Detalhe da pesquisa
1.
Mechanistic insights into tris(2-chloroisopropyl) phosphate biomineralization coupled with lead (II) biostabilization driven by denitrifying bacteria.
Sci Total Environ
; 945: 173927, 2024 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38901584
2.
Total syntheses of bryostatins: synthesis of two ring-expanded bryostatin analogues and the development of a new-generation strategy to access the C7-C27 fragment.
Chemistry
; 17(35): 9789-805, 2011 Aug 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-21780195
3.
Atom-economic and stereoselective syntheses of the ring a and B subunits of the bryostatins.
Chemistry
; 17(35): 9777-88, 2011 Aug 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-21774000
4.
Total synthesis of bryostatins: the development of methodology for the atom-economic and stereoselective synthesis of the ring C subunit.
Chemistry
; 17(35): 9762-76, 2011 Aug 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-21793057
5.
Cyclic amide bioisosterism: strategic application to the design and synthesis of HCV NS5B polymerase inhibitors.
Bioorg Med Chem Lett
; 20(15): 4614-9, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20584604
6.
Discovery of a potent, selective and orally bioavailable 3,9-diazaspiro[5.5]undeca-2-one CCR5 antagonist.
Bioorg Med Chem Lett
; 19(1): 209-13, 2009 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19014885
7.
3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma.
J Med Chem
; 62(15): 6876-6893, 2019 08 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31282155
8.
Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate ( S)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1 H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385).
J Med Chem
; 61(21): 9691-9721, 2018 11 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30289716
9.
A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma.
Cancer Res
; 76(18): 5491-500, 2016 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27635045
10.
A Ru-catalyzed tandem alkyne-enone coupling/Michael addition: synthesis of 4-methylene-2,6-cis-tetrahydropyrans.
Org Lett
; 7(21): 4761-4, 2005 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-16209529
11.
Imidazopyridine-Based Fatty Acid Synthase Inhibitors That Show Anti-HCV Activity and in Vivo Target Modulation.
ACS Med Chem Lett
; 4(1): 113-7, 2013 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900571
12.
Novel CCR5 antagonists for the treatment of HIV infection: a review of compounds patented in 2006 - 2008.
Expert Opin Ther Pat
; 20(3): 325-54, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20180619
13.
Discovery of bioavailable 4,4-disubstituted piperidines as potent ligands of the chemokine receptor 5 and inhibitors of the human immunodeficiency virus-1.
J Med Chem
; 51(20): 6538-46, 2008 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-18811134
14.
Surface-rolling molecules.
J Am Chem Soc
; 128(14): 4854-64, 2006 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-16594722
15.
A formal synthesis of (-)-mycalamide A.
J Am Chem Soc
; 126(1): 48-9, 2004 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-14709053
16.
Recent progress in discovery of small-molecule CCR5 chemokine receptor ligands as HIV-1 inhibitors.
Bioorg Med Chem
; 11(13): 2663-76, 2003 Jul 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-12788340
17.
Novel prodrug approach to amprenavir-based HIV-1 protease inhibitors via O-->N acyloxy migration of P1 moiety.
Bioorg Med Chem Lett
; 13(15): 2523-6, 2003 Aug 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-12852957
18.
Synthesis of a ring-expanded bryostatin analogue.
J Am Chem Soc
; 129(8): 2206-7, 2007 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17279751