sequence-independent function of the P-I region of SLP-76.
J Biol Chem
; 280(9): 8364-70, 2005 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-15623534
17.
Linker for activation of T cells, zeta-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization.
J Immunol
; 171(2): 860-6, 2003 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12847255